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Showing 1–14 of 14 results
Advanced filters: Author: Corey Archer Clear advanced filters

  • Observations of natural samples combined with laboratory experiments reveal that manganese minerals substantially influence nickel cycling in marine sediments and seawater, driven by adsorption and incorporation processes.

    • Lena Chen
    • Autum R. Downey
    • Caroline L. Peacock
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Lipid droplet biogenesis is orchestrated by the conserved membrane protein Seipin via an unknown mechanism. Here, the authors use structural, biochemical and molecular dynamics simulation approaches to reveal the mechanism of lipid droplet formation by the yeast Seipin Sei1 and its partner Ldb16.

    • Yoel A. Klug
    • Justin C. Deme
    • Pedro Carvalho
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • KdpFABC is a high-affinity bacterial K+ pump which combines the ion channel-like KdpA and the P-type ATPase KdpB. Here, the authors elucidate the mechanisms underlying transport and the coupling to ATP hydrolysis, and provide evidence that ions are transported via an intersubunit tunnel through KdpA and KdpB.

    • Jakob M. Silberberg
    • Robin A. Corey
    • Inga Hänelt
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Developing molecules that emulate the properties of naturally occurring ice-binding proteins (IBPs) is a daunting challenge. Here, the authors demonstrate the use of phage display for the identification of short peptide mimics of IBPs, which resulted in the identification of a cyclic ice-binding peptide containing just 14 amino acids.

    • Corey A. Stevens
    • Fabienne Bachtiger
    • Harm-Anton Klok
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-8

  • Bacterial O antigen polysaccharides play a role in innate immune response evasion. Here, the authors uncover the ATP-bound structure of the Aquifex aeolicus WzmWzt O antigen ABC transporter, shedding light onto the mechanism of lipid-linked polysaccharide translocation.

    • Christopher A. Caffalette
    • Robin A. Corey
    • Jochen Zimmer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • The Cambrian explosion of biological diversity has been associated with widespread ocean oxygenation, yet early Cambrian ocean redox conditions remain controversial. Here, the authors present a suite of molybdenum isotope data and show that the ocean was oxygenated to modern-like levels by 521 Ma.

    • Xi Chen
    • Hong-Fei Ling
    • Corey Archer
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-7

  • Native mass spectrometry, HDX-MS and MD simulations define the mechanism for how LPS binding to the Gram-negative outer membrane complex LptDE opens the LptD lateral exit gate and how thanatin impairs transport across the periplasm.

    • Francesco Fiorentino
    • Joshua B. Sauer
    • Carol V. Robinson
    Research
    Nature Chemical Biology
    Volume: 17, P: 187-195

  • TMEM16K is a member of the TMEM16 family of integral membrane proteins that are either lipid scramblases or chloride channels. Here the authors combine cell biology, electrophysiology measurements, X-ray crystallography, cryo-EM and MD simulations to structurally characterize TMEM16K and show that it is an ER-resident lipid scramblase.

    • Simon R. Bushell
    • Ashley C. W. Pike
    • Elisabeth P. Carpenter
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • In eukaryotes the SLC35 family of solute carriers mediate the selective uptake of nucleotide sugars from the cytoplasm into the Endoplasmic Reticulum or Golgi. Here authors report the crystal structure of the yeast GDP-mannose transporter, Vrg4, bound to guanine monophosphate (GMP) revealing the molecular basis for GMP recognition and transport.

    • Joanne L. Parker
    • Robin A. Corey
    • Simon Newstead
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • KUP transporters facilitate potassium uptake by the co-transport of protons and are key players in potassium homeostasis. Here authors identify the potassium importer KimA from Bacillus subtilis as a new member of the KUP transporter family and show the cryo-EM structure of KimA in an inward-occluded, trans-inhibited conformation.

    • Igor Tascón
    • Joana S. Sousa
    • Inga Hänelt
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Protein-lipid interactions can mediate the function of membrane proteins. Here coarse-grained molecular dynamics free energy perturbation simulations yield binding free energies for phosphoinositide lipids to hKir channels and mutants, in agreement with electrophysiological measurements.

    • Tanadet Pipatpolkai
    • Robin A. Corey
    • Phillip J. Stansfeld
    ResearchOpen Access
    Communications Chemistry
    Volume: 3, P: 1-10