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Showing 1–50 of 655 results

Advanced filters: Author: D Middleton Clear advanced filters

SLC45A4 is a pain gene encoding a neuronal polyamine transporter

The SLC45A4 gene encodes a neuronal polyamine transporter and is linked to pain response in humans and mice.

Steven J. Middleton
Sigurbjörn Markússon
David L. Bennett
ResearchOpen Access20 Aug 2025
Nature

Volume: 646, P: 404-412
Identification of a resistance-exercise-specific signalling pathway that drives skeletal muscle growth

This study demonstrates that the MKK3b/6 signalling pathway drives the skeletal muscle growth-promoting effects of resistance exercise.

Wenyuan G. Zhu
Aaron C. Q. Thomas
Troy A. Hornberger
Research15 May 2025
Nature Metabolism

Volume: 7, P: 1404-1423
Transformation of yeast by a replicating hybrid plasmid

Jean D. Beggs
Research01 Sept 1978
Nature

Volume: 275, P: 104-109
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Francisco Gimeno-Valiente
Carla Castignani
Nnennaya Kanu
ResearchOpen Access10 Sept 2025
Nature Genetics

Volume: 57, P: 2226-2237
Atmospheric Density in the 120—190 km Region Derived from the X-ray Extinction Measured by the U.S. Naval Research Laboratory Satellite 1964-01-D

M. LANDINI
D. RUSSO
G. L. TAGLIAFERRI
Research10 Apr 1965
Nature

Volume: 206, P: 173-174
Reaction of Some Silicates with Chelating Agents

D. A. SUTTON
M. D. MIDDLETON
R. A. F. BODY
Research10 Jan 1959
Nature

Volume: 183, P: 99-100
Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314

The authors highlight the importance of kinetics in GPCR activation. Using solution NMR, they show that the transducer βarrestin1 and the β-arrestin1biased ligand ML314 kinetically tune the conformational ensemble of the neurotensin receptor 1.

Fabian Bumbak
James B. Bower
Joshua J. Ziarek
ResearchOpen Access07 Jun 2023
Nature Communications

Volume: 14, P: 1-14
Weathering of Cæsium-137 in Soil

H. J. GALE
D. L. O. HUMPHREYS
E. M. R. FISHER
Research18 Jan 1964
Nature

Volume: 201, P: 257-261
Ocean Surveys: The Systematic Approach

G. PETER
H. B. STEWART jun.
Research05 Jun 1965
Nature

Volume: 206, P: 1017-1018
Additive Effect of Sub-Threshold Concentrations of Some Organic Compounds Associated with Food Aromas

D. G. GUADAGNI
RON G. BUTTERY
H. K. BURR
Research28 Dec 1963
Nature

Volume: 200, P: 1288-1289
Method for Characterizing Sawfly Egg Pigmentation

D. R. WALLACE
I. M. CAMPBELL
Research01 Sept 1965
Nature

Volume: 207, P: 1363-1364
Bioresorbable, wireless dual stimulator for peripheral nerve regeneration

Wireless bioresorbable stimulators are promising therapeutic implants that naturally dissolve after use. Here, the authors developed a device that operates for months and enables simultaneous multi-site stimulation, preventing early muscle atrophy and accelerating reinnervation in nerve injury models.

Hak-Young Ahn
Jordan B. Walters
John A. Rogers
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-12
Oxford Expedition to Ascension Island, 1964

F. B. ATKINS
P. E. BAKER
D. G. W. SMITH
Research21 Nov 1964
Nature

Volume: 204, P: 722-724
The Tandem Generators of the United Kingdom Atomic Energy Authority

K. W. ALLEN
F. A. JULIAN
J. BLEARS
Research01 Aug 1959
Nature

Volume: 184, P: 303-305
Production of ¹⁰Be and ²⁶Al by cosmic rays in terrestrial quartz in situ and implications for erosion rates

K. Nishiizumi
D. Lal
J. R. Arnold
Research09 Jan 1986
Nature

Volume: 319, P: 134-136
CEACAM1 as a mediator of B-cell receptor signaling in mantle cell lymphoma

Pathological B-cell receptor (BCR) signaling is a key driver of mantle cell lymphoma tumorigenesis. Here, the authors discover that CEACAM1, an immunoglobulin-like transmembrane protein, is essential for a subset of mantle cell lymphoma through activation of the BCR.

