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Showing 1–2 of 2 results
Advanced filters: Author: Corey Winston Jones-Weinert Clear advanced filters

  • Hutchinson–Gilford progeria syndrome causes premature aging. Here the authors show that activation of the DNA damage response at dysfunctional telomeres and transcription of telomeric non-coding RNAs contributes to the pathogenesis, which can be ameliorated by treatment with sequence-specific telomeric antisense oligonucleotides.

    • Julio Aguado
    • Agustin Sola-Carvajal
    • Fabrizio d’Adda di Fagagna
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Long non-coding RNAs transcribed at DNA damaged sites can play part in DNA damage response. Here the authors reveal that damaged induced lncRNAs can form DNA:RNA hybrids at resected DNA-ends. These hybrids are involved in recruiting HR-mediated repair machinery which, in turn, controls their level at DSBs.

    • Giuseppina D’Alessandro
    • Donna Rose Whelan
    • Fabrizio d’Adda di Fagagna
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17