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Gene deletion as the cause of α thalassaemia: The severe form of α thalassaemia is caused by a haemoglobin gene deletion

SERGIO OTTOLENGHI
W. GEORGE LANYON
WONG HOCK BOON
Research04 Oct 1974
Nature

Volume: 251, P: 389-392
Haemoglobin Constant Spring—A Chain Termination Mutant ?

J. B. CLEGG
D. J. WEATHERALL
P. F. MILNER
Research10 Dec 1971
Nature

Volume: 234, P: 337-340
High frequencies of α-thalassaemia are the result of natural selection by malaria

J. Flint
A. V. S. Hill
J. B. Clegg
Research19 Jun 1986
Nature

Volume: 321, P: 744-750
Molecular basis for acquired haemoglobin H disease

J. OLD
J. LONGLEY
D. J. WEATHERALL
Research01 Oct 1977
Nature

Volume: 269, P: 524-525
K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin

T. R. RUTHERFORD
J. B. CLEGG
D. J. WEATHERALL
Research01 Jul 1979
Nature

Volume: 280, P: 164-165
Gene deletion as the cause of α thalassaemia: Genetic lesion in homozygous α thalassaemia (hydrops fetalis)

J. M. TAYLOR
ANDREE DOZY
D. TODD
Research04 Oct 1974
Nature

Volume: 251, P: 392-393
Presence of gene for β globin in homozygous β₀ thalassaemia

Paul Tolstoshev
Joan Mitchell
J. B. Clegg
Research15 Jan 1976
Nature

Volume: 259, P: 95-98
Interaction of heterocellular hereditary persistence of foetal haemoglobin with β thalassaemia and sickle cell anaemia

W. G. WOOD
D. J. WEATHERALL
J. B. CLEGG
Research18 Nov 1976
Nature

Volume: 264, P: 247-249
Foetal erythropoiesis in human leukaemia

D. J. WEATHERALL
J. B. CLEGG
J. PRITCHARD
Research23 Oct 1975
Nature

Volume: 257, P: 710-712
Globin Synthesis in Thalassaemia: An in vitro Study

D. J. WEATHERALL
J. B. CLEGG
M. A. NAUGHTON
Research11 Dec 1965
Nature

Volume: 208, P: 1061-1065
Mesoscale functional organization of face and body areas in the macaque brain

Whether higher-order visual areas exhibit a fine-grained functional organization remains poorly understood. Here, the authors use high-resolution fMRI to reveal that category-selective regions in macaques are organized into mesoscale functional units which form distinct long-range mesoscale functional networks.

Qi Zhu
Xiaolian Li
Wim Vanduffel
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-14
Induction of sporulation in Bacillus brevis by peptide antibiotics

HANSJÜRGEN RISTOW
WOLFGANG PSCHORN
UTE WINKEL
Research01 Jul 1979
Nature

Volume: 280, P: 165-166
Haemoglobin Synthesis in β-Thalassaemia

J. B. CLEGG
D. J. WEATHERALL
PRAWASE WASI
Research16 Nov 1968
Nature

Volume: 220, P: 664-668
Haemoglobin Synthesis in α-Thalassaemia (Haemoglobin H Disease)

J. B. CLEGG
D. J. WEATHERALL
Research16 Sept 1967
Nature

Volume: 215, P: 1241-1243
Haemoglobin J Cape Town—α₂ 92 Arginine→Glutamine β₂

M. C. BOTHA
D. BEALE
H. LEHMANN
Research19 Nov 1966
Nature

Volume: 212, P: 792-795
Haemoglobin S and P. falciparum malaria (reply)

G. PASVOL
D. J. WEATHERALL
R. J. M. WILSON
Research01 Aug 1979
Nature

Volume: 280, P: 614
Measurements of unwinding of lac operator by repressor

JAMES C. WANG
MARY D. BARKLEY
SUZANNE BOURGEOIS
Research20 Sept 1974
Nature

Volume: 251, P: 247-249
Haemoglobin J Tongariki is associated with α thalassaemia

