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Showing 151–200 of 486 results

Advanced filters: Author: D Esposito Clear advanced filters

Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) lead to accumulation of proteins aggregates in airways. Mutated CFTR promotes transglutaminases-mediated crosslinking of beclin 1, a positive regulator of autophagy, to induce accumulation of LC3-binding protein p62 and prevent autophagic degradation of aggregates.

Alessandro Luciani
Valeria Rachela Villella
Luigi Maiuri
Research15 Aug 2010
Nature Cell Biology

Volume: 12, P: 863-875
Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease

Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.

Julie Gonneaud
Alex T. Baria
Etienne Vachon-Presseau
ResearchOpen Access09 Sept 2021
Nature Communications

Volume: 12, P: 1-17
Displacement MMG-based estimation of dynamic muscle viscoelasticity in the quadriceps during passive pedaling

Shinichi Fukuhara
Hisao Oka
ResearchOpen Access28 Jan 2025
Scientific Reports

Volume: 15, P: 1-11
Nonequilibrium charge-density-wave order beyond the thermal limit

Photo-induced phase transitions triggered by an ultrafast excitation cannot be described within the quasi-equilibrium framework. Here, using time-resolved experimental probes, the authors report a transient charge-density-wave order in TbTe₃ and describe it using a model with a non-equilibrium transition temperature.

J. Maklar
Y. W. Windsor
L. Rettig
ResearchOpen Access03 May 2021
Nature Communications

Volume: 12, P: 1-8
The auroral footprint of Enceladus on Saturn

Wayne R. Pryor
Abigail M. Rymer
Xiaoyan Zhou
Research20 Apr 2011
Nature

Volume: 472, P: 331-333
Temporal dynamics of brain activation during a working memory task

Jonathan D. Cohen
William M. Perlstein
Edward E. Smith
Research10 Apr 1997
Nature

Volume: 386, P: 604-608
Human leukocyte antigen variants associate with BNT162b2 mRNA vaccine response

Esposito et al. investigate the genetic basis of response to BNT162b2 mRNA COVID-19 vaccine in 1351 Italian subjects. They find variants in the human leukocyte antigen locus significantly associate with serum anti-SARS-CoV-2 antibody levels, after vaccination.

Martina Esposito
Francesca Minnai
Francesca Colombo
ResearchOpen Access04 Apr 2024
Communications Medicine

Volume: 4, P: 1-7
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

The bromodomain and extraterminal (BET) inhibitor JQ1 synergizes with the histone deacetylase inhibitor SAHA to suppress tumor growth in mouse models of pancreatic cancer.

Pawel K Mazur
Alexander Herner
Jens T Siveke
Research21 Sept 2015
Nature Medicine

Volume: 21, P: 1163-1171
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy

As an interface between maternal and fetal tissues, decidua hosts immune cells specialized in fostering a successful pregnancy. Here the authors carry out high-dimensional characterization of function, morphology and surface markers of human decidual innate lymphoid cells (ILCs), identifying subsets with features distinct from blood ILC.

Oisín Huhn
Martin A. Ivarsson
Francesco Colucci
ResearchOpen Access20 Jan 2020
Nature Communications

Volume: 11, P: 1-14
Author Correction: Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

Eline Pecho-Vrieseling
Claus Rieker
Francesco Paolo Di Giorgio
Amendments and Corrections17 Jul 2018
Nature Neuroscience

Volume: 21, P: 1291
Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

Trans-neuronal transfer of pathogenic proteins has been demonstrated in multiple neurodegenerative diseases. Here the authors show in vitro and in a mouse model that mutant Huntingtin is also transferred from one neuron to another. This transfer requires exocytosis machinery and contributes to neurodegeneration.

Eline Pecho-Vrieseling
Claus Rieker
Francesco Paolo Di Giorgio
Research13 Jul 2014
Nature Neuroscience

Volume: 17, P: 1064-1072
Reporting of sources of funding in systematic reviews in periodontology and implant dentistry

C. M. Faggion Jr
M. Atieh
D. G. Zanicotti
Comments & Opinion06 Feb 2014
British Dental Journal

Volume: 216, P: 109-112
Surname and Y chromosome in Southern Europe: a case study with Colom/Colombo

Luis Javier Martínez-González
Esther Martínez-Espín
José Antonio Lorente
Research17 Aug 2011
European Journal of Human Genetics

Volume: 20, P: 211-216
Extreme early-life anxiety is associated with an evolutionarily conserved reduction in the strength of intrinsic functional connectivity between the dorsolateral prefrontal cortex and the central nucleus of the amygdala

R M Birn
A J Shackman
N H Kalin
Research24 Jul 2014
Molecular Psychiatry

Volume: 19, P: 853
Author Correction: Non-equilibrium pathways to emergent polar supertextures

Vladimir A. Stoica
Tiannan Yang
John W. Freeland
Amendments and Corrections14 Oct 2024
Nature Materials

Volume: 23, P: 1759
Retrieval of vector integration sites from cell-free DNA

A new approach called liquid biopsy integration site sequencing enables monitoring of genetically modified cells in solid tissues of patients receiving gene therapy.

