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Author Correction: Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action

Rachel L. Palte
Veronica Juan
Giovanna Scapin
Amendments and CorrectionsOpen Access15 Nov 2021
Communications Biology

Volume: 4, P: 1-2
Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy

Targeted IKZF2 degradation represents a potential therapeutic strategy for cancer immunotherapy. Here, the authors described the discovery of PVTX-405 as a potent, highly selective, and orally efficacious IKZF2 molecular glue degrader and their preclinical data support the clinical development of PVTX-405.

Zhixiang Chen
Harshil Dhruv
Shaomeng Wang
ResearchOpen Access01 May 2025
Nature Communications

Volume: 16, P: 1-16
Structures of active-state orexin receptor 2 rationalize peptide and small-molecule agonist recognition and receptor activation

Agonists of the orexin receptor 2 (OX₂R) show promise in the treatment of narcolepsy. Cryo-EM structures of active-state OX₂R bound to an endogenous peptide agonist and a small-molecule agonist suggest a molecular mechanism that rationalizes both receptor activation and inhibition.

Chuan Hong
Noel J. Byrne
Kaspar Hollenstein
ResearchOpen Access05 Feb 2021
Nature Communications

Volume: 12, P: 1-11
Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

IgG4 antibodies can exchange Fab arms and show different affinities for Fc receptors than do other IgG subclasses. The structure of full-length pembrolizumab, a human IgG4 approved to treat advanced melanoma, provides a framework to understand IgG4's properties.

Giovanna Scapin
Xiaoyu Yang
Corey Strickland
Research23 Nov 2015
Nature Structural & Molecular Biology

Volume: 22, P: 953-958
Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action

Palte et al provide cryo-EM structures of five potent and inhibitory monoclonal antibodies bound to human Arginase 1, a T-cell modulating metalloenzyme and a cancer drug target. They provide structural insights that will aid in the evaluation of these antibodies as therapeutic inhibitors of arginasemediated T-cell suppression.

Rachel L. Palte
Veronica Juan
Giovanna Scapin
ResearchOpen Access29 Jul 2021
Communications Biology

Volume: 4, P: 1-13
Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma

Whole-exome sequencing of human brain metastases from lung adenocarcinoma uncovers new drivers by comparison of somatic alteration frequencies in brain metastasis cases to those in primary lung adenocarcinomas.

David J. H. Shih
Naema Nayyar
Priscilla K. Brastianos
Research23 Mar 2020
Nature Genetics

Volume: 52, P: 371-377
Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

Cryo-electron microscopy structures of insulin in a complex with the insulin receptor define the S2 binding site on the receptor and suggest a mechanism for downstream propagation of insulin signalling.

Giovanna Scapin
Venkata P. Dandey
Bridget Carragher
Research28 Feb 2018
Nature

Volume: 556, P: 122-125
Pembrolizumab microgravity crystallization experimentation

Paul Reichert
Winifred Prosise
Corey Strickland
ResearchOpen Access02 Dec 2019
npj Microgravity

Volume: 5, P: 1-8

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