Nature Search

Whole-genome ancestry of an Old Kingdom Egyptian

Whole-genome sequencing of an ancient male Egyptian revealed a mixture of North African Neolithic and eastern Fertile Crescent ancestry, suggesting human migration between Egypt and Mesopotamia by the Old Kingdom period.

Adeline Morez Jacobs
Joel D. Irish
Linus Girdland-Flink
ResearchOpen Access02 Jul 2025
Nature

Volume: 644, P: 714-721
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

Anubha Mahajan
Cassandra N. Spracklen
Andrew P. Morris
Research12 May 2022
Nature Genetics

Volume: 54, P: 560-572
A likelihood-based framework for demographic inference from genealogical trees

gLike infers population demographic histories with a variety of complex admixture events by analysis of graphs of states, which conceptualize the relationships of all lineages found in trees encoded in the ancestral recombination graph.

Caoqi Fan
Jordan L. Cahoon
Charleston W. K. Chiang
Research20 Mar 2025
Nature Genetics

Volume: 57, P: 865-874
Opposite Hand Preferences in Two Sense-modalities

G. ETTLINGER
C. B. BLAKEMORE
A. D. MILNER
Research29 Jun 1968
Nature

Volume: 218, P: 1276
Grey wolf genomic history reveals a dual ancestry of dogs

DNA from ancient wolves spanning 100,000 years sheds light on wolves’ evolutionary history and the genomic origin of dogs.

Anders Bergström
David W. G. Stanton
Pontus Skoglund
ResearchOpen Access29 Jun 2022
Nature

Volume: 607, P: 313-320
Recent ultra-rare inherited variants implicate new autism candidate risk genes

Analysis of whole-genome sequence data from 3,474 families finds an excess of private, likely gene-disrupting variants in individuals with autism. These variants are under purifying selection and suggest candidate genes not previously associated with autism.

Amy B. Wilfert
Tychele N. Turner
Evan E. Eichler
Research26 Jul 2021
Nature Genetics

Volume: 53, P: 1125-1134
The selection landscape and genetic legacy of ancient Eurasians

Analyses of imputed ancient genomes and of samples from the UK Biobank indicate that ancient selection and migration were large contributors to the distribution of phenotypic diversity in present-day Europeans.

Evan K. Irving-Pease
Alba Refoyo-Martínez
Eske Willerslev
ResearchOpen Access10 Jan 2024
Nature

Volume: 625, P: 312-320
A disease-associated gene desert directs macrophage inflammation through ETS2

ETS2—which is associated with inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis—is a central regulator of human inflammatory macrophages.

C. T. Stankey
C. Bourges
J. C. Lee
ResearchOpen Access05 Jun 2024
Nature

Volume: 630, P: 447-456
A linkage disequilibrium-based statistical test for Genome-Wide Epistatic Selection Scans in structured populations

Léa Boyrie
Corentin Moreau
Maxime Bonhomme
Research30 Jul 2020
Heredity

Volume: 126, P: 77-91
Benchtop micro-mashing: high-throughput, robust, experimental beer brewing

Edward D. Kerr
Christopher H. Caboche
Benjamin L. Schulz
ResearchOpen Access15 Jan 2021
Scientific Reports

Volume: 11, P: 1-10
Why rankings of biomedical image analysis competitions should be interpreted with care

Biomedical image analysis challenges have increased in the last ten years, but common practices have not been established yet. Here the authors analyze 150 recent challenges and demonstrate that outcome varies based on the metrics used and that limited information reporting hampers reproducibility.

Lena Maier-Hein
Matthias Eisenmann
Annette Kopp-Schneider
ResearchOpen Access06 Dec 2018
Nature Communications

Volume: 9, P: 1-13
Continent-wide genomic analysis of the African buffalo (Syncerus caffer)

The generation of a de novo contiguous reference genome for the African buffalo reveals that continent wide population structure is influenced by isolation by distance, and signatures of selection suggest a strong effect of infectious disease.

