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Showing 1–4 of 4 results
Advanced filters: Author: Craig Dobbins Clear advanced filters

  • This study reports the computational design of miniprotein binders of the pattern recognition receptor TLR3. When oligomerized, the miniprotein binders induce TLR3 signaling in cells, suggesting they may be useful components of vaccines or treatments for infectious disease or cancer.

    • Chloe S. Adams
    • Hyojin Kim
    • Neil P. King
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-11

  • Computationally designed genetically encoded proteins can be used to target surface proteins, thereby triggering endocytosis and subsequent intracellular degradation, activating signalling or increasing cellular uptake in specific tissues.

    • Buwei Huang
    • Mohamad Abedi
    • David Baker
    ResearchOpen Access
    Nature
    Volume: 638, P: 796-804

  • Designed novel protein nanoparticle technology integrates antibody targeting and responds to changes in environmental conditions to release protected molecular cargoes, opening new applications for precision medicine.

    • Erin C. Yang
    • Robby Divine
    • David Baker
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1404-1412

  • Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

    • Malcolm G Dunlop
    • Sara E Dobbins
    • Richard S Houlston
    Research
    Nature Genetics
    Volume: 44, P: 770-776