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Showing 251–300 of 2551 results

Advanced filters: Author: D Takahashi Clear advanced filters

COMPASS: joint copy number and mutation phylogeny reconstruction from amplicon single-cell sequencing data

Understanding the evolution of a tumor is important for predicting its resistance to treatment. This paper presents a new computational method, COMPASS, for inferring the joint phylogeny of single nucleotide variants and copy number alterations from targeted scDNAseq data.

Etienne Sollier
Jack Kuipers
Katharina Jahn
ResearchOpen Access15 Aug 2023
Nature Communications

Volume: 14, P: 1-13
Decryption of sequence, structure, and functional features of SINE repeat elements in SINEUP non-coding RNA-mediated post-transcriptional gene regulation

Here the authors elucidate structure-function relationships of SINEUPs, antisense long non-coding RNAs that through SINE repeat elements positively regulate protein translation of mRNAs they pair with. SINEUP’s functional domains do not share common ancestors.

Harshita Sharma
Matthew N. Z. Valentine
Piero Carninci
ResearchOpen Access21 Feb 2024
Nature Communications

Volume: 15, P: 1-19
Isolation of a Glycoprotein Fraction from Human Platelet Membranes which inhibits Viral Haemagglutination

D. S. PEPPER
G. A. JAMIESON
Research21 Sept 1968
Nature

Volume: 219, P: 1252-1253
Phosphorus limitation of net production in a confined aquatic ecosystem

S. V. Smith
M. J. Atkinson
Research16 Feb 1984
Nature

Volume: 307, P: 626-627
Effect of Enzymes on Mechanical Properties of Tissues

MARGARET L. R. HARKNESS
R. D. HARKNESS
Research27 Jun 1959
Nature

Volume: 183, P: 1821-1822
Galactic chronology of thorium/neodymium

PETER D. NOERDLINGER
Research31 Dec 1987
Nature

Volume: 330, P: 704
Quantification of liver steatosis of metabolic dysfunction-associated steatotic liver disease based on body composition analysis

Toshikazu Kohira
Satoshi Oeda
Hirokazu Takahashi
ResearchOpen Access30 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes

An integrated analysis of de novo and inherited coding variants in 42,607 individuals with autism spectrum disorder identifies 60 risk genes of which five have not previously been associated with neurodevelopmental disorders.

Xueya Zhou
Pamela Feliciano
Wendy K. Chung
ResearchOpen Access18 Aug 2022
Nature Genetics

Volume: 54, P: 1305-1319
Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics

Masayoshi Tachibana
Kazuhisa Takeda
Toru Miki
Research01 Sept 1996
Nature Genetics

Volume: 14, P: 50-54
Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy

B. Böttcher
S. A. Wynne
R. A. Crowther
Research06 Mar 1997
Nature

Volume: 386, P: 88-91
The unique allosteric property of crocodilian haemoglobin elucidated by cryo-EM

Crocodilians are ambush predators that possess haemoglobin with an allosteric switch between R (high oxygen affinity) and T (low oxygen affinity) forms strongly controlled by bicarbonate ions, a unique evolutionary feature that helps the animal to stay underwater for extended periods of time.

Katsuya Takahashi
Yongchan Lee
Jeremy R. H. Tame
ResearchOpen Access02 Aug 2024
Nature Communications

Volume: 15, P: 1-10
Conformational transitions in oriented fibres of the synthetic polynucleotide poly[d(AT)]·poly[d(AT)] double helix

A. Mahendrasingam
N. J. Rhodes
J. Vergne
Research10 Feb 1983
Nature

Volume: 301, P: 535-537
Altered imprinting in lung cancer

Hiroko Suzuki
Ryuzo Ueda
Takashi Takahashi
Correspondence01 Apr 1994
Nature Genetics

Volume: 6, P: 332-333
Atomic model of plant light-harvesting complex by electron crystallography

Werner Kühlbrandt
Da Neng Wang
Yoshinori Fujiyoshi
Research17 Feb 1994
Nature

Volume: 367, P: 614-621
The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit

Circadian activity modulation in the suprachiasmatic nucleus (SCN) is a network-level emergent property that requires neuropeptide VIP signaling, yet the precise cellular mechanisms are unknown. Patton et al. show that cells expressing VIP or its receptor VPAC2 together determine these emergent properties of the SCN.

