Nature Search

Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study

Artificial intelligence (AI) system is known to improve dermatologists’ diagnostic accuracy for melanoma. This group applies the eye-tracking technology on dermatologists when diagnosing dermoscopic images of melanomas and reports improved balanced diagnostic accuracy when using an X(explainable) AI system comparing to the standard one.

Tirtha Chanda
Sarah Haggenmueller
Titus J. Brinker
ResearchOpen Access21 May 2025
Nature Communications

Volume: 16, P: 1-10
Perspectives on climate change in South Asia

Home to roughly a quarter of the world’s population, South Asia is a hotspot for global warming impacts. In this Viewpoint, nine researchers from South Asia discuss the progress made in understanding and responding to climate change in the region.

T. S. Amjath-Babu
Nausheen H. Anwar
Chandni Singh
Reviews26 Sept 2025
Nature Climate Change

Volume: 15, P: 1025-1030
Pathologist-like explainable AI for interpretable Gleason grading in prostate cancer

An inherently explainable AI trained on 1,015 expert-annotated prostate tissue images achieved strong Gleason pattern segmentation while providing interpretable outputs and addressing interobserver variability in pathology.

Gesa Mittmann
Sara Laiouar-Pedari
Titus J. Brinker
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-17
Synthesis of Kawain

D. KOSTERMANS
Research04 Nov 1950
Nature

Volume: 166, P: 788-789
Fast and pervasive diagenetic isotope exchange in foraminifera tests is species-dependent

Paleoclimate reconstructions commonly use oxygen isotope compositions from fossil foraminifera tests as proxies. Here, the authors show that these tests exchange O-isotopes with surrounding fluids, with implications for paleotemperature records.

Deyanira Cisneros-Lazaro
Arthur Adams
Anders Meibom
ResearchOpen Access10 Jan 2022
Nature Communications

Volume: 13, P: 1-11
Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization

Michael D. Lubeck
Robert Natuk
Marjorie Robert-Guroff
Research01 Jun 1997
Nature Medicine

Volume: 3, P: 651-658
Reply to: False conflict and false confirmation errors are crucial components of AI accuracy in medical decision making

Christoph Wies
Katja Hauser
Titus J. Brinker
ResearchOpen Access13 Aug 2024
Nature Communications

Volume: 15, P: 1-3
Crystallographic and spectroscopic characterization and reactivities of a mononuclear non-haem iron(III)-superoxo complex

Non-haem iron superoxo species—proposed as key intermediates in catalytic activation of molecular oxygen—have proven difficult to structurally characterize. Here, the authors obtain crystallographic and spectral characterization of a non-haem iron(III)-superoxo species and subsequently study its reactivity.

Seungwoo Hong
Kyle D. Sutherlin
Wonwoo Nam
Research16 Dec 2014
Nature Communications

Volume: 5, P: 1-7
VLBI structures of the images of the double QSO 0957 + 561

R. W. Porcas
R. S. Booth
P. N. Wilkinson
Research26 Feb 1981
Nature

Volume: 289, P: 758-762
Green nanotechnology of MGF-AuNPs for immunomodulatory intervention in prostate cancer therapy

Menka Khoobchandani
Aslam Khan
Kattesh V. Katti
ResearchOpen Access18 Aug 2021
Scientific Reports

Volume: 11, P: 1-30
Fossil biocalcite remains open to isotopic exchange with seawater for tens of millions of years

Deyanira Cisneros-Lazaro
Arthur Adams
Anders Meibom
ResearchOpen Access22 Oct 2024
Scientific Reports

Volume: 14, P: 1-11
How does adrenaline accelerate the heart?

H. F. BROWN
D. DIFRANCESCO
S. J. NOBLE
Research01 Jul 1980
Nature

Volume: 280, P: 235-236
Coding of facial expressions of pain in the laboratory mouse

The mouse grimace scale offers a standardized behavioral coding system to study the subjective pain experience in mice.