Daniela Cesana
Andrea Calabria
Eugenio Montini
Research17 Jun 2021
Nature Medicine

Volume: 27, P: 1458-1470
B cell receptor signal strength determines B cell fate

Stefano Casola
Kevin L Otipoby
Klaus Rajewsky
Research01 Feb 2004
Nature Immunology

Volume: 5, P: 317-327
Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate

Bisphosphoglycerate mutase (BPGM) drives phosphoglycerate mutase 1 (PGAM1) phosphorylation, which is required for glycolytic flux. Loss of BPGM is partially compensated by 1,3-BPG directly phosphorylating PGAM1, sustaining glycolytic flux but diverting metabolites for serine synthesis.

Rob C Oslund
Xiaoyang Su
Joshua D Rabinowitz
Research07 Aug 2017
Nature Chemical Biology

Volume: 13, P: 1081-1087
Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148

Genetic variants at multiple loci of chr5p15.33 have been associated with susceptibility to numerous cancers. Here the authors show that the association of one of these loci may be explained by a variant, rs36115365, influencing telomerase reverse transcriptase (TERT) expression via ZNF148.

Jun Fang
Jinping Jia
Laufey T. Amundadottir
ResearchOpen Access27 Apr 2017
Nature Communications

Volume: 8, P: 1-17
Subdissociative Dose Ketamine Produces a Deficit in Manipulation but not Maintenance of the Contents of Working Memory

Rebekah A E Honey
Danielle C Turner
P C Fletcher
Research19 Jun 2003
Neuropsychopharmacology

Volume: 28, P: 2037-2044
Acute Ketamine Administration Alters the Brain Responses to Executive Demands in a Verbal Working Memory Task: an fMRI Study

R A E Honey
G D Honey
P C Fletcher
Research21 Apr 2004
Neuropsychopharmacology

Volume: 29, P: 1203-1214
Cell type specific long non-coding RNA targets identified by integrative analysis of single-cell and bulk colorectal cancer transcriptomes

Ante Mihaljevic
Philip D. Rubin
Roberta Esposito
ResearchOpen Access13 May 2024
Scientific Reports

Volume: 14, P: 1-9
Evolutionary recruitment of flexible Esrp-dependent splicing programs into diverse embryonic morphogenetic processes

Epithelial-mesenchymal interplays are essential to many ontogenetic processes in vertebrates. Here Burguera et al. show diverse embryonic morphogenetic processes regulated by Epithelial Splicing Regulatory Protein (Esrp) in different deuterostome species.

Demian Burguera
Yamile Marquez
Manuel Irimia
ResearchOpen Access27 Nov 2017
Nature Communications

Volume: 8, P: 1-15
Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging

Mark D'Esposito
Leon Y. Deouell
Adam Gazzaley
Reviews01 Nov 2003
Nature Reviews Neuroscience

Volume: 4, P: 863-872
A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer

Roland Rad and colleagues report development of a new conditional piggyBac transposition system for performing insertional mutagenesis screens in mice. They apply the system to identify new oncogenic driver pathways for pancreatic cancer.

Roland Rad
Lena Rad
Allan Bradley
Research08 Dec 2014
Nature Genetics

Volume: 47, P: 47-56
Is the rostro-caudal axis of the frontal lobe hierarchical?

Studies into the role of different frontal cortex areas in cognitive control have suggested that there is a rostral-to-caudal processing gradient. Drawing on anatomical and functional data from humans and monkeys, Badre and D'Esposito discuss whether this gradient might reflect a hierarchical organization.

David Badre
Mark D'Esposito
Reviews12 Aug 2009
Nature Reviews Neuroscience

Volume: 10, P: 659-669
Current drive at plasma densities required for thermonuclear reactors

Future tokamak nuclear fusion reactors depend on efficient current drive methods, but it is hard to penetrate the high-density plasma in these devices. In this paper the authors show that radio frequency waves coupled to lower hybrid plasma waves, when the peripheral temperature of the plasma is high, can penetrate the plasma core.

R. Cesario
L. Amicucci
F. Zonca
Research10 Aug 2010
Nature Communications

Volume: 1, P: 1-10
Breakpoint junction features of seven DMD deletion mutations

Niall P. Keegan
Steve D. Wilton
Sue Fletcher
ResearchOpen Access22 Aug 2019
Human Genome Variation

Volume: 6, P: 1-7
100 years ago

D. WETTERHAN
News & Views19 Mar 1981
Nature

Volume: 290, P: 192
Monocot characters

Peter D. Moore
Books & Arts01 Sept 1982
Nature

Volume: 299, P: 92
Publisher Correction: Comparison of the Hi-C, GAM and SPRITE methods using polymer models of chromatin

Luca Fiorillo
Francesco Musella
Mario Nicodemi
Amendments and CorrectionsOpen Access03 Sept 2021
Nature Methods

Volume: 18, P: 1266
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

Pawel K. Mazur
Alexander Herner
Jens T. Siveke
Amendments and Corrections30 May 2024
Nature Medicine

Volume: 30, P: 2090
Precise detection of circular dichroism in a cluster of nano-helices by photoacoustic measurements

Alessio Benedetti
Badrul Alam
Concita Sibilia
ResearchOpen Access12 Jul 2017
Scientific Reports

Volume: 7, P: 1-7
A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis

Genome-wide association studies (GWAS) have so far uncovered more than 200 loci for multiple sclerosis (MS). Here, the authors integrate data from various sources for a cell type-specific pathway analysis of MS GWAS results that specifically highlights the involvement of the immune system in disease pathogenesis.