Andrew P. Patton
Mathew D. Edwards
Michael H. Hastings
ResearchOpen Access07 Jul 2020
Nature Communications

Volume: 11, P: 1-17
A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules

Brunella Franco
Silvana Guioli
Andrea Ballabio
Research10 Oct 1991
Nature

Volume: 353, P: 529-536
Increase of Evaporative Loss of Water from the Skin of the Ox in Response to Local Heating of the Hypothalamus

D. L. INGRAM
J. A. McLEAN
G. C. WHITTOW
Research01 Jul 1961
Nature

Volume: 191, P: 81-82
Labelling of Phospholipids with Phosphorus-32 in Rat Liver Homogenates

F. D. COLLINS
Research17 Nov 1962
Nature

Volume: 196, P: 671-672
Biological Activity of Natural and Synthetic Insulin A-chain Preparations on the Isolated Rat Diaphragm

P. VOLFIN
M. CHAMBAUT
H. ZAHN
Research25 Jul 1964
Nature

Volume: 203, P: 408-409
Mechanism of Abdominal Extension during Oviposition in Locusta

J. F. V. VINCENT
SONYA D. E. WOOD
Research21 Jan 1972
Nature

Volume: 235, P: 167-168
IgG Subclass Specificity of Human Monocyte Receptor Sites

H. HUBER
S. D. DOUGLAS
R. E. ROSENFIELD
Research05 Feb 1971
Nature

Volume: 229, P: 419-420
Specialized Connexions between Nerve Cells and Mesenchymal Cells in Ctenophores

MARI-LUZ HERNANDEZ-NICAISE
Research16 Mar 1968
Nature

Volume: 217, P: 1075-1076
Carbon-14 Labelled Photosynthate in Wheat Root Exudates

BARBARA M. McDOUGALL
A. D. ROVIRA
Research01 Sept 1965
Nature

Volume: 207, P: 1104-1105
Effect of an Exogenous Interferon on Experimental Influenza Virus Infection and Interferon Production in White Mice

F. LINK
D. BLAŠKOVIČ
J. RAUS
Research23 Feb 1963
Nature

Volume: 197, P: 821-822
Repairing quadrature entanglement

Optical loss degrades quantum correlations, hindering the use of quantum quadrature entanglement for many applications. Researchers have now experimentally demonstrated that this entanglement can be recovered using photon subtraction.

Alexei Ourjoumtsev
News & Views01 Mar 2010
Nature Photonics

Volume: 4, P: 136-138
NMR-guided directed evolution

NMR spectroscopy has been used to guide the directed evolution of myoglobin to a Kemp eliminase with high catalytic efficiency, outlining an approach that is likely to be generally applicable to other enzyme activities.

Sagar Bhattacharya
Eleonora G. Margheritis
Ivan V. Korendovych
Research05 Oct 2022
Nature

Volume: 610, P: 389-393
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

J. M. Adams
A. W. Harris
R. L. Brinster
Research01 Dec 1985
Nature

Volume: 318, P: 533-538
Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers

Human endogenous retroviruses (HERV) normally remain quiescent, but can be reactivated by malignant transformation. Here the authors find, via HERV peptide library testing and tetramer validation, more profound HERV transcription and associated T cell recognition in myeloid cancer patients to implicate HERVs as potential therapeutic targets.

Sunil Kumar Saini
Andreas Due Ørskov
Sine Reker Hadrup
ResearchOpen Access09 Nov 2020
Nature Communications

Volume: 11, P: 1-14
Sudden changes in North Atlantic circulation during the last deglaciation

Scott J. Lehman
Lloyd D. Keigwin
Research30 Apr 1992
Nature

Volume: 356, P: 757-762
Evidence for deep mantle circulation from global tomography

R. D. van der Hilst
S. Widiyantoro
E. R. Engdahl
Research10 Apr 1997
Nature

Volume: 386, P: 578-584
Organic synthesis in the atmosphere of Titan

S. Gupta
E. Ochiai
C. Ponnamperuma
Research29 Oct 1981
Nature

Volume: 293, P: 725-727
Melting history of Antarctica during the past 60,000 years

L. D. Labeyrie
J. J. Pichon
J. C. Duplessy
Research21 Aug 1986
Nature

Volume: 322, P: 701-706
The contribution of water radiolysis to marine sedimentary life

The extent to which chemical products of water radiolysis could sustain subseafloor microbial life is unknown. Here the authors show that sediment catalyzes radiolytic production of H₂ and oxidants, providing the primary energy source for life in ancient marine sediment.