Dale J Langford
Andrea L Bailey
Jeffrey S Mogil
Research09 May 2010
Nature Methods

Volume: 7, P: 447-449
Association of Glucose, Arabinose and Xylose in Jute

D. B. DAS
M. K. MITRA
J. F. WAREHAM
Research04 Apr 1953
Nature

Volume: 171, P: 613-614
Stability in Flight

D'ARCY W. THOMPSON
Research22 Feb 1917
Nature

Volume: 98, P: 490-491
Induction of synapse formation by de novo neurotransmitter synthesis

Neuronal communication relies on matching different neurostransmitter types with their appropriate receptors. The authors here demonstrate that release of a novel neurotransmitter from presynaptic terminals can induce both the accumulation and activation of its corresponding receptors on postsynaptic neurons.

Scott R. Burlingham
Nicole F. Wong
Soham Chanda
ResearchOpen Access01 Jun 2022
Nature Communications

Volume: 13, P: 1-15
Graft-versus-host disease impairs cerebellar growth

W. S. T. GRIFFIN
J. R. HEAD
C. CARROL
Research28 Sept 1978
Nature

Volume: 275, P: 315-317
Dermatologist-like explainable AI enhances trust and confidence in diagnosing melanoma

Artificial intelligence has become popular as a cancer classification tool, but there is distrust of such systems due to their lack of transparency. Here, the authors develop an explainable AI system which produces text- and region-based explanations alongside its classifications which was assessed using clinicians’ diagnostic accuracy, diagnostic confidence, and their trust in the system.

Tirtha Chanda
Katja Hauser
Titus J. Brinker
ResearchOpen Access15 Jan 2024
Nature Communications

Volume: 15, P: 1-17
Adrenal Pathology

D. EXLEY
Books & Arts23 May 1970
Nature

Volume: 226, P: 776-777
Science convergence in affective research is associated with impactful multidisciplinary appeal rather than multidisciplinary content

Affective research generates more diverse citations that cover a higher variety of research fields when compared to cognitive research. This occurs despite a more narrow focus of topics included in the original affective articles themselves

Vitalii Zhukov
Alexander M. Petersen
Ioannis Pavlidis
ResearchOpen Access04 Sept 2024
Communications Psychology

Volume: 2, P: 1-9
Electroconvulsive shock treatment decreases β-adrenergic receptor sensitivity in rat brain

GHANSHYAM N. PANDEY
WILLIAM J. HEINZE
JOHN M. DAVIS
Research01 Jul 1980
Nature

Volume: 280, P: 234-235
Live imaging of airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread

Becker et al. use live imaging of SARS-CoV-2 infected airway epithelium cultures to demonstrate a dual role for mucociliary clearance in viral spread. Initially, virus goes with the mucus flow, facilitating local spread; later, increased mucus secretion and ciliary motion defects limit spread.

Mark E. Becker
Laura Martin-Sancho
Thomas J. Hope
ResearchOpen Access02 Nov 2024
Nature Communications

Volume: 15, P: 1-17
Selective spider toxins reveal a role for the Na_v1.1 channel in mechanical pain

Two spider toxins are shown to target the Na_v1.1 subtype of sodium channel specifically, shedding light on the role of these channels in mechanical pain signalling.

Jeremiah D. Osteen
Volker Herzig
David Julius
Research06 Jun 2016
Nature

Volume: 534, P: 494-499
Reaction with Iodine of Polysaccharides dissolved in Strong Calcium Chloride Solution

BLANCHE D. E. GAILLARD
R. W. BAILEY
Research08 Oct 1966
Nature

Volume: 212, P: 202-203
Transformation of mononuclear phagocytes in vivo and malignant histiocytosis caused by a novel murine spleen focus-forming virus

