Cells must coordinate cell division with genome replication. Here, the authors combine rapid protein depletion, clinical CDK4/6 inhibitors, and genome-wide EdU sequencing to reveal that the CDK4/6-RB axis ensures timely loading of DNA replication factors in G1 phase in human cells.
- Anastasia Sosenko Piscitello
- Ann-Sofie Nilsson
- Bennie Lemmens
