Daniel Batlle and colleagues present an approach to the diagnosis and evaluation of hyponatremia that is based on the often-underused concept of electrolyte-free water clearance. Illustrated by a case vignette, this approach is set in the context of emerging evidence supporting the utility of vasopressin receptor antagonists in the management of hyponatremia. The pharmacology, mechanism of action, and efficacy data for drugs of this class are reviewed.
- Sheldon Chen
- Nishant Jalandhara
- Daniel Batlle