T. Franz
J. Löhler
W. Ostertag
Research09 May 1985
Nature

Volume: 315, P: 149-151
Detection of Antibodies to Human T-Cell Lymphotropic Virus-III (HTLV-III) with an Immunoassay Employing a Recombinant Escherichia coli-Derived Viral Antigenic Peptide

Tse Wen Chang
Ikunoshin Kato
Nancy T. Chang
Research01 Oct 1985
Bio/Technology

Volume: 3, P: 905-909
Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation

This study identifies regulators of the RNA sensor RIG-I. Diverse processes, including the unfolded protein response, Wnt signalling and RNA metabolism, modulate this pathway. The splicing regulator KHSRP is identified as a negative regulator of RIG-I that affects influenza replication in vivo.

Stephen Soonthornvacharin
Ariel Rodriguez-Frandsen
Sumit K. Chanda
Research01 Mar 2017
Nature Microbiology

Volume: 2, P: 1-13
Glycerol-3-phosphate is a critical mobile inducer of systemic immunity in plants

Pradeep Kachroo and colleagues show that glycerol-3-phosphate is a critical mobile inducer of systemic acquired resistance in plants.

Bidisha Chanda
Ye Xia
Pradeep Kachroo
Research27 Mar 2011
Nature Genetics

Volume: 43, P: 421-427
Identification of global inhibitors of cellular glycosylation

Here, the authors discover small molecules that inhibit glycosylation processes that occur in the Golgi apparatus of cells. The molecules reversibly inhibit formation of elaborate glycan structures without affecting secretion of glycoproteins.

Daniel Madriz Sørensen
Christian Büll
Yoshiki Narimatsu
ResearchOpen Access20 Feb 2023
Nature Communications

Volume: 14, P: 1-19
Global landscape of HIV–human protein complexes

Affinity tagging, mass spectroscopy and a tailor-made scoring system are used to identify 497 high-confidence interactions between human proteins and human immunodeficiency virus proteins.

Stefanie Jäger
Peter Cimermancic
Nevan J. Krogan
Research21 Dec 2011
Nature

Volume: 481, P: 365-370
Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response

Oral squamous cell carcinoma is known to contain altered tumour cells within both the tumour core and leading edge. Here, the authors utilise spatial transcriptomics to characterise differences in gene expression and ligand-receptor architecture between areas of the tumour.

Rohit Arora
Christian Cao
Pinaki Bose
ResearchOpen Access18 Aug 2023
Nature Communications

Volume: 14, P: 1-19
Using mortuary and burial data to place COVID-19 in Lusaka, Zambia within a global context

Estimates of COVID-19 impacts in many low- and middle-income countries remain very uncertain, with lack of high-quality data. Here, the authors reconstruct epidemic dynamics in Lusaka, Zambia and estimate that, when accounting for demographic patterns, the epidemic severity is comparable with global norms.

Richard J. Sheppard
Oliver J. Watson
Christopher J. Gill
ResearchOpen Access29 Jun 2023
Nature Communications

Volume: 14, P: 1-15
Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes

Lee, Mall et al. explore why the sequence-related transcription factors Myod1 and Ascl1 lead to different reprogramming outcomes when expressed in fibroblasts, despite binding similar targets.

Qian Yi Lee
Moritz Mall
Marius Wernig
Research30 Mar 2020
Nature Cell Biology

Volume: 22, P: 401-411
Multiple elements of soil biodiversity drive ecosystem functions across biomes

Combining field data from 83 sites on five continents, together with microcosm experiments, the authors show that nutrient cycling, decomposition, plant production and other ecosystem functions are positively associated with a higher diversity of a wide range of soil organisms.

Manuel Delgado-Baquerizo
Peter B. Reich
Brajesh K. Singh
Research03 Feb 2020
Nature Ecology & Evolution

Volume: 4, P: 210-220
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

The anti-leprosy drug clofazimine inhibits coronavirus replication in several cell models and shows potent antiviral activity against SARS-CoV-2 infection in a hamster model, particularly when used in combination with remdesivir.

