Nature Search

Active movement of T cells away from a chemokine

Mark C. Poznansky
Ivona T. Olszak
David T. Scadden
Research01 May 2000
Nature Medicine

Volume: 6, P: 543-548
Cell of origin epigenetic priming determines susceptibility to Tet2 mutation

HSC mutations lead to diverse clonal hematopoiesis outcomes. This study shows how epigenetic traits can predispose clones for dominance. Sox4 increases sensitivity to Tet2 KO, offering insights into variable phenotypes despite identical mutations.

Giulia Schiroli
Vinay Kartha
David T. Scadden
ResearchOpen Access21 May 2024
Nature Communications

Volume: 15, P: 1-20
Distinct bone marrow blood vessels differentially regulate haematopoiesis

Bone marrow endothelial cells have dual roles in the regulation of haematopoietic stem cell maintenance and in the trafficking of blood cells between the bone marrow and the blood circulatory system; this study shows that these different functions are regulated by distinct types of endothelial blood vessels with different permeability properties, affecting the metabolic state of their neighbouring stem cells.

Tomer Itkin
Shiri Gur-Cohen
Tsvee Lapidot
Research13 Apr 2016
Nature

Volume: 532, P: 323-328
System-wide analysis of RNA and protein subcellular localization dynamics

An integrative framework to simultaneously interrogate the dynamics of the transcriptome and proteome at subcellular resolution that combines two methods, localization of RNA (LoRNA) and a streamlined density-based localization of proteins by isotope tagging (dLOPIT).

Eneko Villanueva
Tom Smith
Kathryn S. Lilley
ResearchOpen Access30 Nov 2023
Nature Methods

Volume: 21, P: 60-71
Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells

Toghani, Gupte et al. identify semaphorin 4A as a cell-extrinsic factor that protects myeloid-biased hematopoietic stem cells from inflammaging, mainly produced by their progeny—neutrophils—and acting via a negative feedback loop.

Dorsa Toghani
Sanika Gupte
Lev Silberstein
Research29 Jan 2025
Nature Aging

Volume: 5, P: 558-575
Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML

The role of mTORC1 in AML has not yet been proven due to the mixed results of its inhibitors in clinical trials. Here the authors show the real-time dynamics of the mTORC1 pathway in association with AML growth and response to chemotherapy with fluorescent markers, providing guidance for timed intervention with pathway-specific inhibitors.

Toshihiko Oki
Francois Mercier
David T. Scadden
ResearchOpen Access11 Jan 2021
Nature Communications

Volume: 12, P: 1-13
Author Correction: An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation

Nisarg J. Shah
Angelo S. Mao
David T. Scadden
Amendments and Corrections18 Oct 2021
Nature Biotechnology

Volume: 39, P: 1466
An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation

A bone marrow–like scaffold improves T cell regeneration after hematopoietic stem cell transplantation.

Nisarg J. Shah
Angelo S. Mao
David T. Scadden
Research11 Feb 2019
Nature Biotechnology

Volume: 37, P: 293-302
The bone marrow at the crossroads of blood and immunity

This Review describes the dynamic interactions that occur between haematopoietic stem cells (HSCs), immune cells and their specialized niches in the bone marrow. The authors discuss how the signals provided by the niche help HSCs and immune cells to respond to injury or inflammation in peripheral tissues.

Francois E. Mercier
Christine Ragu
David T. Scadden
Reviews23 Dec 2011
Nature Reviews Immunology

Volume: 12, P: 49-60
Bone marrow adipocytes fuel emergency hematopoiesis after myocardial infarction

Zhang et al. show that bone marrow fatty acid metabolism fuels expanded leukocyte production after myocardial infarction and, based on mouse, pig and human data, suggest that lipolysis in marrow adipocytes provides fatty acids to hematopoietic stem cells.