Serene Xavier
Vivian Nguyen
Vu N. Ngo
ResearchOpen Access29 May 2025
Nature Communications

Volume: 16, P: 1-18
Separation of ²⁶Al and ²⁶Mg isobars by negative ion mass spectrometry

L. R. Kilius
R. P. Beukens
H. E. Gove
Research01 Nov 1979
Nature

Volume: 282, P: 488-489
Some Distributional Features of the Foot and Mouth Epidemic

W. K. D. DAVIES
G. B. LEWIS
H. A. RANDALL
Research01 Jul 1968
Nature

Volume: 219, P: 121-125
Dietary lipids are largely deposited in skin and rapidly affect insulating properties

The mechanisms underlying the regulation of the skin thermal barrier are poorly understood. Here the authors show that the thermal properties of the skin are reactive to diet and that skin is a target for dietary fat delivery.

Nick Riley
Ildiko Kasza
Caroline M. Alexander
ResearchOpen Access16 May 2025
Nature Communications

Volume: 16, P: 1-17
Whole-genome sequencing of 490,640 UK Biobank participants

A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation and sequence variation.

Keren Carss
Bjarni V. Halldorsson
Ole Schulz-Trieglaff
ResearchOpen Access06 Aug 2025
Nature

Volume: 645, P: 692-701
The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging

The largest harmonized proteomic dataset of plasma, serum and cerebrospinal fluid samples across major neurodegenerative diseases reveals both disease-specific and transdiagnostic proteomic signatures, including a robust plasma profile associated with the APOEε4 genotype.

Farhad Imam
Rowan Saloner
Simon Lovestone
ResearchOpen Access15 Jul 2025
Nature Medicine

Volume: 31, P: 2556-2566
Towards fair decentralized benchmarking of healthcare AI algorithms with the Federated Tumor Segmentation (FeTS) challenge

Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

Maximilian Zenk
Ujjwal Baid
Spyridon Bakas
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-20
Lung cancer burden attributable to ambient particulate matter: a nationally representative population-based case-control study

Rawan A. N. Alhattab
Jennifer M. McKinley
Daniel R. S. Middleton
ResearchOpen Access06 Oct 2025
British Journal of Cancer

P: 1-8
Two physically distinct pores in the dimeric CIC-0 chloride channel

Uwe Ludewig
Michael Pusch
Thomas J. Jentsch
Research26 Sept 1996
Nature

Volume: 383, P: 340-343
A maximum speed of wetting

T. D. Blake
K. J. Ruschak
Research01 Nov 1979
Nature

Volume: 282, P: 489-491
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

Amphetamines are known to enhance extracellular dopamine levels, but the underlying mechanisms are unclear. Utilising a new pH biosensor for synaptic vesicles, the authors show that amphetamines diminish vesicle pH gradients, disrupting dopamine packaging and leading to increased neurotransmitter release.

Zachary Freyberg
Mark S. Sonders
Jonathan A. Javitch
ResearchOpen Access16 Feb 2016
Nature Communications

Volume: 7, P: 1-15
Optical recording of action potentials from vertebrate nerve terminals using potentiometric probes provides evidence for sodium and calcium components

B. M. Salzberg
A. L. Obaid
H. Gainer
Research03 Nov 1983
Nature

Volume: 306, P: 36-40
Alpha-Radioactivity of Human Blood

V. HASSON
R. D. CHERRY
Research07 May 1966
Nature

Volume: 210, P: 591-593
Translocation of Cobalt-60 and Cæsium-137 by Fungi in Agar and Soil Cultures

ERNA GROSSBARD
D. R. STRANKS
Research01 Aug 1959
Nature

Volume: 184, P: 310-314
‘Single-stranded’ DNA from φX174 and M13 is cleaved by certain restriction endonucleases

ROBERT W. BLAKESLEY
ROBERT D. WELLS
Research02 Oct 1975
Nature

Volume: 257, P: 421-422
High Power Radar for Ionospheric Research

J. S. HEY
J. B. G. ROBERTS
C. D. WATKINS
Research30 Nov 1968
Nature

Volume: 220, P: 865-868
Gluconeogenesis by the Human Kidney

G. M. ABER
LORNA O. MORRIS
E. HOUSLEY
Research01 Dec 1966
Nature

Volume: 212, P: 1589-1590
The Advancement of Science and Society

F. R. MOULTON
Research19 Mar 1938
Nature

Volume: 141, P: 517-518
Restriction map of 5S RNA genes of Drosophila melanogaster

JAMES D. PROCUNIER
KENNETH D. TARTOF
Research01 Sept 1976
Nature

Volume: 263, P: 255-257
Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal

A study reports the development of a structural derivative of amphotericin B with broad antifungal activity in mice but without the renal toxicity associated with amphotericin B.