Shuofeng Yuan
Xin Yin
Kwok-Yung Yuen
Research16 Mar 2021
Nature

Volume: 593, P: 418-423
The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors

The orphan nuclear receptor SHP is a transcriptional corepressor in the liver. Jo and colleagues show that it also acts to negatively regulate Toll-like receptor signaling at multiple levels.

Jae-Min Yuk
Dong-Min Shin
Eun-Kyeong Jo
Research03 Jul 2011
Nature Immunology

Volume: 12, P: 742-751
A probability-based approach for the analysis of large-scale RNAi screens

Renate König
Chih-yuan Chiang
Sumit K Chanda
Research09 Sept 2007
Nature Methods

Volume: 4, P: 847-849
AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

AMPK integrates information about a cell’s energy status to inform decisions about cellular processes, including autophagy. Here the authors identify cyclin Y as an AMPK substrate, which phosphorylates cyclin Y and promotes its interaction with CDK16 to stimulate autophagy.

Marc Dohmen
Sarah Krieg
Jörg Vervoorts
ResearchOpen Access25 Feb 2020
Nature Communications

Volume: 11, P: 1-18
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

A screen of the ReFRAME library of approximately 12,000 known drugs for antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) identified several candidate compounds with suitable activities and pharmacological profiles, which could potentially expedite the deployment of therapies for coronavirus disease 2019 (COVID-19).

Laura Riva
Shuofeng Yuan
Sumit K. Chanda
Research24 Jul 2020
Nature

Volume: 586, P: 113-119
A robust deep learning framework for multiclass skin cancer classification

Burhanettin Ozdemir
Ishak Pacal
ResearchOpen Access10 Feb 2025
Scientific Reports

Volume: 15, P: 1-19
Safety evaluation of Asparagus racemosus: a commonly used herb of Ayurvedic Medicine in Charles Foster rats

Narayan Yadav
Debabrata Chanda
D Mani
MultimediaOpen Access23 Feb 2012
Nature Precedings

P: 1
Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana

Athanasios Theologis
Joseph R. Ecker
Ronald W. Davis
Research14 Dec 2000
Nature

Volume: 408, P: 816-820
When the ice age seemed to end

PETER D. MOORE
News & Views20 Sept 1974
Nature

Volume: 251, P: 185-186
Accelerated discovery of eutectic compositionally complex alloys by generative machine learning

Z. Q. Chen
Y. H. Shang
Y. Yang
ResearchOpen Access03 Sept 2024
npj Computational Materials

Volume: 10, P: 1-12
Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression

Mammalian Rap1 protein is found to have a non-telomeric function in regulating the substrate specificity of IKKs towards the p65 subunit of NF-κB, leading to NF-κB transcriptional activity.

Hsiangling Teo
Sourav Ghosh
Vinay Tergaonkar
Research11 Jul 2010
Nature Cell Biology

Volume: 12, P: 758-767
Author Correction: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

Laura Riva
Shuofeng Yuan
Sumit K. Chanda
Amendments and Corrections18 Jun 2024
Nature

Volume: 631, P: E3
Ultraviolet radiation protection potentials of Methylene Blue for human skin and coral reef health

Zheng-Mei Xiong
Xiaojing Mao
Kan Cao
ResearchOpen Access28 May 2021
Scientific Reports

Volume: 11, P: 1-9
Author Correction: Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates

Moritz Mall
Michael S. Kareta
Marius Wernig
Amendments and Corrections04 Jun 2024
Nature

Volume: 630, P: E11
A functional genomics approach to the mode of action of apratoxin A

Hendrik Luesch
Sumit K Chanda
Peter G Schultz
Research12 Feb 2006
Nature Chemical Biology

Volume: 2, P: 158-167
MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis

Dipanjan Chanda
Jieyi Li
Dietbert Neumann
ResearchOpen Access09 Sept 2016
Experimental & Molecular Medicine

Volume: 48, P: e258

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