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Showing 1–50 of 92 results

Advanced filters: Author: D Bar-Sagi Clear advanced filters

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

N. Li
A. Batzer
J. Schlessinger
Research06 May 1993
Nature

Volume: 363, P: 85-88
Cooperative nutrient scavenging is an evolutionary advantage in cancer

Nutrient-starved tumour cells cooperate by secreting aminopeptidases that digest oligopeptides in the microenvironment, creating a shared pool of free amino acids.

Gizem Guzelsoy
Setiembre D. Elorza
Carlos Carmona-Fontaine
ResearchOpen Access19 Feb 2025
Nature

Volume: 640, P: 534-542
The ras protein is not associated with exocytosis

V. ADAM-VIZI
D. KNIGHT
A. HALL
Research13 Aug 1987
Nature

Volume: 328, P: 581
Control of exocytosis

Robert D. Burgoyne
News & Views09 Jul 1987
Nature

Volume: 328, P: 112-113
Direct coupling of the cell cycle and cell death machinery by E2F

Zaher Nahle
Julia Polakoff
Scott W. Lowe
Research21 Oct 2002
Nature Cell Biology

Volume: 4, P: 859-864
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Oncogenic Ras has previously been shown to promote macropinocytosis; here it is demonstrated that this process allows tumour cells to use extracellular proteins to generate amino acids necessary to support tumour growth.

Cosimo Commisso
Shawn M. Davidson
Dafna Bar-Sagi
Research12 May 2013
Nature

Volume: 497, P: 633-637
K-ras activation generates an inflammatory response in lung tumors

H Ji
A M Houghton
K-K Wong
Research14 Nov 2005
Oncogene

Volume: 25, P: 2105-2112
Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer

M E Caldwell
G M DeNicola
D A Tuveson
Research22 Aug 2011
Oncogene

Volume: 31, P: 1599-1608
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Blockade of ERK signaling in KRAS-mutant pancreatic cancer increases the dependence on autophagic flux through different mechanisms and provides a rationale for combinatorial targeting with autophagy inhibitors.

Kirsten L. Bryant
Clint A. Stalnecker
Channing J. Der
Research04 Mar 2019
Nature Medicine

Volume: 25, P: 628-640
Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

Amplification of wild-type KRAS in a subset of gastroesophageal tumors drives intrinsic resistance to MAPK inhibition that can be overcome by combined targeting of MEK and SHP2.

Gabrielle S. Wong
Jin Zhou
Adam J. Bass
Research28 May 2018
Nature Medicine

Volume: 24, P: 968-977
Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis

A whole-genome short interfering RNA screen identified vacuolar ATPase as a regulator of macropinocytosis induced by oncogenic RAS, a key determinant of tumour cell growth under nutrient-limiting conditions.

Craig Ramirez
Andrew D. Hauser
Dafna Bar-Sagi
Research11 Dec 2019
Nature

Volume: 576, P: 477-481
PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer

PD-L1 on tumor cells exerts an important dampening effect on T cells via their expression of PD-1. Miller and colleagues find that PD-L1 ‘back-signaling’ into T cells and macrophages can also dampen immune responses within the tumor microenvironment.

Brian Diskin
Salma Adam
George Miller
Research09 Mar 2020
Nature Immunology

Volume: 21, P: 442-454
Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos

Hiroaki Terasawa
Daisuke Kohda
Fuyuhiko Inagaki
Research01 Dec 1994
Nature Structural Biology

Volume: 1, P: 891-897
Ras/Rap effector specificity determined by charge reversal

Nicolas Nassar
Gudrun Horn
Alfred Wittinghofer
Research01 Aug 1996
Nature Structural Biology

Volume: 3, P: 723-729
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

Gideon Bollag
D. Wade Clapp
Kevin Shannon
Research01 Feb 1996
Nature Genetics

Volume: 12, P: 144-148
RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1

Stella Tommasi
Reinhard Dammann
Gerd P Pfeifer
Research24 Apr 2002
Oncogene

Volume: 21, P: 2713-2720
Positive selection of T lymphocytes on fibroblasts

Tomasz Pawlowski
Jill D. Elliott
Uwe D. Staerz
Research12 Aug 1993
Nature

Volume: 364, P: 642-645
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

Jiri Lukas
David Parry
Jiri Bartek
Research08 Jun 1995
Nature

Volume: 375, P: 503-506
Production of ‘hybrid’ antibiotics by genetic engineering