J. M. OLD
J. B. CLEGG
P. B. BOOTH
Research25 May 1978
Nature

Volume: 273, P: 319-320
Effects of foetal haemoglobin on susceptibility of red cells to Plasmodium falciparum

G. PASVOL
D. J. WEATHERALL
R. J. M. WILSON
Research10 Nov 1977
Nature

Volume: 270, P: 171-173
Evidence for Hb Lepore-like hybrid globin β chain genes in mice

G. STEINHEIDER
H. MELDERIS
W. OSTERTAG
Research23 Oct 1975
Nature

Volume: 257, P: 712-714
Isolation and partial sequence of recombinant plasmids containing human α-, β- and γ-globin cDNA fragments

P. Little
P. Curtis
R. Williamson
Research22 Jun 1978
Nature

Volume: 273, P: 640-643
Haemoglobin Icaria, a new chain-termination mutant which causes α thalassaemia

J. B. CLEGG
D. J. WEATHERALL
H. TSEVRENIS
Research20 Sept 1974
Nature

Volume: 251, P: 245-247
An Improved Method for the Characterization of Human Haemoglobin Mutants: Identification of α₂β₂^95GLU, Haemoglobin N (Baltimore)

J. B. CLEGG
M. A. NAUGHTON
D. J. WEATHERALL
Research28 Aug 1965
Nature

Volume: 207, P: 945-947
Distribution of RNA Polymerase Activity among the Various Classes of Liver Nuclei

I. R. JOHNSTON
A. P. MATHIAS
D. RIDGE
Research16 Nov 1968
Nature

Volume: 220, P: 668-672
Haemoglobin Köln (β–98 Valine → Methionine): An Unstable Protein Causing Inclusion-Body Anaemia

R. W. CARRELL
H. LEHMANN
H. E. HUTCHISON
Research28 May 1966
Nature

Volume: 210, P: 915-916
Switch from foetal to adult haemoglobin synthesis in normal and hypophysectomised sheep

W. G. WOOD
K. PEARCE
G. S. DAWES
Research23 Dec 1976
Nature

Volume: 264, P: 799-801
A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16

S. T. Reeders
M. H. Breuning
D. J. Weatherall
Research01 Oct 1985
Nature

Volume: 317, P: 542-544
A New Hæmoglobin—J_{a Oxford} Found During a Survey of an English Population

J. LIDDELL
D. BROWN
R. G. HUNTSMAN
Research01 Oct 1964
Nature

Volume: 204, P: 269-270
Hematologic Changes and Hemoglobin Analysis in β Thalassemia Heterozygotes during the First Year of Life

W G Wood
D J Weatherall
G W Marsh
Research01 Apr 1982
Pediatric Research

Volume: 16, P: 286-289
Comparison of Zooplankton Biomass Determinations by Indian Ocean Standard Net, Juday Net and Clarke-Bumpus Sampler

D. J. TRANTER
Research22 Jun 1963
Nature

Volume: 198, P: 1179-1180
Defective synthesis of HbE is due to reduced levels of β^E mRNA

Joanne Traeger
W. G. Wood
P. Wasi
Research04 Dec 1980
Nature

Volume: 288, P: 497-499
Haemoglobin A′₂ : α₂δ₂16 Glycine→Arginine

E. W. BALL
M. J. MEYNELL
A. O. W. STRETTON
Research19 Mar 1966
Nature

Volume: 209, P: 1217-1218
Major rearrangement in the human β-globin gene cluster

R. W. Jones
J. M. Old
D. J. Weatherall
Research07 May 1981
Nature

Volume: 291, P: 39-44
Native American gene flow into Polynesia predating Easter Island settlement

Genomic analyses of DNA from modern individuals show that, about 800 years ago, pre-European contact occurred between Polynesian individuals and Native American individuals from near present-day Colombia, while remote Pacific islands were still being settled.