Arun Maji
Corinne P. Soutar
Martin D. Burke
Research08 Nov 2023
Nature

Volume: 623, P: 1079-1085
Textbook of Quantitative Inorganic Analysis Systematic Qualitative Organic Analysis

G. R. D.
Books & Arts17 Jun 1944
Nature

Volume: 153, P: 730
The subducted component in island arc lavas: constraints from Be isotopes and B–Be systematics

J. D. Morris
W. P. Leeman
F. Tera
Research01 Mar 1990
Nature

Volume: 344, P: 31-36
[Book Reviews]

A. D. RITCHIE
Books & Arts01 Apr 1950
Nature

Volume: 165, P: 502
Earthquake-enhanced dissolved carbon cycles in ultra-deep ocean sediments

Earthquakes enhance dissolved carbon production and fuel the microbial activities in hadal trench subsurface sediments, and ultimately strengthen carbon accumulation and transformation in the subduction zones.

Mengfan Chu
Rui Bao
Sarah Zellers
ResearchOpen Access11 Sept 2023
Nature Communications

Volume: 14, P: 1-9
A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer

Gary Middleton
Helen L. Robbins
Lucinda Billingham
ResearchOpen Access11 Mar 2025
npj Precision Oncology

Volume: 9, P: 1-11
Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons

The authors found that dendritic plateau potentials, resulting from the conjunction of EC3 and CA3 inputs, positively modulate existing place fields and induce novel place field formation in CA1 pyramidal neurons. Such a canonical circuit operation may support the formation of spatial maps in the hippocampus and the acquisition of feature selectivity elsewhere in cortex.

Katie C Bittner
Christine Grienberger
Jeffrey C Magee
Research13 Jul 2015
Nature Neuroscience

Volume: 18, P: 1133-1142
Methyl Pentoses in Human Saliva and Dental Plaque

J. D. MIDDLETON
Research25 Apr 1964
Nature

Volume: 202, P: 392-393
Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

Pak et al. show that prolonged fasting is required for the effects of calorie restriction on insulin sensitivity, fuel utilization and ageing in mice.

Heidi H. Pak
Spencer A. Haws
Dudley W. Lamming
Research18 Oct 2021
Nature Metabolism

Volume: 3, P: 1327-1341
Clinical evaluation of a new orthosis, the `Walkabout', for restoration of functional standing and short distance mobility in spinal paralysed individuals

J W Middleton
J D Yeo
K Brigden
Research01 Sept 1997
Spinal Cord

Volume: 35, P: 574-579
Distinct immune cell infiltration patterns in pancreatic ductal adenocarcinoma (PDAC) exhibit divergent immune cell selection and immunosuppressive mechanisms

Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis involving evasion of immune control. Here, the authors perform a comprehensive analysis of single-cell multi-omic data revealing either a myeloid-enriched or adaptive-enriched tumour microenvironment, linked to distinct B and T cell clonal selection and differentiation, distinct overall survival, and potential therapeutic approaches.

Shivan Sivakumar
Ashwin Jainarayanan
Rachael Bashford-Rogers
ResearchOpen Access06 Feb 2025
Nature Communications

Volume: 16, P: 1-20
Chiral metal complexes with large octupolar optical nonlinearities

Christophe Dhenaut
Isabella Ledoux
Hubert Le Bozec
Research23 Mar 1995
Nature

Volume: 374, P: 339-342
Nucleosynthesis of ¹¹B-rich boron in the pre-solar cloud recorded in meteoritic chondrules

Marc Chaussidon
François Robert
Research23 Mar 1995
Nature

Volume: 374, P: 337-339
A silicate weathering mechanism linking increases in marine ⁸⁷Sr/ ⁸⁶Sr with global glaciation

Joel D. Blum
Yigal Erel
Research02 Feb 1995
Nature

Volume: 373, P: 415-418
Nontoxic antimicrobials that evade drug resistance

An amphotericin antifungal that is less toxic to human cells due to its increased capacity for binding the fungal ergosterol over the human cholesterol can still evade resistance mechanisms, challenging the resistance-toxicity yin-yang of antimicrobials.

Stephen A Davis
Benjamin M Vincent
Martin D Burke
Research01 Jun 2015
Nature Chemical Biology

Volume: 11, P: 481-487
Thermal erosion by komatiites at Kambalda, Western Australia and the genesis of nickel ores

D. I. Groves
E. A. Korkiakoski
A. Cowden
Research09 Jan 1986
Nature

Volume: 319, P: 136-139

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