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Showing 551–600 of 700 results

Advanced filters: Author: D B Salisbury Clear advanced filters

Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

There is an urgent need for drugs, therapies and vaccines to be available to protect the human population against COVID-19. One of the first approaches taken in the COVID-19 global response was to consider repurposing licensed drugs. This commentary highlights an extraordinary international collaborative effort of independent researchers who have recently all come to the same conclusion—that chloroquine or hydroxchloroquine are unlikely to provide clinical benefit against COVID-19.

S. G. P. Funnell
W. E. Dowling
C. M. Coleman
Comments & OpinionOpen Access26 Aug 2020
Nature Communications

Volume: 11, P: 1-4
BRG1/SMARCA4 is essential for neuroblastoma cell viability through modulation of cell death and survival pathways

L Jubierre
A Soriano
M F Segura
Research21 Mar 2016
Oncogene

Volume: 35, P: 5179-5190
Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease

Ahmed A. Z. Dawoud
Rodney D. Gilbert
Nicholas C. P. Cross
ResearchOpen Access19 Aug 2021
Leukemia

Volume: 36, P: 507-515
Single-cell sequencing reveals the landscape of the human brain metastatic microenvironment

Single-cell transcriptomic analysis of brain metastatic samples from 5 patients suggests a central role for fibroblasts in remodeling tumor microenvironments through the type I collagen signaling axis.

Qianqian Song
Jimmy Ruiz
Jing Su
ResearchOpen Access21 Jul 2023
Communications Biology

Volume: 6, P: 1-13
Author Correction: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma

Molly Went
Amit Sud
Richard S. Houlston
Amendments and CorrectionsOpen Access10 Jan 2019
Nature Communications

Volume: 10, P: 1-3
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells

A B Fielding
S Lim
S Dedhar
Research13 Sept 2010
Oncogene

Volume: 30, P: 521-534
Antitumoral effect of interleukin-12-secreting fibroblasts in a mouse model of ovarian cancer: Implications for the use of ovarian cancer biopsy-derived fibroblasts as a vehicle for regional gene therapy

Raquel Sanches
Marcel Kuiper
Yves-Jean Bignon
Research15 Jun 2000
Cancer Gene Therapy

Volume: 7, P: 707-720
A resonant cavity system for exposing cell cultures to intense pulsed RF fields

Masood Ur-Rehman
Yasir Alfadhl
Iain Scott
ResearchOpen Access19 Mar 2022
Scientific Reports

Volume: 12, P: 1-18
Natural history of NF1 c.2970_2972del p.(Met992del): confirmation of a low risk of complications in a longitudinal study

Claire Forde
Emma Burkitt-Wright
Meena Upadhyaya
ResearchOpen Access13 Dec 2021
European Journal of Human Genetics

Volume: 30, P: 291-297
The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ERα, and is an independent prognostic factor in node-negative breast cancer

D J Brennan
D P O'Connor
W M Gallagher
Research05 Dec 2011
Oncogene

Volume: 31, P: 3483-3494
FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway

M Asad
M K Wong
R Y-J Huang
ResearchOpen Access17 Jul 2014
Cell Death & Disease

Volume: 5, P: e1346
Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo

T E Bapiro
K K Frese
F M Richards
ResearchOpen Access29 May 2014
British Journal of Cancer

Volume: 111, P: 318-325
Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors

N Echeverry
G Ziltener
E Felley-Bosco
ResearchOpen Access07 May 2015
Cell Death & Disease

Volume: 6, P: e1757
Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy

Xuan Wang
Molei Liu
Katherine P. Liao
ResearchOpen Access05 Apr 2024
Scientific Reports

Volume: 14, P: 1-12
Temporin L and aurein 2.5 have identical conformations but subtly distinct membrane and antibacterial activities

Giorgia Manzo
Philip M. Ferguson
A. James Mason
ResearchOpen Access29 Jul 2019
Scientific Reports

Volume: 9, P: 1-13
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
Effects of the Y Chromosome on Cardiovascular Risk Factors in Japanese Men

Yumiko Hiura
Yasue Fukushima
Naoharu Iwai
Research01 Sept 2008
Hypertension Research

Volume: 31, P: 1687-1694
The role of the nuclear Akt activation and Akt inhibitors in all-trans-retinoic acid-differentiated HL-60 cells

