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Advanced filters: Author: Cynthia Rominger Clear advanced filters

  • Gain of function mutations in isocitrate dehydrogenase 1 (IDH1) have been detected in cases of acute myeloid leukemia (AML). The application of an allosteric IDH1 inhibitor in AML cells promotes blast differentiation and restores DNA cytosine methylation patterns.

    • Ujunwa C Okoye-Okafor
    • Boris Bartholdy
    • Ulrich Steidl
    Research
    Nature Chemical Biology
    Volume: 11, P: 878-886