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Showing 1–3 of 3 results
Advanced filters: Author: Corella S Casas-Delucchi Clear advanced filters

  • How one copy of the X chromosome is silenced in replicating female somatic cells is poorly understood. Here, the authors demonstrate that the inactive X chromosome is replicated before constitutive heterochromatin and that histone hypoacetylation has a role in controlling replication of the inactive X chromosome.

    • Corella S. Casas-Delucchi
    • Alessandro Brero
    • M. Cristina Cardoso
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-11

  • DNA replication of repetitive sequences was recreated in a test tube using purified components. DNA alone was sufficient to induce stalling. Both stalling and recovery were dictated by the capacity of DNA to fold into unusual secondary structures.

    • Corella S. Casas-Delucchi
    • Manuel Daza-Martin
    • Gideon Coster
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-20

  • GFP fluorescence can be modulated in mammalian cells by binding to single-chain antibodies (nanobodies), selected to make GFP brighter or dimmer; these changes are explained by the crystal structures of the GFP-nanobody complexes. The applications of such nanobodies to monitor protein expression and subcellular localization in real time are explored.

    • Axel Kirchhofer
    • Jonas Helma
    • Ulrich Rothbauer
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 133-138