Alexander G. Ioannidis
Javier Blanco-Portillo
Andrés Moreno-Estrada
Research08 Jul 2020
Nature

Volume: 583, P: 572-577
A novel α-globin gene arrangement in man

D. R. Higgs
J. M. Old
D. J. Weatherall
Research17 Apr 1980
Nature

Volume: 284, P: 632-635
Oxidative phosphorylation is required for cardiomyocyte re-differentiation and long-term fish heart regeneration

Lekkos et al. show that a metabolic switch toward oxidative phosphorylation is required for cardiomyocyte re-differentiation and heart regeneration after injury in fish.

Konstantinos Lekkos
Zhilian Hu
Mathilda T. M. Mommersteeg
ResearchOpen Access01 Oct 2025
Nature Cardiovascular Research

P: 1-18
Separation of the α and β-Chains of Human Haemoglobin

J. B. CLEGG
M. A. NAUGHTON
D. J. WEATHERALL
Research06 Jul 1968
Nature

Volume: 219, P: 69-70
Linkage of β-thalassaemia mutations and β-globin gene polymorphisms with DNA polymorphisms in human β-globin gene cluster

Stuart H. Orkin
Haig H. Kazazian Jr
Patricia J. V. Giardina
Research15 Apr 1982
Nature

Volume: 296, P: 627-631
Breakpoints in the human T-cell antigen receptor α-chain locus in two T-cell leukaemia patients with chromosomal translocations

William H. Lewis
Effie E. Michalopoulos
Tak W. Mak
Research01 Oct 1985
Nature

Volume: 317, P: 544-546
Haemoglobin Synthesis during Human Foetal Development

W. G. WOOD
D. J. WEATHERALL
Research20 Jul 1973
Nature

Volume: 244, P: 162-165
γ-β-Thalassaemia studies showing that deletion of the γ- and δ-genes influences β-globin gene expression in man

L. H. T. Van der Ploeg
A. Konings
R. A. Flavell
Research14 Feb 1980
Nature

Volume: 283, P: 637-642
β-Globin gene inactivation by DNA translocation in γβ-thalassaemi

D. Kioussis
E. Vanin
F. G. Grosveld
Research15 Dec 1983
Nature

Volume: 306, P: 662-666
Thalassemia — a global public health problem

The thalassemias and related genetic diseases pose public health problems for many countries in the next millennium. Will it be possible to apply research results to their control and management on the scale required?

D.J. Weatherall
J.B. Clegg
Comments & Opinion01 Aug 1996
Nature Medicine

Volume: 2, P: 847-849
Hemoglobin α Chain Deficiency in Black Children with Variable Quantities of Hemoglobin Bart's at Birth

C Altay
B Ringelhann
T H J Huisman
Research01 Feb 1977
Pediatric Research

Volume: 11, P: 147-152
Substances depressing the Phagocytic Activity of the Reticulo-Endothelial System

T. NICOL
D. L. J. BILBEY
Research30 Aug 1958
Nature

Volume: 182, P: 606
Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria

G. PASVOL
D. J. WEATHERALL
R. J. M. WILSON
Research17 Aug 1978
Nature

Volume: 274, P: 701-703
Haemoglobin F(Malta): a New Foetal Haemoglobin Variant with a High Incidence in Maltese Infants

M. N. CAUCHI
J. B. CLEGG
D. J. WEATHERALL
Research19 Jul 1969
Nature

Volume: 223, P: 311-313
Rat Brain Glutathione and Pyridoxine Deficiency

M. J. ASHWOOD-SMITH
A. D. SMITH
Research26 Dec 1959
Nature

Volume: 184, P: 2028-2029
Effect of F(ab′)₂ from Rabbit Anti-mouse Lymphocyte IgG on the Graft versus Host Reaction in F₁ Hybrid Mice

J. D. NAYSMITH
K. JAMES
Research01 Jan 1968
Nature

Volume: 217, P: 260-261
A New Haemoglobin, J Toronto (α5 Alanine → Aspartic Acid)

J. H. CROOKSTON
D. BEALE
H. LEHMANN
Research11 Dec 1965
Nature

Volume: 208, P: 1059-1061

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