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Showing 251–300 of 748 results

Advanced filters: Author: D C Mccormick Clear advanced filters

How do the GTPases really work?

Determination of the pK_a values of the γ-phosphate in p21^ras mutants provides the first experimental evidence for substrate-assisted catalysis in the intrinsic GTPase reaction.

Rolf Hilgenfeld
News & Views01 Jan 1995
Nature Structural Biology

Volume: 2, P: 3-6
Large-Scale Affinity Chromatography

Yannis D. Clonis
Research01 Dec 1987
Bio/Technology

Volume: 5, P: 1290-1293
Impact of warmer climate periods on flood hazard in the European Alps

Moderate flooding in the European Alps declined during past warmer periods, whereas extreme floods both increased and decreased, according to an analysis of palaeoflood records.

B. Wilhelm
W. Rapuc
S. B. Wirth
Research27 Jan 2022
Nature Geoscience

Volume: 15, P: 118-123
Characterization of two classes of small molecule inhibitors of Arp2/3 complex

The actin cytoskeleton plays a critical role in cell biological processes such as cell adhesion, migration and endocytosis. Polymerization of actin filaments directed by the actin-related protein (Arp)2/3 complex supports many types of cellular movement. Two classes of small molecules that bind to different sites on the Arp2/3 complex and inhibit its ability to nucleate actin filaments are now described; these inhibitors provide a powerful approach for studying the Arp2/3 complex in living cells.

B. J. Nolen
N. Tomasevic
T. D. Pollard
Research02 Aug 2009
Nature

Volume: 460, P: 1031-1034
Retinoids, breast cancer and NK cells

ML Villa
E Ferrario
E Clerici
Research01 Nov 1993
British Journal of Cancer

Volume: 68, P: 845-850
Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis

Nitric oxide deficiency promotes tuberculosis through increased neutrophilic inflammation.

Bibhuti B. Mishra
Rustin R. Lovewell
Christopher M. Sassetti
Research15 May 2017
Nature Microbiology

Volume: 2, P: 1-11
Reversible coordinative binding and separation of sulfur dioxide in a robust metal–organic framework with open copper sites

Metal–organic framework capture materials could reduce the environmental impact of SO₂ emissions but can have limited stability and poor reversibility. Here, a metal–organic framework with open Cu(ii) sites with fully reversible SO₂ uptake of 17.5 mmol g⁻¹ under ambient conditions is reported.

Gemma L. Smith
Jennifer E. Eyley
Martin Schröder
Research14 Oct 2019
Nature Materials

Volume: 18, P: 1358-1365
Abnormal Pyruvate and α-Ketoglutarate Dehydrogenase Complexes in a Patient with Lactic Acidemia

Yasuhiro Kuroda
Jeffrey J Kline
Ted D Groshong
Research01 Aug 1979
Pediatric Research

Volume: 13, P: 928-931
Acoustic enrichment can enhance fish community development on degraded coral reef habitat

Healthy coral reefs have an acoustic signature known to be attractive to coral and fish larvae during settlement. Here the authors use playback experiments in the field to show that healthy reef sounds can increase recruitment of juvenile fishes to degraded coral reef habitat, suggesting that acoustic playback could be used as a reef management strategy.

Timothy A. C. Gordon
Andrew N. Radford
Stephen D. Simpson
ResearchOpen Access29 Nov 2019
Nature Communications

Volume: 10, P: 1-7
Backscattering from the Upper Atmosphere (75–160 km) detected by Optical Radar

P. D. MCCORMICK
S. K. POULTNEY
J. A. PERSCHY
Research01 Feb 1966
Nature

Volume: 209, P: 798-799
Wheat Fhb1 encodes a chimeric lectin with agglutinin domains and a pore-forming toxin-like domain conferring resistance to Fusarium head blight

Bikram Gill and colleagues report map-based cloning of Fhb1, which confers resistance to Fusarium head blight in wheat. They show that the PFT gene at Fhb1 confers resistance and encodes a chimeric lectin with agglutinin domains and a pore-forming toxin domain, identifying a new type of durable plant-resistance gene.

