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Showing 1–4 of 4 results
Advanced filters: Author: Coyin Oh Clear advanced filters

  • Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomics and chemical screens identified CDK4 and XPO1 as potential therapeutic targets in this cancer.

    • Andrew L. Hong
    • Yuen-Yi Tseng
    • Jesse S. Boehm
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • The original Cancer Cell Line Encyclopedia (CCLE) is expanded with deeper characterization of over 1,000 cell lines, including genomic, transcriptomic, and proteomic data, and integration with drug-sensitivity and gene-dependency data.

    • Mahmoud Ghandi
    • Franklin W. Huang
    • William R. Sellers
    Research
    Nature
    Volume: 569, P: 503-508

  • Identifying the mutational landscape of tumours from cell-free DNA in the blood could help diagnostics in cancer. Here, the authors present ichorCNA, software that quantifies tumour content in cell free DNA, and they demonstrate that cell-free DNA whole-exome sequencing is concordant with metastatic tumour whole-exome sequencing.

    • Viktor A. Adalsteinsson
    • Gavin Ha
    • Matthew Meyerson
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • This large-scale analysis of copy number alterations (CNAs) in patient-derived xenografts (PDXs) across 24 cancer types shows that new CNAs accumulate quickly and that the specific CNAs acquired during passaging differ from those acquired during tumor evolution in patients, suggesting that PDX tumors are under distinct selection pressures from tumors in human hosts.

    • Uri Ben-David
    • Gavin Ha
    • Todd R Golub
    Research
    Nature Genetics
    Volume: 49, P: 1567-1575