CLPB is a protein disaggregase that has been linked to human disease. Here, the authors show that in different models of chronic or acute loss of the mitochondrial disaggregase, mitochondrial Ca2+ handling and fusion dynamics are impaired, revealing their dependence on CLPB.
- Donato D’Angelo
- Víctor H. Sánchez-Vázquez
- György Hajnóczky
