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Modeling the impact of vaccine campaigns on the epidemic transmission dynamics of chikungunya virus outbreaks

A combination of seroprevalence analyses and modeling indicates that the availability of an infection-blocking CHIKV vaccine would have prevented 88% of cases during an outbreak.

Pastor E. Pérez-Estigarribia
Gabriel Ribeiro dos Santos
Henrik Salje
ResearchOpen Access01 May 2025
Nature Medicine

Volume: 31, P: 2335-2341
Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters

Examples of effective live attenuated viral vaccines include the measles, mumps and rubella vaccine, as well as the chickenpox vaccine. In this work, the authors engineer a live attenuated SARS-CoV-2 virus that demonstrates attenuation in numerous in vivo models, and protection in hamsters upon challenge.

Shufeng Liu
Charles B. Stauft
Tony T. Wang
ResearchOpen Access10 Nov 2022
Nature Communications

Volume: 13, P: 1-15
Intranasal or airborne transmission-mediated delivery of an attenuated SARS-CoV-2 protects Syrian hamsters against new variants

Mucosal immune response is important to determine protective efficiency of intranasal vaccines. Here, the authors analyse mucosal immunogenicity, transmissibility, efficacy, and boosting effects of an attenuated SARS-CoV-2 vaccine platform in Syrian hamsters and mice.

Charles B. Stauft
Prabhuanand Selvaraj
Tony T. Wang
ResearchOpen Access09 Jun 2023
Nature Communications

Volume: 14, P: 1-17
Molecular hybridization strategy for tuning bioactive peptide function

A hybrid antimicrobial peptide (AMP) design derived from scorpion venom and parts of other naturally occurring AMPs leads to AMPs with increased antimicrobial activity and minimal toxicity in a mouse infection model and red blood cells.

Cibele Nicolaski Pedron
Marcelo Der Torossian Torres
Vani Xavier Oliveira Junior
ResearchOpen Access19 Oct 2023
Communications Biology

Volume: 6, P: 1-13
MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge

Clement A. Meseda
Charles B. Stauft
Jerry P. Weir
ResearchOpen Access03 Dec 2021
npj Vaccines

Volume: 6, P: 1-10

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Modeling the impact of vaccine campaigns on the epidemic transmission dynamics of chikungunya virus outbreaks

Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters

Intranasal or airborne transmission-mediated delivery of an attenuated SARS-CoV-2 protects Syrian hamsters against new variants

Molecular hybridization strategy for tuning bioactive peptide function

MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge

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