Nature Search

Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia

In this work, the authors performed a single-cell genotyping and transcriptomics analysis, revealing cell-type-specific and nonautonomous effects of mTOR pathway mutations in mosaic focal cortical dysplasia.

Sara Baldassari
Esther Klingler
Stéphanie Baulac
ResearchOpen Access30 Apr 2025
Nature Neuroscience

Volume: 28, P: 964-972
Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

Sensory input and neuronal activity are crucial for proper morphological development of neurons. Here, Frangeul and colleagues show that membrane excitability is a critical component of dendritic development in mouse somatosensory thalamocortical neurons.

Laura Frangeul
Vassilis Kehayas
Denis Jabaudon
ResearchOpen Access08 Dec 2017
Nature Communications

Volume: 8, P: 1-10
Heterogeneous fates of simultaneously-born neurons in the cortical ventricular zone

Elia Magrinelli
Natalia Baumann
Esther Klingler
ResearchOpen Access11 Apr 2022
Scientific Reports

Volume: 12, P: 1-11
SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development

The closely related Sox5 and Sox6 turn out to perform distinct functions during brain development. Maintenance of the ventricular zone neuroepithelium requires Sox6 in the dorsal and Sox5 in the ventral telencephalon. A portion of the interneurons born in ventral telencephalon then express Sox6, which is necessary for their correct migration and phenotypic differentiation.

Eiman Azim
Denis Jabaudon
Jeffrey D Macklis
Research05 Aug 2009
Nature Neuroscience

Volume: 12, P: 1238-1247
Prenatal thalamic waves regulate cortical area size prior to sensory processing

How sensory maps are formed in the brain is only partially understood. Here the authors describe spontaneous calcium waves that propagate across different sensory nuclei in the embryonic thalamus; disrupting the wave pattern triggers thalamic gene expression changes and eventually alters the size of cortical areas.

Verónica Moreno-Juan
Anton Filipchuk
Guillermina López-Bendito
ResearchOpen Access03 Feb 2017
Nature Communications

Volume: 8, P: 1-14
Cerebral organoids at the air–liquid interface generate diverse nerve tracts with functional output

A modified brain-organoid culture generates extensive axon outgrowth with specific tract-like patterns. Organoid tracts connect neurons across distant sites and can innervate and stimulate co-cultured mouse spinal cord tissue to elicit muscle contractions.

Stefano L. Giandomenico
Susanna B. Mierau
Madeline A. Lancaster
Research18 Mar 2019
Nature Neuroscience

Volume: 22, P: 669-679
Context-specific Enhancement of Glutamate Transmission by Cocaine

Ken Bell
Patricia Duffy
Peter W Kalivas
Research01 Sept 2000
Neuropsychopharmacology

Volume: 23, P: 335-344
SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior

M. Soiza-Reilly
F. J. Meye
P. Gaspar
ResearchOpen Access02 Oct 2018
Molecular Psychiatry

Volume: 24, P: 726-745
Correction: SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior

M. Soiza-Reilly
F. J. Meye
P. Gaspar
Amendments and CorrectionsOpen Access10 Jan 2019
Molecular Psychiatry

Volume: 24, P: 773
Erratum: Excess of serotonin affects neocortical pyramidal neuron migration

O Riccio
M Jacobshagen
A G Dayer
Amendments and Corrections20 Mar 2012
Translational Psychiatry

Volume: 2, P: e95
Excess of serotonin affects neocortical pyramidal neuron migration

O Riccio
M Jacobshagen
A G Dayer
ResearchOpen Access11 Oct 2011
Translational Psychiatry

Volume: 1, P: e47

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