Nidhi Rawat
Michael O Pumphrey
Bikram S Gill
Research24 Oct 2016
Nature Genetics

Volume: 48, P: 1576-1580
Crystal structure of RhoA–GDP and its functional implications

RhoA, a ubiquitous intracellular GTPase, mediates cytoskeletal responses to extracellular signals. A 2.1 Å resolution crystal structure of the human RhoA–GDP complex shows unique stereochemistry in the switch I region, which results in a novel mode of Mg2+ binding.

Yunyi Wei
Yan Zhang
Zygmunt S. Derewenda
Correspondence01 Sept 1997
Nature Structural Biology

Volume: 4, P: 699-703
Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome

Staphylococcal superantigens are potent activators of T cells, causing toxic shock syndrome and death. But surprisingly few staphylococcal infections of humans are associated with TSS, even though the bacteria produce the superantigen toxins. Joaquin Madrenas and his colleagues report that other components of the bacteria can downregulate the superantigen-induced T cell activation, protecting the host from death by TSS.

Thu A Chau
Michelle L McCully
Joaquín Madrenas
Research24 May 2009
Nature Medicine

Volume: 15, P: 641-648
Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue

Complete RNA isoforms are captured by a new single-nuclei sequencing method.

Simon A. Hardwick
Wen Hu
Hagen U. Tilgner
ResearchOpen Access07 Mar 2022
Nature Biotechnology

Volume: 40, P: 1082-1092
Antagonistic properties against Fusarium sporotrichioides and glycosylation of HT-2 and T-2 toxins by selected Trichoderma strains

Marta Modrzewska
Dominik Popowski
Magdalena Twarużek
ResearchOpen Access11 Mar 2024
Scientific Reports

Volume: 14, P: 1-11
Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

K.A. McAllister
K.M. Grogg
D.A. Marchuk
Research01 Dec 1994
Nature Genetics

Volume: 8, P: 345-351
Frequent activation of N-myc genes by hepadnavirus insertion in woodchuck liver tumours

Geneviève Fourel
Christian Trepo
Marie-Annick Buendia
Research20 Sept 1990
Nature

Volume: 347, P: 294-298
Beyond a phenomenological description of magnetostriction

Although magnetostriction is universal in magnetic materials, understanding its microscopic origin remains challenging. Here the authors use X-ray and ultrafast electron diffraction to separate the material’s sub-picosecond spin and lattice responses and reveal the magnetoelastic stress generated by demagnetization.

A. H. Reid
X. Shen
H. A. Dürr
ResearchOpen Access26 Jan 2018
Nature Communications

Volume: 9, P: 1-9
Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins

Magdalena Koziczak
Thomas Holbro
Nancy E Hynes
Research29 Apr 2004
Oncogene

Volume: 23, P: 3501-3508
Ancient DNA from the skeletons of Roopkund Lake reveals Mediterranean migrants in India

Remains of several hundred humans are scattered around Roopkund Lake, situated over 5,000 meters above sea level in the Himalayan Mountains. Here the authors analyze genome-wide data from 38 skeletons and find 3 clusters with different ancestries and dates, showing the people were desposited in multiple catastrophic events.

Éadaoin Harney
Ayushi Nayak
Niraj Rai
ResearchOpen Access20 Aug 2019
Nature Communications

Volume: 10, P: 1-10
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice

Ludan Xiang
Qian Wu
Zhihui Huang
ResearchOpen Access22 Jul 2022
Cell Death & Disease

Volume: 13, P: 1-11
Housing policies and energy efficiency spillovers in low and moderate income communities

Evaluating the sustainability impacts of housing policies for low- and moderate-income households is challenging. This study links observations of housing programme participation and utility consumption to quantify the benefits of locally administered housing policies in a typical community in the American Southeast.

