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Advanced filters: Author: Cuihan Zhou Clear advanced filters

  • The preparation of 14C-labelled compounds is a crucial step in pharmaceutical development but typically requires using toxic, radioactive gases. Now a broadly applicable functional group metathesis reaction has been developed that forms 14C-labelled carboxylic acids in one pot, without added gases, via dynamic exchange with an easily handled carboxylic acid 14C source.

    • R. Garrison Kinney
    • José Zgheib
    • Bruce A. Arndtsen
    Research
    Nature Chemistry
    Volume: 16, P: 556-563