UNC-89, a giant protein localized to muscle sarcomeres, contains 2 protein kinase domains, one of which, PK2 is a canonical kinase. A missense mutation expected to inactivate PK2 results in worms with an unexpected phenotype suggesting signaling from sarcomeres to mitochondria.
- Yohei Matsunaga
- Hiroshi Qadota
- Guy M. Benian