Andrea Talenti
Toby Wilkinson
Liam J. Morrison
ResearchOpen Access29 Jun 2024
Communications Biology

Volume: 7, P: 1-14
Uniaxial compression testing and Cauchy stress modeling to design anatomical silicone replicas

Georges Hattab
Tilman Ahlfeld
Stefanie Speidel
ResearchOpen Access16 Jul 2020
Scientific Reports

Volume: 10, P: 1-7
Author Correction: Why rankings of biomedical image analysis competitions should be interpreted with care

Lena Maier-Hein
Matthias Eisenmann
Annette Kopp-Schneider
Amendments and CorrectionsOpen Access30 Jan 2019
Nature Communications

Volume: 10, P: 1-2
Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant

T L Slatter
N Hung
A W Braithwaite
ResearchOpen Access11 Jun 2015
Cell Death & Disease

Volume: 6, P: e1783
Impaired HDL cholesterol efflux in metabolic syndrome is unrelated to glucose tolerance status: the CODAM study

Wijtske Annema
Arne Dikkers
Uwe J. F. Tietge
ResearchOpen Access08 Jun 2016
Scientific Reports

Volume: 6, P: 1-9
Prognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial

Jochen Gaedcke
Malte Sahrhage
H. Leber
ResearchOpen Access13 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Immunogenicity of 2 therapeutic mosaic HIV-1 vaccine strategies in individuals with HIV-1 on antiretroviral therapy

Boris Julg
Kathryn E. Stephenson
Dan H. Barouch
ResearchOpen Access23 May 2024
npj Vaccines

Volume: 9, P: 1-10
The Dresden in vivo OCT dataset for automatic middle ear segmentation

Peng Liu
Svea Steuer
Marcus Neudert
ResearchOpen Access26 Feb 2024
Scientific Data

Volume: 11, P: 1-7
Early Postnatal Dexamethasone Increases the Risk of Focal Small Bowel Perforation in Extremely Low Birth Weight Infants

Phillip Gordon
Joe Rutledge
David Woodrum
Research23 Dec 1999
Journal of Perinatology

Volume: 19, P: 573-577
Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress

D Speidel
H Helmbold
W Deppert
Research10 Oct 2005
Oncogene

Volume: 25, P: 940-953
Gadd45β is a pro-survival factor associated with stress-resistant tumors

A Engelmann
D Speidel
C Stocking
Research24 Sept 2007
Oncogene

Volume: 27, P: 1429-1438
The putative C-type lectin Schlaff ensures epidermal barrier compactness in Drosophila

Renata Zuber
Khaleelulla Saheb Shaik
Bernard Moussian
ResearchOpen Access29 Mar 2019
Scientific Reports

Volume: 9, P: 1-13
A Delphi consensus statement for digital surgery

Kyle Lam
Michael D. Abràmoff
Sanjay Purkayastha
ResearchOpen Access19 Jul 2022
npj Digital Medicine

Volume: 5, P: 1-9
Surgical data science for next-generation interventions

Interventional healthcare will evolve from an artisanal craft based on the individual experiences, preferences and traditions of physicians into a discipline that relies on objective decision-making on the basis of large-scale data from heterogeneous sources.

Lena Maier-Hein
Swaroop S. Vedula
Pierre Jannin
Comments & Opinion12 Sept 2017
Nature Biomedical Engineering

Volume: 1, P: 691-696
New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53

D Sorriento
C Del Giudice
G Iaccarino
ResearchOpen Access25 Nov 2014
British Journal of Cancer

Volume: 112, P: 77-85
NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways

G Liu
D P Xirodimas
Research25 Jan 2010
Oncogene

Volume: 29, P: 2252-2261
Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation

Kazuhisa Yamamoto
Masayuki Yamato
Hiromi Kojima
ResearchOpen Access24 Mar 2017
npj Regenerative Medicine

