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Showing 1–4 of 4 results
Advanced filters: Author: Cory D Rillahan Clear advanced filters

  • Fluorinated, cell-permeable analogs of sialic acid and fucose are processed by monosaccharide salvage pathways to generate sialyl- and fucosyltransferase inhibitors intracellularly. These compounds serve as important new tools to dissect the role of glycan modifications within complex biological systems.

    • Cory D Rillahan
    • Aristotelis Antonopoulos
    • James C Paulson
    Research
    Nature Chemical Biology
    Volume: 8, P: 661-668

  • Scott Lowe and colleagues investigate regulation of Ras signaling during leukemogenesis and show that negative regulators Spry4 and Nf1 prevent transformation to aggressive acute myeloid leukemia in mice.

    • Zhen Zhao
    • Chi-Chao Chen
    • Scott W Lowe
    Research
    Nature Genetics
    Volume: 47, P: 539-543