K Matkovic
F Brugnoli
D Visnjic
Research13 Apr 2006
Leukemia

Volume: 20, P: 941-951
The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

V Thewes
R Simon
M Tönjes
Research20 Mar 2017
Oncogene

Volume: 36, P: 4124-4134
The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed–Sternberg cells

H Knecht
B Sawan
S Mai
Research27 Nov 2008
Leukemia

Volume: 23, P: 565-573
A comparison of host gene expression signatures associated with infection in vitro by the Makona and Ecran (Mayinga) variants of Ebola virus

Andrew Bosworth
Stuart D. Dowall
Julian A. Hiscox
ResearchOpen Access27 Feb 2017
Scientific Reports

Volume: 7, P: 1-15
Cancer risk in patients with constitutional chromosome deletions: a nationwide British cohort study

A J Swerdlow
M J Schoemaker
P A Jacobs
ResearchOpen Access27 May 2008
British Journal of Cancer

Volume: 98, P: 1929-1933
Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle

Bernardo Villarreal-Ramos
Stefan Berg
Stephen V. Gordon
ResearchOpen Access17 Jan 2018
Scientific Reports

Volume: 8, P: 1-13
Differences in host immune populations between rhesus macaques and cynomolgus macaque subspecies in relation to susceptibility to Mycobacterium tuberculosis infection

Laura Sibley
Owen Daykin-Pont
Sally Sharpe
ResearchOpen Access23 Apr 2021
Scientific Reports

Volume: 11, P: 1-9
Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma

L Chiecchio
R K M Protheroe
F M Ross
Research06 Jul 2006
Leukemia

Volume: 20, P: 1610-1617
Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression

M D Bullock
K M Pickard
A H Mirnezami
ResearchOpen Access20 Jun 2013
Cell Death & Disease

Volume: 4, P: e684
Dimensional phenotypic analysis and functional categorisation of mutations reveal novel genotype–phenotype associations in Rett syndrome

Tony Charman
Tracey C S Neilson
Mark E S Bailey
Research03 Aug 2005
European Journal of Human Genetics

Volume: 13, P: 1121-1130
Functional expression of thymidine kinase in human leukaemic and colorectal cells, delivered as EGFP fusion protein by herpesvirus saimiri-based vector

Jennifer H Hoggarth
Elena Jones
David M Meredith
Research09 Jul 2004
Cancer Gene Therapy

Volume: 11, P: 613-624
Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-¹³C]pyruvate and [1,4-¹³C₂]fumarate

T H Witney
M I Kettunen
K M Brindle
ResearchOpen Access05 Oct 2010
British Journal of Cancer

Volume: 103, P: 1400-1406
A non-human primate in vitro functional assay for the early evaluation of TB vaccine candidates

Rachel Tanner
Andrew D. White
Helen McShane
ResearchOpen Access04 Jan 2021
npj Vaccines

Volume: 6, P: 1-11
Ovarian hyperstimulation induces centrosome amplification and aneuploid mammary tumors independently of alterations in p53 in a transgenic mouse model of breast cancer

E L Milliken
K L Lozada
R A Keri
Research24 Sept 2007
Oncogene

Volume: 27, P: 1759-1766
TAK1-regulated expression of BIRC3 predicts resistance to preoperative chemoradiotherapy in oesophageal adenocarcinoma patients

G Piro
S Giacopuzzi
D Melisi
ResearchOpen Access20 Aug 2015
British Journal of Cancer

Volume: 113, P: 878-885
In silico modelling to differentiate the contribution of sugar frequency versus total amount in driving biofilm dysbiosis in dental caries

David Head
Deirdre A. Devine
P. D. Marsh
ResearchOpen Access12 Dec 2017
Scientific Reports

Volume: 7, P: 1-10
In vitro analysis of ovarian cancer response to cisplatin, carboplatin, and paclitaxel identifies common pathways that are also associated with overall patient survival

E Bicaku
Y Xiong
J M Lancaster
ResearchOpen Access17 May 2012
British Journal of Cancer

Volume: 106, P: 1967-1975
Response of esophageal cancer cells to epigenetic inhibitors is mediated via altered thioredoxin activity