D. A. Hopwood
F. Malpartida
S. Ōmura
Research18 Apr 1985
Nature

Volume: 314, P: 642-644
Downregulation of enkephalin-mediated inflammatory responses by CDl0/neutral endopeptidase 24.11

Margaret A. Shipp
George B. Stefano
Ellis L. Reinherz
Research27 Sept 1990
Nature

Volume: 347, P: 394-396
Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria

Carol L. Francis
Timothy A. Ryan
Stanley Falkow
Research12 Aug 1993
Nature

Volume: 364, P: 639-642
Prolonged vs transient roles for early cell cycle signaling components

David W Rose
Sen Xiao
Jerrold M Olefsky
Research18 Aug 1998
Oncogene

Volume: 17, P: 889-899
Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1

Trever G. Bivona
Ignacio Pérez de Castro
Mark R. Philips
Research29 Jun 2003
Nature

Volume: 424, P: 694-698
Correction: Corrigendum: Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome

Marco Tartaglia
Len A Pennacchio
Bruce D Gelb
Amendments and Corrections01 Feb 2007
Nature Genetics

Volume: 39, P: 276
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-κB signaling

Macus Tien Kuo
Zesheng Liu
Hitoshi Unate
Research22 Mar 2002
Oncogene

Volume: 21, P: 1945-1954
Nucleolar Arf sequesters Mdm2 and activates p53

Jason D. Weber
Laura J. Taylor
Dafna Bar-Sagi
Research01 May 1999
Nature Cell Biology

Volume: 1, P: 20-26
Medical large language models are vulnerable to data-poisoning attacks

Large language models can be manipulated to generate misinformation by poisoning of a very small percentage of the data on which they are trained, but a harm mitigation strategy using biomedical knowledge graphs can offer a method for addressing this vulnerability.

Daniel Alexander Alber
Zihao Yang
Eric Karl Oermann
ResearchOpen Access08 Jan 2025
Nature Medicine

Volume: 31, P: 618-626
Evaluation of a monoclonal antibody to ras peptide, RAP-5, claimed to bind preferentially to cells of infiltrating carcinomas

A Robinson
A R Williams
A H Wyllie
Research01 Dec 1986
British Journal of Cancer

Volume: 54, P: 877-883
MACHETE identifies interferon-encompassing chromosome 9p21.3 deletions as mediators of immune evasion and metastasis

Barriga et al. develop MACHETE, a genome engineering strategy enabling the flexible modeling of megabase-sized deletions and show that the concomitant loss of the interferon cluster with CDKN2A/B deletions on 9p21.3 enhances immune evasion.

Francisco M. Barriga
Kaloyan M. Tsanov
Scott W. Lowe
ResearchOpen Access07 Nov 2022
Nature Cancer

Volume: 3, P: 1367-1385
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome

This is an issue edsumm for ng1939. Identification of the Palaeocene/Eocene thermal maximum in a marine sedimentary sequence. It shows that sea surface temperatures near the North Pole increased from roughly 18 degrees Celsius to over 23 degrees Celsius — such warm values imply the absence of ice and thus exclude the influence of ice-albedo feedbacks on this Arctic warming.

Marco Tartaglia
Len A Pennacchio
Bruce D Gelb
Research03 Dec 2006
Nature Genetics

Volume: 39, P: 75-79
Mutual requirement of CDK4 and Myc in malignant transformation: evidence for cyclin D1/CDK4 and p16^INK4A as upstream regulators of Myc

Kirsten Haas
Peter Staller
Tarik Möröy
Research10 Jul 1997
Oncogene

Volume: 15, P: 179-192
Modulation of signalling by Sprouty: a developing story

Hong Joo Kim
Dafna Bar-Sagi
Reviews01 Jun 2004
Nature Reviews Molecular Cell Biology

Volume: 5, P: 441-450
Enforced CDK4 expression in a hematopoietic cell line confers resistance to the G1 arrest induced by ionizing radiation

