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Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

Experimental deletion of the furin cleavage site of the SARS-CoV-2 spike protein highlights an important role for this site in infection and the need to consider this site when evaluating the neutralization activities of antibodies.

Bryan A. Johnson
Xuping Xie
Vineet D. Menachery
Research25 Jan 2021
Nature

Volume: 591, P: 293-299
The N501Y spike substitution enhances SARS-CoV-2 infection and transmission

Experiments in a hamster model of COVID-19 and human airway epithelial cells show that the spike N501Y mutation is the major determinant of increased fitness of the B.1.1.7 Alpha variant of SARS-CoV-2.

Yang Liu
Jianying Liu
Scott C. Weaver
Research24 Nov 2021
Nature

Volume: 602, P: 294-299
Baseline mapping of Oropouche virology, epidemiology, therapeutics, and vaccine research and development

Megan A. Files
Clairissa A. Hansen
Gregg N. Milligan
ReviewsOpen Access17 Mar 2022
npj Vaccines

Volume: 7, P: 1-10