Theresa D Ahrens
Sylvia Timme
Silke Lassmann
Research21 Dec 2015
Laboratory Investigation

Volume: 96, P: 307-316
Analysis of chronic myeloid leukaemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission

Katerina Machova Polakova
Hana Zizkova
Andreas Hochhaus
Research29 May 2020
Leukemia

Volume: 34, P: 2113-2124
G-protein-coupled receptors and cancer

G-protein-coupled receptors (GPCRs) influence many steps in tumorigenesis, including proliferation, survival, angiogenesis, metastasis and evasion of the immune system. This Review provides an overview of the various roles of GPCRs in cancer and their potential as therapeutic targets.

Robert T. Dorsam
J. Silvio Gutkind
Reviews01 Feb 2007
Nature Reviews Cancer

Volume: 7, P: 79-94
Label-free optical vibrational spectroscopy to detect the metabolic state of M. tuberculosis cells at the site of disease

Vincent O. Baron
Mingzhou Chen
Stephen H. Gillespie
ResearchOpen Access29 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation

Anthony M. Cirrincione
Adriana D. Pellegrini
Sandra Rieger
ResearchOpen Access04 Mar 2020
Scientific Reports

Volume: 10, P: 1-12
Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors

Y Xu
T Brenn
D W Melton
ResearchOpen Access05 Jan 2012
British Journal of Cancer

Volume: 106, P: 553-561
F14512, a polyamine-vectorized anti-cancer drug, currently in clinical trials exhibits a marked preclinical anti-leukemic activity

A Kruczynski
A Pillon
N Guilbaud
Research09 Apr 2013
Leukemia

Volume: 27, P: 2139-2148
Tumour suppressive properties of fibroblast growth factor receptor 2-IIIb in human bladder cancer

David Ricol
David Cappellen
François Radvanyi
Research08 Dec 1999
Oncogene

Volume: 18, P: 7234-7243
FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Gisella Figlioli
Amandine Billaud
Paolo Peterlongo
ResearchOpen Access27 Jan 2023
European Journal of Human Genetics

Volume: 31, P: 578-587
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium

Hisani N. Horne
Hannah Oh
Jonine D. Figueroa
ResearchOpen Access26 Apr 2018
Scientific Reports

Volume: 8, P: 1-11
Narrowing the gap for hematopoietic stem cell transplantation in the East-Mediterranean/African region: comparison with global HSCT indications and trends

Helen Baldomero
Mahmoud Aljurf
Nicolas Novitzky
Research06 Aug 2018
Bone Marrow Transplantation

Volume: 54, P: 402-417
Hypoxia- and radiation-activated Cre/loxP ‘molecular switch’ vectors for gene therapy of cancer

O Greco
M C Joiner
S D Scott
Research24 Nov 2005
Gene Therapy

Volume: 13, P: 206-215
Enhanced pseudotyping efficiency of HIV-1 lentiviral vectors by a rabies/vesicular stomatitis virus chimeric envelope glycoprotein

D C J Carpentier
K Vevis
N D Mazarakis
Research08 Sept 2011
Gene Therapy

Volume: 19, P: 761-774
International Care programs for Pediatric Post-COVID Condition (Long COVID) and the way forward

Caroline L. H. Brackel
Lieke C. E. Noij
Suzanne W. J. Terheggen-Lagro
Research29 Jan 2024
Pediatric Research

Volume: 96, P: 319-324
Genomic analysis of respiratory syncytial virus infections in households and utility in inferring who infects the infant

Charles N. Agoti
My V. T. Phan
D. James Nokes
ResearchOpen Access11 Jul 2019
Scientific Reports

Volume: 9, P: 1-14
ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models

Lambe, Spencer, Thomas, Gilbert and colleagues report on the detailed immune profile of rhesus macaques and ferrets vaccinated against SARS-CoV-2 under high dose challenge. Their findings indicate that the ChAdOx1 nCoV-19 (AZD1222) the vaccine induces immune responses and reduces disease symptoms in both models, including SARS-CoV-2 mediated pneumonia and virus shedding.

Teresa Lambe
Alexandra J. Spencer
Sarah C. Gilbert
ResearchOpen Access26 Jul 2021
Communications Biology

Volume: 4, P: 1-12

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