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Showing 1–3 of 3 results
Advanced filters: Author: Cyril Ribeyre Clear advanced filters

  • Here the authors demonstrate that the dsDNA binding function at the N-terminus of BRCA2 prevents nucleotide depletion-dependent replicative ssDNA gaps but not those induced by PARP inhibition. This function is impaired in breast-cancer variants affecting this region.

    • Domagoj Vugic
    • Isaac Dumoulin
    • Aura Carreira
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19

  • How yeast telomeres avoid triggering DNA damage checkpoints is studied by creating de novo telomere ends with different amounts of telomeric repeats. Rif1 and Rif2 protect short telomere tracts through different mechanisms and by blocking the accumulation of proteins that can activate checkpoint kinase Mec1. Moreover, long telomere tracts can perturb DNA end processing on neighboring short tracts and hence dampen checkpoint activation.

    • Cyril Ribeyre
    • David Shore
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 307-313

  • Telomere protein RAP1 is found in organisms from yeast to mammals, but has different functions. Now the crystal structures of the RAP1 C-terminus (RCT) with its different interacting partners, together with functional analyses, reveal a conserved interaction module used by mammalian and fission yeast Rap1 to interact with TRF2 and Taz1, respectively, to mediate telomere protection. In contrast, in budding yeast this module recruits Sir3 to telomeres to mediate transcriptional silencing.

    • Yong Chen
    • Rekha Rai
    • Ming Lei
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 213-221