Omar Isaac Asensio
Olga Churkina
Kira E. O’Hare
ResearchOpen Access18 Mar 2024
Nature Sustainability

Volume: 7, P: 590-601
Imaging RNA polymerase III transcription using a photostable RNA–fluorophore complex

A highly photostable RNA mimic of red fluorescent protein, Corn, was designed and used to image RNA polymerase III transcription. Quantitative imaging of Corn-tagged transcripts revealed transcription dynamics in live cells following mTOR inhibition.

Wenjiao Song
Grigory S Filonov
Samie R Jaffrey
Research25 Sept 2017
Nature Chemical Biology

Volume: 13, P: 1187-1194
Home or surgery based screening for chronic obstructive pulmonary disease (COPD)?

D A Seamark
S Williams
David M. G. Halpin
Research01 Jun 2001
Primary Care Respiratory Journal

Volume: 10, P: 30-33
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation

Melnick and colleagues show that the cohesin complex exhibits dose-dependent regulation of chromatin remodeling that accompanies the transition of germinal center B cells to plasma cells, which is necessary to prevent lymphomagenesis.

Martín A. Rivas
Cem Meydan
Ari M. Melnick
Research11 Jan 2021
Nature Immunology

Volume: 22, P: 240-253
Specific changes in rasGAP-associated 62 kilodalton protein during integrin mediated cell-substrate interaction

Sreenath V Sharma
Artashes Boyajian
Hirofumi Nakano
Research05 Jun 1997
Oncogene

Volume: 14, P: 2641-2649
Label-free characterization of organic nanocarriers reveals persistent single molecule cores for hydrocarbon sequestration

In-situ methods are important for investigating the local structure and function in molecular nanostructures but such investigations often involve laborious labeling methods that can disrupt behavior or are not fast enough to capture stimuli-responsive phenomena. Here, the authors use X-rays resonant with molecular bonds to demonstrate an in-situ nanoprobe that eliminates the need for labels and enables data collection times within seconds.

Terry McAfee
Thomas Ferron
Brian A. Collins
ResearchOpen Access25 May 2021
Nature Communications

Volume: 12, P: 1-10
Greenhouse gas emissions from diverse Arctic Alaskan lakes are dominated by young carbon

A spatially extensive survey of lake CH₄ and CO₂ emissions in Arctic Alaska shows the source material to be primarily relatively young organic matter (up to about 3,500 years old). Contributions from ancient C sources were twice as large in fine textured sediments.

Clayton D. Elder
Xiaomei Xu
Claudia I. Czimczik
Research29 Jan 2018
Nature Climate Change

Volume: 8, P: 166-171
Retinoic acid causes an anteroposterior transformation in the developing central nervous system

A. J. Durston
J. P. M. Timmermans
P. D. Nieuwkoop
Research13 Jul 1989
Nature

Volume: 340, P: 140-144
The Food Safety of Transgenic Animals

David B. Berkowitz
Research01 Sept 1990
Bio/Technology

Volume: 8, P: 819-825
Reduced Plasma Somatomedin Activity and Costal Cartilage Sulfate Incorporation Activity during Experimental Growth Retardation in the Fetal Rat

F A De Prins
D J Hill
R D G Milner
Research01 Nov 1984
Pediatric Research

Volume: 18, P: 1100-1104
Antibodies targeting Cancer stem cells, A novel pattern in Immunotherapy

Sarfaraz Alam
ResearchOpen Access23 Dec 2010
Nature Precedings

P: 1
Cooling and societal change during the Late Antique Little Ice Age from 536 to around 660 AD

Societal upheaval occurred across Eurasia in the sixth and seventh centuries. Tree-ring reconstructions suggest a period of pronounced cooling during this time associated with several volcanic eruptions.