Shuang Zhang
Alexandre Paccalet
Matthias Nahrendorf
Research05 Dec 2023
Nature Cardiovascular Research

Volume: 2, P: 1277-1290
Generation of human T lymphocytes from bone marrow CD34⁺ cells in vitro

Andrew R. Freedman
Haihong Zhu
David T. Scadden
Research01 Jan 1996
Nature Medicine

Volume: 2, P: 46-51
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis

Nahrendorf and colleagues show that B cells in the bone marrow are an important source of the neurotransmitter acetylcholine, which limits hematopoiesis through modulating the signals produced by the bone marrow stromal niche during steady-state and emergency hematopoiesis.

Maximilian J. Schloss
Maarten Hulsmans
Matthias Nahrendorf
Research28 Mar 2022
Nature Immunology

Volume: 23, P: 605-618
Ribozymes in gene therapy

James D. Thompson
Dennis Macejak
Dan T. Stinchcomb
Advertorial01 Mar 1995
Nature Medicine

Volume: 1, P: 277-278
Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

The beneficial effects of exercise on cardiovascular disease are linked to decreased inflammation through crosstalk between adipose tissue and hematopoietic progenitor cells in the bone marrow.

Vanessa Frodermann
David Rohde
Matthias Nahrendorf
Research07 Nov 2019
Nature Medicine

Volume: 25, P: 1761-1771
C9orf72 suppresses systemic and neural inflammation induced by gut bacteria

Reduced abundance of immune-stimulating gut bacteria ameliorated the inflammatory and autoimmune phenotypes of mice with mutations in C9orf72, which in the human orthologue are linked to amyotrophic lateral sclerosis and frontotemporal dementia.

Aaron Burberry
Michael F. Wells
Kevin Eggan
Research13 May 2020
Nature

Volume: 582, P: 89-94
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease

Sick heart and vessels skew hematopoiesis toward inflammatory myeloid cells. Rhode et al. show that hypertension, atherosclerosis and myocardial infarction cause endothelial dysfunction in bone marrow (BM), which in return causes overproduction of inflammatory myeloid cells and systemic leukocytosis in mice. This process is mediated by VEGF signaling, IL-6 and versican production by the BM endothelium.

David Rohde
Katrien Vandoorne
Matthias Nahrendorf
ResearchOpen Access23 Dec 2021
Nature Cardiovascular Research

Volume: 1, P: 28-44
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness

Thomas, Egan et al. report that hexokinase 2 localizes to the nucleus of leukaemic and normal haematopoietic cells to maintain stemness by interacting with nuclear proteins and modulating chromatin accessibility independently of its kinase activity.

Geethu Emily Thomas
Grace Egan
Aaron D. Schimmer
ResearchOpen Access06 Jun 2022
Nature Cell Biology

Volume: 24, P: 872-884
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

Dorothy A. Sipkins
Xunbin Wei
Charles P. Lin
Research16 Jun 2005
Nature

Volume: 435, P: 969-973
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

Cell-cycle regulation is emerging as a crucial aspect of the ability of stem cells to self-renew. Genetic studies in mice have provided insights into the nature of this regulation, highlighting shared principles in embryonic and adult stem cells.

Keith W. Orford
David T. Scadden
Reviews01 Feb 2008
Nature Reviews Genetics

Volume: 9, P: 115-128
Osteoblastic cells regulate the haematopoietic stem cell niche

L. M. Calvi
G. B. Adams
D. T. Scadden
Research23 Oct 2003
Nature

Volume: 425, P: 841-846
The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

Hematopoietic stem cells (HSCs) migrate from the fetal liver to the bone marrow (BM) during embryogenesis. Here the authors show that the WAVE2 complex scaffold Hem1 is required for engraftment of HSCs in BM, not through its canonical role regulating actin polymerization, but through c-Abl survival signaling.