Volume: 2, P: 1-11
Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity

Clare E. West
Mohd Karim
Brian D. Marsden
ResearchOpen Access25 Sept 2023
Scientific Data

Volume: 10, P: 1-13
Overnight storage of autologous stem cell apheresis products before cryopreservation does not adversely impact early or long-term engraftment following transplantation

M D Parkins
N Bahlis
D A Stewart
Research18 Sept 2006
Bone Marrow Transplantation

Volume: 38, P: 609-614
Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents

M Michaelis
F Rothweiler
J Cinatl Jr
ResearchOpen Access05 Apr 2012
Cell Death & Disease

Volume: 3, P: e294
c-kit Mutations in Gastrointestinal Stromal Tumors Occur Preferentially in the Spindle Rather Than in the Epithelioid Cell Variant

Eva Wardelmann
Iris Neidt
Torsten Pietsch
Research01 Feb 2002
Modern Pathology

Volume: 15, P: 125-136
Heidelberg colorectal data set for surgical data science in the sensor operating room

Lena Maier-Hein
Martin Wagner
Beat P. Müller-Stich
ResearchOpen Access12 Apr 2021
Scientific Data

Volume: 8, P: 1-11
Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells

M Michaelis
F Rothweiler
J Cinatl jr
ResearchOpen Access15 Dec 2011
Cell Death & Disease

Volume: 2, P: e243
Biological purging of breast cancer cell lines using a replication-competent oncolytic virus in human stem cell autografts

C M Thirukkumaran
J M Luider
D G Morris
Research11 Apr 2005
Bone Marrow Transplantation

Volume: 35, P: 1055-1064

Search

Whole-genome ancestry of an Old Kingdom Egyptian

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

A likelihood-based framework for demographic inference from genealogical trees

Opposite Hand Preferences in Two Sense-modalities

Grey wolf genomic history reveals a dual ancestry of dogs

Recent ultra-rare inherited variants implicate new autism candidate risk genes

The selection landscape and genetic legacy of ancient Eurasians

A disease-associated gene desert directs macrophage inflammation through ETS2

A linkage disequilibrium-based statistical test for Genome-Wide Epistatic Selection Scans in structured populations

Benchtop micro-mashing: high-throughput, robust, experimental beer brewing

Why rankings of biomedical image analysis competitions should be interpreted with care

Continent-wide genomic analysis of the African buffalo (Syncerus caffer)

Uniaxial compression testing and Cauchy stress modeling to design anatomical silicone replicas

Author Correction: Why rankings of biomedical image analysis competitions should be interpreted with care

Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant

Impaired HDL cholesterol efflux in metabolic syndrome is unrelated to glucose tolerance status: the CODAM study

Prognosis and quality of life in patients with locally advanced rectal cancer after abdominoperineal resection in the CAO/ARO/AIO-04 randomized phase 3 trial

Immunogenicity of 2 therapeutic mosaic HIV-1 vaccine strategies in individuals with HIV-1 on antiretroviral therapy

The Dresden in vivo OCT dataset for automatic middle ear segmentation

Early Postnatal Dexamethasone Increases the Risk of Focal Small Bowel Perforation in Extremely Low Birth Weight Infants

Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress

Gadd45β is a pro-survival factor associated with stress-resistant tumors

The putative C-type lectin Schlaff ensures epidermal barrier compactness in Drosophila

A Delphi consensus statement for digital surgery

Surgical data science for next-generation interventions

New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53

NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways

Middle ear mucosal regeneration by tissue-engineered cell sheet transplantation

Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity

Overnight storage of autologous stem cell apheresis products before cryopreservation does not adversely impact early or long-term engraftment following transplantation

Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents

c-kit Mutations in Gastrointestinal Stromal Tumors Occur Preferentially in the Spindle Rather Than in the Epithelioid Cell Variant

Heidelberg colorectal data set for surgical data science in the sensor operating room

Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells

Biological purging of breast cancer cell lines using a replication-competent oncolytic virus in human stem cell autografts

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