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Showing 1–4 of 4 results

Advanced filters: Author: Cyril Goudet Clear advanced filters

Conformational diversity in class C GPCR positive allosteric modulation

Allosteric control of metabotropic glutamate receptor is of therapeutic value in the treatment of neurological disorders. Here, using cryoEM, the authors describe the diversity of positive allosteric modulation on the metabotropic glutamate receptor, mGlu₅.

Giuseppe Cannone
Ludovic Berto
Guillaume Lebon
ResearchOpen Access13 Jan 2025
Nature Communications

Volume: 16, P: 1-17
Direct observation of lithium polysulfides in lithium–sulfur batteries using operando X-ray diffraction

The presence of polysulfides in Li–S batteries is highly relevant to the battery performance, but their formation and evolution during battery operation are not well understood. Here the authors design an operando X-ray diffraction experiment to reveal their reaction mechanisms.

Joanna Conder
Renaud Bouchet
Claire Villevieille
Research08 May 2017
Nature Energy

Volume: 2, P: 1-7
An allosteric modulator to control endogenous G protein-coupled receptors with light

Alloswitch-1 is a photoswitchable modulator for mGlu5, and it is the first photoswitchable allosteric GPCR modulator. It was generated by adding the azobenzene Ar-N=N-Ar scaffold into an existing positive allosteric modulator of the receptor.

Silvia Pittolo
Xavier Gómez-Santacana
Pau Gorostiza
Research31 Aug 2014
Nature Chemical Biology

Volume: 10, P: 813-815
Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4

C Zussy
X Gómez-Santacana
C Goudet
Research20 Dec 2016
Molecular Psychiatry

Volume: 23, P: 509-520