Lijian Shao
Jianhui Chang
Robert A. Hromas
ResearchOpen Access18 Jun 2018
Nature Communications

Volume: 9, P: 1-12
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis

Maximilian J. Schloss
Maarten Hulsmans
Matthias Nahrendorf
Amendments and Corrections15 Jun 2022
Nature Immunology

Volume: 23, P: 1285
Author Correction: Niche-derived Semaphorin 4A safeguards functional identity of myeloid-biased hematopoietic stem cells

Dorsa Toghani
Sanika Gupte
Lev Silberstein
Amendments and Corrections20 Feb 2025
Nature Aging

Volume: 5, P: 720
Double-stranded RNAs containing multiple IU pairs are sufficient to suppress interferon induction and apoptosis

Adenosine deaminases acting on RNA (ADARs) catalyze hyper-editing of long dsRNAs, converting up to 50% of adenosines to inosine, to form IU-dsRNAs. Now IU-dsRNAs are shown to inhibit activation of IRF3 and suppress induction of interferon-stimulated genes and apoptosis, via specific binding to MDA-5 or RIG-I.

Patrice Vitali
A D J Scadden
Research08 Aug 2010
Nature Structural & Molecular Biology

Volume: 17, P: 1043-1050
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

High-throughput screening systems that better mimic the physiological complexity of diseased tissues may aid the discovery of more efficacious compounds. A co-culture system that mimics the microenvironment of leukemia stem cells (LSCs) in bone marrow enables the discovery of compounds, including lovastatin, that selectively kill LSCs.

Kimberly A Hartwell
Peter G Miller
Todd R Golub
Research27 Oct 2013
Nature Chemical Biology

Volume: 9, P: 840-848
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

The identity of the cells that form the haematopoietic stem cell (HSC) niche in bone marrow has been unclear. These authors identify nestin-expressing mesenchymal stem cells as niche-forming cells. These nestin-expressing cells show a close physical association with HSCs and express high levels of genes involved in HSC maintenance, and their depletion reduces bone marrow homing of haematopoietic progenitors.

Simón Méndez-Ferrer
Tatyana V. Michurina
Paul S. Frenette
Research12 Aug 2010
Nature

Volume: 466, P: 829-834
The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage

A D J Scadden
Research15 May 2005
Nature Structural & Molecular Biology

Volume: 12, P: 489-496
The sense of place in the immune system

Michael D Cahalan
George A Gutman
Special Features01 Apr 2006
Nature Immunology

Volume: 7, P: 329-332
Live-animal imaging of native haematopoietic stem and progenitor cells

A dual genetic strategy enables the labelling and in vivo imaging of native long-term haematopoietic stem cells in the mouse calvarial bone marrow.

Constantina Christodoulou
Joel A. Spencer
Fernando D. Camargo
Research05 Feb 2020
Nature

Volume: 578, P: 278-283
Immune control of HIV-1 after early treatment of acute infection

Eric S. Rosenberg
Marcus Altfeld
Bruce D. Walker
Research28 Sept 2000
Nature

Volume: 407, P: 523-526
IGF-I specifically enhances axon outgrowth of corticospinal motor neurons

P Hande Özdinler
Jeffrey D Macklis
Research22 Oct 2006
Nature Neuroscience

Volume: 9, P: 1371-1381
A simple tool to improve pluripotent stem cell differentiation

Treatment with DMSO improves the differentiation of multiple human pluripotent stem cell lines into cells of all three germ layers.

Sundari Chetty
Felicia Walton Pagliuca
Douglas A Melton
Research14 Apr 2013
Nature Methods

Volume: 10, P: 553-556
Dynamic niches in the origination and differentiation of haematopoietic stem cells

Haematopoietic stem cell function is tightly controlled to maintain haematopoietic homeostasis, in part by specialized cells and factors that constitute the haematopoietic 'niche'. Recent discoveries have engendered a new appreciation for the dynamic nature of the niche, identifying novel cellular and acellular niche components and uncovering fluctuations in their importance over time.