Ulf Büntgen
Vladimir S. Myglan
Alexander V. Kirdyanov
Research08 Feb 2016
Nature Geoscience

Volume: 9, P: 231-236
Dose-Related Suppression of REM Sleep and PGO Waves by the Serotonin-1 Agonist Eltoprazine

James J. Quattrochi
Adam N. Mamelak
J. Allan Hobson
Research01 Jan 1993
Neuropsychopharmacology

Volume: 8, P: 7-13
Comparative Study of X-Ray and UV Induced Cytotoxicity, DNA Repair, and Mutagenesis in Down's Syndrome and Normal Fibroblasts

L P Yotti
T W Glover
D J Segal
Research01 Feb 1980
Pediatric Research

Volume: 14, P: 88-92
Insulin Stimulates Amino Acid and Lipid Metabolism in Isolated Fetal Rat Hepatocytes

John D Miller
Madhur K Sinha
Supriya Ganguli
Research01 Jul 1986
Pediatric Research

Volume: 20, P: 609-612
Disturbance of Cerebral Oxygenation and Hemodynamics Related to the Opening of the Bypass Bridge during Veno-Arterial Extracorporeal Membrane Oxygenation

K D Liem
L A A Kollée
B Oeseburg
Research01 Jul 1995
Pediatric Research

Volume: 38, P: 124-129
Inhibition of integrin linked kinase (ILK) suppresses β-catenin-Lef/Tcf-dependent transcription and expression of the E-cadherin repressor, snail, in APC−/− human colon carcinoma cells

Clara Tan
Penny Costello
Shoukat Dedhar
Research17 Jan 2001
Oncogene

Volume: 20, P: 133-140
Quantum correlations between light and the kilogram-mass mirrors of LIGO

Quantum correlations between the laser beams and the positions of the 40-kg mirrors of LIGO are confirmed experimentally, enabling high-precision measurements of both gravitational waves and macroscopic quantum states.

Haocun Yu
L. McCuller
J. Zweizig
Research01 Jul 2020
Nature

Volume: 583, P: 43-47
The concentration of HCG in the plasma and spinal fluid of patients with trophoblastic tumours in the central nervous system

A G Rushworth
A H Orr
K D Bagshawe
Research01 Jun 1968
British Journal of Cancer

Volume: 22, P: 253-257
8-Cl-cAMP antagonizes mitogen-activated protein kinase activation and cell growth stimulation induced by epidermal growth factor

A Budillon
E Di Gennaro
P Tagliaferri
ResearchOpen Access12 Nov 1999
British Journal of Cancer

Volume: 81, P: 1134-1141
Neonatal Isolation Stress Potentiates Cocaine Seeking Behavior in Adult Male and Female Rats

Wendy J Lynch
Lauren D Mangini
Jane R Taylor
Research27 Oct 2004
Neuropsychopharmacology

Volume: 30, P: 322-329
Vitamin E therapy in retinopathy of prematurity

D P R Muller
Research01 Mar 1992
Eye

Volume: 6, P: 221-225
The role of vmPFC in accessing the temporality of life events for mental time travel

Angelo Pisani
Giulia Franco
Elisa Ciaramelli
ResearchOpen Access24 Apr 2025
Scientific Reports

Volume: 15, P: 1-12
The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate β-catenin/TCF-4 signaling

Susanne Dihlmann
Anja Siermann
Magnus von Knebel Doeberitz
Research25 Mar 2001
Oncogene

Volume: 20, P: 645-653
Bone Mineral Density of the Lumbar Spine in White Mediterranean Spanish Children and Adolescents: Changes Related to Age, Sex, and Puberty

L Del Rio
A Carrascosa
F M Domenech
Research01 Mar 1994
Pediatric Research

Volume: 35, P: 362-365
Sulindac sulfide inhibits Ras signaling

Christian Herrmann
Christoph Block
Oliver Müller
Research09 Oct 1998
Oncogene

Volume: 17, P: 1769-1776
Epidermal Growth Factor in Neonatal Mouse Urine: Maturative Effect of Thyroxine

J Perheentupa
J Lakshmanan
D A Fisher
Research01 Nov 1984
Pediatric Research

Volume: 18, P: 1080-1084
Genome editing of the vermilion locus generates a visible eye color marker for Oncopeltus fasciatus

Katie Reding
Minh Lê
Leslie Pick
ResearchOpen Access14 Mar 2023
Scientific Reports

Volume: 13, P: 1-14

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