Nature Search

A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome

Metabolic syndrome is characterized by complex phenotypes that increases the risk of cardiovascular disease and type 2 diabetes. Here the authors’ integrative network analysis suggests BTK inhibitor ibrutinib to be a promising treatment through its obesity-associated inflammation lowering effect.

Karla Misselbeck
Silvia Parolo
Corrado Priami
ResearchOpen Access18 Nov 2019
Nature Communications

Volume: 10, P: 1-14
Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells

Cells respond to increasing concentrations of EGF by altering the balance between EGFR phosphorylation and ubiquitination. Here the authors show that the establishment of an EGFR signaling threshold requires both a multiplicity of binding sites and cooperative binding of Cbl and Grb2 to the EGFR.

Fabrizio Capuani
Alexia Conte
Andrea Ciliberto
ResearchOpen Access12 Aug 2015
Nature Communications

Volume: 6, P: 1-14
A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis

Karla Misselbeck
Luca Marchetti
Patrick J. Stover
ResearchOpen Access11 Apr 2017
Scientific Reports

Volume: 7, P: 1-11
Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules

Isar Nassiri
Rosario Lombardo
Corrado Priami
ResearchOpen Access07 Jul 2016
Scientific Reports

Volume: 6, P: 1-19
Regulatory Crosstalk of Doxorubicin, Estradiol and TNFα Combined Treatment in Breast Cancer-derived Cell Lines

Isar Nassiri
Alberto Inga
Corrado Priami
ResearchOpen Access23 Oct 2019
Scientific Reports

Volume: 9, P: 1-11
Novel drug target identification for the treatment of dementia using multi-relational association mining

Thanh-Phuong Nguyen
Corrado Priami
Laura Caberlotto
ResearchOpen Access08 Jul 2015
Scientific Reports

Volume: 5, P: 1-13
Mechanistic interplay between ceramide and insulin resistance

Federico Reali
Melissa J. Morine
Corrado Priami
ResearchOpen Access23 Jan 2017
Scientific Reports

Volume: 7, P: 1-9
Early outcome detection for COVID-19 patients

Alina Sîrbu
Greta Barbieri
Corrado Priami
ResearchOpen Access16 Sept 2021
Scientific Reports

Volume: 11, P: 1-14
QSPcc reduces bottlenecks in computational model simulations

Lombardo and colleagues present QSPcc, a computational code compiler designed to convert code from popular scientific programming languages, such as MATLAB or R, into fast-running C code. This reduces the computational load required for complex modelling approaches and reduces user investment learning additional complex languages.

Danilo Tomasoni
Alessio Paris
Rosario Lombardo
ResearchOpen Access01 Sept 2021
Communications Biology

Volume: 4, P: 1-10
Consensus Clustering of temporal profiles for the identification of metabolic markers of pre-diabetes in childhood (EarlyBird 73)

Mario Lauria
Maria Persico
François-Pierre Martin
ResearchOpen Access23 Jan 2018
Scientific Reports

Volume: 8, P: 1-16
The 5-formyltetrahydrofolate futile cycle reduces pathway stochasticity in an extended hybrid-stochastic model of folate-mediated one-carbon metabolism

Karla Misselbeck
Luca Marchetti
Martha S. Field
ResearchOpen Access13 Mar 2019
Scientific Reports

Volume: 9, P: 1-10
A computationally driven analysis of the polyphenol-protein interactome

Sébastien Lacroix
Jasna Klicic Badoux
Sofia Moco
ResearchOpen Access02 Feb 2018
Scientific Reports

Volume: 8, P: 1-13
Cross-disease analysis of Alzheimer’s disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases

Laura Caberlotto
T.-Phuong Nguyen
Lucia Carboni
ResearchOpen Access08 Mar 2019
Scientific Reports

Volume: 9, P: 1-13
A Novel Insulin/Glucose Model after a Mixed-Meal Test in Patients with Type 1 Diabetes on Insulin Pump Therapy

Luca Marchetti
Federico Reali
Corrado Priami
ResearchOpen Access08 Nov 2016
Scientific Reports

Volume: 6, P: 1-9
A network analysis of cofactor-protein interactions for analyzing associations between human nutrition and diseases

Marie Pier Scott-Boyer
Sébastien Lacroix
Corrado Priami
ResearchOpen Access18 Jan 2016
Scientific Reports

Volume: 6, P: 1-11
Diversity of key players in the microbial ecosystems of the human body

Ferenc Jordán
Mario Lauria
Corrado Priami
ResearchOpen Access30 Oct 2015
Scientific Reports

Volume: 5, P: 1-10
Context-dependent prediction of protein complexes by SiComPre

Simone Rizzetto
Petros Moyseos
Attila Csikász-Nagy
Special FeaturesOpen Access17 Sept 2018
npj Systems Biology and Applications

Volume: 4, P: 1-9

Search

A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome

Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells

A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis

Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules

Regulatory Crosstalk of Doxorubicin, Estradiol and TNFα Combined Treatment in Breast Cancer-derived Cell Lines

Novel drug target identification for the treatment of dementia using multi-relational association mining

Mechanistic interplay between ceramide and insulin resistance

Early outcome detection for COVID-19 patients

QSPcc reduces bottlenecks in computational model simulations

Consensus Clustering of temporal profiles for the identification of metabolic markers of pre-diabetes in childhood (EarlyBird 73)

The 5-formyltetrahydrofolate futile cycle reduces pathway stochasticity in an extended hybrid-stochastic model of folate-mediated one-carbon metabolism

A computationally driven analysis of the polyphenol-protein interactome

Cross-disease analysis of Alzheimer’s disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases

A Novel Insulin/Glucose Model after a Mixed-Meal Test in Patients with Type 1 Diabetes on Insulin Pump Therapy

A network analysis of cofactor-protein interactions for analyzing associations between human nutrition and diseases

Diversity of key players in the microbial ecosystems of the human body

Context-dependent prediction of protein complexes by SiComPre

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