Leo D. Wang
Amy J. Wagers
Reviews02 Sept 2011
Nature Reviews Molecular Cell Biology

Volume: 12, P: 643-655
Phase I study of accelerated FEC with granulocyte colony-stimulating factor (Lenograstim) support

D Bissett
D Jodrell
PA Canney
Research01 Jun 1995
British Journal of Cancer

Volume: 71, P: 1279-1282
High levels of circulating CD34+ cells at autologous stem cell collection are associated with favourable prognosis in multiple myeloma

J Raschle
D Ratschiller
T Pabst
ResearchOpen Access30 Aug 2011
British Journal of Cancer

Volume: 105, P: 970-974
FLT3 signaling in hematopoietic cells involves CBL, SHC and an unknown P115 as prominent tyrosine-phosphorylated substrates

C Lavagna-Sévenier
S Marchetto
O Rosnet
Research30 Apr 1998
Leukemia

Volume: 12, P: 301-310
Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube

Andrew D Bergemann
Lee Zhang
John G Flanagan
Research03 Feb 1998
Oncogene

Volume: 16, P: 471-480
Constitutive cytokine production by primary effusion (body cavity-based) lymphoma-derived cell lines

HG Drexler
C Meyer
A Carbone
Research16 Apr 1999
Leukemia

Volume: 13, P: 634-640
Selection of BCR/ABL-negative stem cells from marrow or blood of patients with chronic myeloid leukemia

D Guyotat
K Wahbi
L Campos
Research22 Jul 1999
Leukemia

Volume: 13, P: 991-998
CHIP/Stub1 regulates the Warburg effect by promoting degradation of PKM2 in ovarian carcinoma

Y Shang
J He
Z Chang
Research27 Mar 2017
Oncogene

Volume: 36, P: 4191-4200
Silencing p21^{Waf1/Cip1/Sdi1} expression increases gene transduction efficiency in primitive human hematopoietic cells

J Zhang
E Attar
D Scadden
Research05 May 2005
Gene Therapy

Volume: 12, P: 1444-1452
Detection of functional haematopoietic stem cell niche using real-time imaging

Recently haematopoietic stem cell niches have been shown to comprise osteoblastic and vascular microenvironments. This study describes a newly developed ex vivo real-time imaging technology and immunoassaying to trace the homing of highly purified GFP-expressing haematopoietic stem cells in response to irradiation.

Yucai Xie
Tong Yin
Linheng Li
Research03 Dec 2008
Nature

Volume: 457, P: 97-101
Chinese scientists and US leadership in the life sciences

Steven H. Holtzman
Ron Cohen
Shuguang Zhang
Correspondence03 Oct 2019
Nature Biotechnology

Volume: 37, P: 1261-1263
A niche opportunity for stem cell therapeutics

G B Adams
D T Scadden
Reviews15 Nov 2007
Gene Therapy

Volume: 15, P: 96-99
Biotech leaders call for free press

Ron Cohen
Steven Holtzman
Sanford Sandy Zweifach
Correspondence01 Oct 2018
Nature Biotechnology

Volume: 36, P: 920-922
In vitro and in vivo expansion of hematopoietic stem cells

Guy Sauvageau
Norman N Iscove
R Keith Humphries
Reviews20 Sept 2004
Oncogene

Volume: 23, P: 7223-7232
Preclinical activity of P276-00, a novel small-molecule cyclin-dependent kinase inhibitor in the therapy of multiple myeloma

N Raje
T Hideshima
K C Anderson
Research08 Jan 2009
Leukemia

Volume: 23, P: 961-970
Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch signaling in chronic myeloid leukemia progression

A Sengupta
D Banerjee
S Banerjee
Research15 Mar 2007
Leukemia

Volume: 21, P: 949-955
A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

S Vallet
S Pozzi
N Raje
Research15 Mar 2011
Leukemia

Volume: 25, P: 1174-1181
Regulation of hematopoietic stem cell growth

E C Attar
D T Scadden
Reviews30 Sept 2004
Leukemia

Volume: 18, P: 1760-1768

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