Lohith Madireddy
Nikolaos A. Patsopoulos
Sergio E. Baranzini
ResearchOpen Access20 May 2019
Nature Communications

Volume: 10, P: 1-12
K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions

Sara Chiblak
Brigitte Steinbauer
Karin Müller-Decker
ResearchOpen Access06 Jul 2016
Scientific Reports

Volume: 6, P: 1-13
Investigating the properties of TBA variants with twin thrombin binding domains

Teresa Amato
Antonella Virgilio
Aldo Galeone
ResearchOpen Access24 Jun 2019
Scientific Reports

Volume: 9, P: 1-8
Standardized multi-omics of Earth’s microbiomes reveals microbial and metabolite diversity

This Resource combines amplicon sequencing, shotgun metagenomic sequencing and untargeted metabolomics to provide a global view of microbial–metabolite associations across Earth’s environments.

Justin P. Shaffer
Louis-Félix Nothias
Shan Zhang
ResearchOpen Access28 Nov 2022
Nature Microbiology

Volume: 7, P: 2128-2150
Response to interferon-beta treatment in multiple sclerosis patients: a genome-wide association study

S Mahurkar
M Moldovan
C King
Research22 Mar 2016
The Pharmacogenomics Journal

Volume: 17, P: 312-318
Divertor shaping with neutral baffling as a solution to the tokamak power exhaust challenge

Power exhaust is one of the biggest challenges stopping fusion energy. This article shows experimental evidence for strategically shaping the power exhaust region as a solution to this challenge, utilising physics understanding to strike a balance between engineering complexity and power exhaust benefits, consistent with reduced models and simulations.

Kevin Verhaegh
James Harrison
V. Zamkovska
ResearchOpen Access23 May 2025
Communications Physics

Volume: 8, P: 1-15
A Forcecardiography dataset with simultaneous SCG, Heart Sounds, ECG, and Respiratory signals

Salvatore Parlato
Jessica Centracchio
Emilio Andreozzi
ResearchOpen Access06 Aug 2025
Scientific Data

Volume: 12, P: 1-14
Decreasing of p27^Kip1 and cyclin E protein levels is associated with progression from superficial into invasive bladder cancer

T Kamai
K Takagi
K-I Yoshida
ResearchOpen Access01 May 2001
British Journal of Cancer

Volume: 84, P: 1242-1251
Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease

Alba Di Pardo
Enrico Amico
Vittorio Maglione
ResearchOpen Access24 Jan 2017
Scientific Reports

Volume: 7, P: 1-8
Author Correction: Human neocortical expansion involves glutamatergic neuron diversification

Jim Berg
Staci A. Sorensen
Ed S. Lein
Amendments and CorrectionsOpen Access06 Jan 2022
Nature

Volume: 601, P: E12
APC gene mutations and colorectal adenomatosis in familial adenomatous polyposis

F Ficari
A Cama
P Battista
ResearchOpen Access17 Dec 1999
British Journal of Cancer

Volume: 82, P: 348-353
Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease

Jeffrey X. Xie
Helen Alderson
Steven T. Haller
ResearchOpen Access11 Aug 2017
Scientific Reports

Volume: 7, P: 1-7
The what, where and how of delay activity

The short-term retention of working memory is accompanied by neural delay activity. Sreenivasan and D’Esposito describe how delay activity can be assessed, discuss where in the brain it occurs and why, and examine the possible mechanisms that underlie it.

Kartik K. Sreenivasan
Mark D’Esposito
Reviews13 May 2019
Nature Reviews Neuroscience

Volume: 20, P: 466-481
First identification of bovine hepacivirus in wild boars

Claudio de Martinis
Lorena Cardillo
Giovanna Fusco
ResearchOpen Access08 Jul 2022
Scientific Reports

Volume: 12, P: 1-6
Schilbach–Rott syndrome associated with 9q22.32q22.33 duplication, involving the PTCH1 gene

Paolo Prontera
Daniela Rogaia
Gabriela Stangoni
Research01 Apr 2019
European Journal of Human Genetics

Volume: 27, P: 1260-1266
Effect of a combination of pea protein, grape seed extract and lactic acid in an in vivo model of bacterial vaginosis

Marika Lanza
Sarah Adriana Scuderi
Irene Paterniti
ResearchOpen Access17 Feb 2023
Scientific Reports

Volume: 13, P: 1-9
The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity

Naomi R Driesen
Gregory McCarthy
John H Krystal
Research16 Jul 2013
Neuropsychopharmacology

Volume: 38, P: 2613-2622

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