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Showing 1–6 of 6 results
Advanced filters: Author: Corrie Painter Clear advanced filters

    • DAVID MURRAY
    Research
    Nature
    Volume: 24, P: 459

  • HLA-DM interacts with MHCII and promotes peptide exchange. This activity of HLA-DM is regulated by HLA-DO. The crystal structure of the HLA-DO–HLA-DM complex along with mutagenesis and kinetic analyses reveal that HLA-DO adopts a classical MHCII structure and competitively inhibits HLA-DM's activity on MHCII.

    • Abigail I Guce
    • Sarah E Mortimer
    • Lawrence J Stern
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 90-98

  • Crowdsourcing efforts are currently underway to collect and analyze data from patients with cancer who are affected by the COVID-19 pandemic. These community-led initiatives will fill key knowledge gaps to tackle crucial clinical questions on the complexities of infection with the causative coronavirus SARS-Cov-2 in the large, heterogeneous group of vulnerable patients with cancer.

    • Aakash Desai
    • Jeremy Warner
    • Gilberto Lopes
    Comments & Opinion
    Nature Cancer
    Volume: 1, P: 473-476