Nature Search

Dysregulated mast cell activation induced by diabetic milieu exacerbates the progression of diabetic peripheral neuropathy in mice

Diabetic peripheral neuropathy (DPN) is associated with immunometabolic stress, but the underlying molecular mechanisms remain unclear. Here the authors use single-cell atlas of human peripheral nerve and data from diabetic mouse models to implicate altered GLUT3, ERK and mTOR signaling and downstream dysregulated mast cell activation in DPN progression.

Xiangyun Yao
Xin Wang
Yun Qian
ResearchOpen Access05 May 2025
Nature Communications

Volume: 16, P: 1-17
Multilayered spraying and gradient dotting of nanodiamond–polycaprolactone guidance channels for restoration of immune homeostasis

Schematic introduction of nanodiamond/polycaprolactone nerve bridge manufacturing process and in vivo performance. The nanodiamond incorporated into concentrical triple-layered structure provided appropriate elasticity and receptivity. In addition, this scaffold regenerated peripheral nerves and induced macrophage polarization in vivo.

Yun Qian
Yuan Cheng
Cunyi Fan
ResearchOpen Access19 Jul 2019
NPG Asia Materials

Volume: 11, P: 1-24
Multilevel neurium-mimetic individualized graft via additive manufacturing for efficient tissue repair

Nerve grafts often fail to match the expected shape and size for branched nerve repair. Here, the authors fabricate a sugar painting-inspired individualized multilevel epi-/peri-/endoneurium-mimetic device to achieve efficient regeneration of neural fibers.

Lingchi Kong
Xin Gao
Cunyi Fan
ResearchOpen Access31 Jul 2024
Nature Communications

Volume: 15, P: 1-17
Genetic analysis and molecular mapping of QTLs for resistance to rice black-streaked dwarf disease in rice

Tong Zhou
Linlin Du
Yijun Zhou
ResearchOpen Access22 Jul 2015
Scientific Reports

Volume: 5, P: 1-8
Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice

Heterotopic ossification (HO) is a painful disease of unknown etiology characterized by extraskeletal bone formation after injury. Here the authors show that TGF-β is increased in HO lesions, where it promotes the early stages of HO pathology, and demonstrate that TGF-β inhibition ameliorates HO in mice.

Xiao Wang
Fengfeng Li
Xu Cao
ResearchOpen Access07 Feb 2018
Nature Communications

Volume: 9, P: 1-13
Inhibition of connexin 43 prevents trauma-induced heterotopic ossification

Bing Tu
Shen Liu
Cunyi Fan
ResearchOpen Access16 Nov 2016
Scientific Reports

Volume: 6, P: 1-12
Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds

Yun Qian
Xu Wang
Cunyi Fan
ResearchOpen Access02 Jun 2021
npj Regenerative Medicine

Volume: 6, P: 1-8
MiR-630 Inhibits Endothelial-Mesenchymal Transition by Targeting Slug in Traumatic Heterotopic Ossification

Yangbai Sun
Jiangyu Cai
Cunyi Fan
ResearchOpen Access04 Mar 2016
Scientific Reports

Volume: 6, P: 1-12
miR-203 inhibits the traumatic heterotopic ossification by targeting Runx2

Bing Tu
Shen Liu
Cunyi Fan
ResearchOpen Access27 Oct 2016
Cell Death & Disease

Volume: 7, P: e2436
RelA/p65 inhibition prevents tendon adhesion by modulating inflammation, cell proliferation, and apoptosis

Shuai Chen
Shichao Jiang
Cunyi Fan
ResearchOpen Access30 Mar 2017
Cell Death & Disease

Volume: 8, P: e2710

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