Michael F Reed
Vivian F Liu
Mark E Ewen
Research09 Dec 1998
Oncogene

Volume: 17, P: 2961-2971
Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: a novel transgenic murine model for medullary thyroid carcinoma

D Johnston
D Hatzis
M E Sunday
Research23 Jan 1998
Oncogene

Volume: 16, P: 167-177
Regulation of cellular response to cisplatin-induced DNA damage and DNA repair in cells overexpressing p185^erbB-2 is dependent on the ras signaling pathway

Lily Yen
Nie Zeng-Rong
Moulay A Alaoui-Jamali
Research17 Apr 1997
Oncogene

Volume: 14, P: 1827-1835
Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells

B Liu
M Fang
Z Fan
ResearchOpen Access17 Jul 2001
British Journal of Cancer

Volume: 85, P: 303-311
Transformation by ras modifies AP1 composition and activity

Fatima Mechta
Dominique Lallemand
Moshe Yaniv
Research20 Feb 1997
Oncogene

Volume: 14, P: 837-847
Oncogenesis and altered differentiation induced by activated Ras in neuroblasts of transgenic mice

David A Sweetser
Raj P Kapur
Richard D Palmiter
Research04 Dec 1997
Oncogene

Volume: 15, P: 2783-2794
EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

R Bonavia
M M Inda
F B Furnari
Research05 Dec 2011
Oncogene

Volume: 31, P: 4054-4066
Transformation fingerprint: induced STAT3-C, v-Src and Ha-Ras cause small initial changes but similar established profiles in mRNA

Keren Paz
Nicholas D Socci
James E Darnell
Research20 Sept 2004
Oncogene

Volume: 23, P: 8455-8463
RAS oncogenes: weaving a tumorigenic web

The RAS oncogenes have far-reaching effects when they are oncogenically mutated. This Review discusses our current knowledge about the cell-autonomous and non-cell-autonomous effects of oncogenic RAS and how different RAS isoforms and substitutions seem to have different effects.

Yuliya Pylayeva-Gupta
Elda Grabocka
Dafna Bar-Sagi
Reviews13 Oct 2011
Nature Reviews Cancer

Volume: 11, P: 761-774
The dark side of Ras: regulation of apoptosis

Adrienne D Cox
Channing J Der
Reviews08 Dec 2003
Oncogene

Volume: 22, P: 8999-9006
Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

Using a device implanted in KRAS-driven pancreatic tumors, authors demonstrate that cancer cells incorporate proteins in their microenvironment as a source of amino acids. This work provides a novel approach to study tumor metabolism that could be applied with therapeutic purposes.

Shawn M Davidson
Oliver Jonas
Matthew G Vander Heiden
Research26 Dec 2016
Nature Medicine

Volume: 23, P: 235-241
A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families

A M Goldstein
L Liu
J P Struewing
ResearchOpen Access14 Aug 2001
British Journal of Cancer

Volume: 85, P: 527-530
Identification of a dominant-negative mutation in the yeast CDC25 guanine nucleotide exchange factor for Ras

Weonmee Park
Raymond D Mosteller
Daniel Broek
Research20 Feb 1997
Oncogene

Volume: 14, P: 831-836
Identification of a second Grb2 binding site in the v-Fms tyrosine kinase

Annalisa Mancini
Rainer Niedenthal
Teruko Tamura
Research25 Sept 1997
Oncogene

Volume: 15, P: 1565-1572
FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

Ashley E Sims
Elizabeth Spiteri
Tony T Huang
Research25 Apr 2007
Nature Structural & Molecular Biology

Volume: 14, P: 564-567
The mechanism involved in the regulation of phospholipase Cγ1 activity in cell migration

Enza Piccolo
Pasquale F Innominato
Marco Falasca
Research17 Sept 2002
Oncogene

Volume: 21, P: 6520-6529
A role for the small GTPase Rac in polyomavirus middle-T antigen-mediated activation of the serum response element and in cell transformation

Marc Urich
Mathias Senften
Kurt Ballmer-Hofer
Research13 Mar 1997
Oncogene

Volume: 14, P: 1235-1241
The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression

S Vonlanthen
J Heighway
D C Betticher
ResearchOpen Access15 May 2001
British Journal of Cancer

Volume: 84, P: 1372-1376

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