Findings in animal models of Huntington's disease and levodopa-induced dyskinesia indicate that corticostriatal long-term potentiation is abnormally stable in these conditions, causing persistent inhibition of the output nuclei of the basal ganglia, which leads to involuntary movements. In this article, Centonze et al. review evidence that repetitive transcranial magnetic stimulation can interfere with the maintenance of corticostriatal long-term potentiation in humans, and might, therefore, be useful as an antidyskinetic treatment.
- Diego Centonze
- Giorgio Bernardi
- Giacomo Koch
