The genetic characterisation of mixed phenotype acute leukemia (MPAL) remains limited. Here, single cell multi-omics analysis of 14 adult MPAL patients identifies a stem cell-like transcriptomic signature expressed by MPAL blasts that is indicative of high differentiation potential and gives rise to a gene set score MPAL95 that is predictive of survival.
- Cheryl A. C. Peretz
- Vanessa E. Kennedy
- Catherine C. Smith