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Showing 1–6 of 6 results
Advanced filters: Author: Curtis L. Yeager Clear advanced filters

  • It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk

    • Mitchell J. Machiela
    • Weiyin Zhou
    • Stephen J. Chanock
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such events increases with age and is associated with elevated risk of developing subsequent hematological cancers.

    • Kevin B Jacobs
    • Meredith Yeager
    • Stephen J Chanock
    Research
    Nature Genetics
    Volume: 44, P: 651-658

  • Over one hundred loci have been identified to be associated with the familial risk of prostate cancer but the functional effects are poorly understood. Here the authors use single-nucleotide variant and epigentic data to show an underlying genetic architecture marked by histone modification.

    • Alexander Gusev
    • Huwenbo Shi
    • Bogdan Pasaniuc
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Prostate cancer often does not progress to invasive disease and thus markers predicting the course of the disease progression are critical for optimal treatment choices. Here the authors show that variants at two genetic loci correlate with the aggressiveness of prostate cancer.

    • Sonja I. Berndt
    • Zhaoming Wang
    • Stephen J. Chanock
    Research
    Nature Communications
    Volume: 6, P: 1-7

  • Rosalind Eeles, Christopher Haiman and colleagues report genome-wide association and meta-analyses of prostate cancer in populations of European, African, Japanese and Latino ancestry. They identify 23 new susceptibility loci, including one associated with early-onset prostate cancer.

    • Ali Amin Al Olama
    • Zsofia Kote-Jarai
    • Christopher A Haiman
    Research
    Nature Genetics
    Volume: 46, P: 1103-1109