A high phosphate diet accelerates cisplatin–induced acute kidney injury (AKI) progression to chronic kidney disease (CKD). Aging, male gender, and Klotho deficiency exacerbate and Klotho administration mitigates CKD progression, mineral disorders, and cardiovasculopathy. This is a technically simple model to study AKI-to-CKD transition, complications of CKD, and potential therapies.
- Mingjun Shi
- Kathryn L. McMillan
- Ming Chang Hu