Justine F. Sauvage
Ashton Flinders
Steven D’Hondt
ResearchOpen Access26 Feb 2021
Nature Communications

Volume: 12, P: 1-9
Host-derived protein profiles of human neonatal meconium across gestational ages

Meconium, a non-invasive biomaterial reflecting prenatal substance accumulation, holds promise for offering valuable insights into neonatal health. Here, the authors perform an extensive proteomic analysis of meconium samples collected from 259 newborns spanning various gestational ages.

Yoshihiko Shitara
Ryo Konno
Eiichiro Watanabe
ResearchOpen Access17 Jul 2024
Nature Communications

Volume: 15, P: 1-13
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor

Wilma Wasco
Sarada Gurubhagavatula
Rudolph E. Tanzi
Research01 Sept 1993
Nature Genetics

Volume: 5, P: 95-100
No UVB effect?

M. L. Bothwell
D. Karentz
E. J. Carpenter
Research13 Apr 1995
Nature

Volume: 374, P: 601
Dopamine Excretion in Affective States and following Li₂CO₃ Therapy

F. S. MESSIHA
D. AGALLIANOS
C. CLOWER
Research28 Feb 1970
Nature

Volume: 225, P: 868-869
Uniquely Labelled Active Site Sequence in Chicken Muscle Triose Phosphate Isomerase

A. F. W. COULSON
J. R. KNOWLES
R. E. OFFORD
Research11 Jul 1970
Nature

Volume: 227, P: 180-181
Melatonin in Peripheral Nerve

AARON B. LERNER
JAMES D. CASE
MARGARET R. WRIGHT
Research27 Jun 1959
Nature

Volume: 183, P: 1821
Lack of Growth-promoting Activity of Inactivated Penicillin with Turkey Poults

J. R. JOWSEY
F. D. COOK
R. M. BLAKELY
Research02 Nov 1957
Nature

Volume: 180, P: 923
Effect of Previous Stress-Strain History on the Dynamic Hysteresis Loop for Rubber in Compression

D. M. DAVIES
H. McCALLION
Research06 Feb 1954
Nature

Volume: 173, P: 262-263
PET imaging of brain aromatase in humans and rhesus monkeys by ¹¹C-labeled cetrozole analogs

Kayo Takahashi
Takamitsu Hosoya
Yasuyoshi Watanabe
ResearchOpen Access08 Dec 2021
Scientific Reports

Volume: 11, P: 1-9
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation

Ubiquitylation of histone H3 (H3Ub2) by UHRF1 recruits DNMT1 to chromatin, which is essential for DNA methylation inheritance. Here, the authors provide evidence that there are two distinct mechanisms underlying replication timing-dependent recruitment of DNMT1 through PAF15Ub2 and H3Ub2, both of which are required for high fidelity DNA methylation inheritance.

Atsuya Nishiyama
Christopher B. Mulholland
Makoto Nakanishi
ResearchOpen Access06 Mar 2020
Nature Communications

Volume: 11, P: 1-17
Glacial-to-interglacial variations in the carbon isotopic composition of atmospheric CO₂

Bruno D. Marino
Michael B. McElroy
W. Geoffrey Spaulding
Research11 Jun 1992
Nature

Volume: 357, P: 461-466
Monoclonal antibody against the fusion junction of a deletion-mutant epidermal growth factor receptor

S Okamoto
K Yoshikawa
T Takahashi
Research01 Jun 1996
British Journal of Cancer

Volume: 73, P: 1366-1372
Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards

Here, the authors compared measurements between 34 laboratories from 19 countries, to quantify by mass spectrometry four ceramides of clinical relevance in human blood plasma Standard Reference Materials. The main goals were to evaluate concordance obtained in a large inter-laboratory trial and to report absolute concentrations of four circulating lipids in a publicly available standard.

Federico Torta
Nils Hoffmann
Markus R. Wenk
ResearchOpen Access03 Oct 2024
Nature Communications

Volume: 15, P: 1-15
Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

Jhumku D. Kohtz
Sharon F. Jamison
James L. Manley
Research10 Mar 1994
Nature

Volume: 368, P: 119-124
A 150,000-year climatic record from Antarctic ice

C. Lorius
J. Jouzel
V. M. Kotlyakov
Research01 Aug 1985
Nature

Volume: 316, P: 591-596
An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF^Cdc4 ubiquitin ligase

The WD40 domain of the SCF^Cdc4ubiquitin ligase targets substrates via multiple phosphorylated degron motifs. The authors define a second degron-binding WD40 pocket that imparts a negative allosteric effect on binding to the primary pocket, and thereby enables the dynamic exchange of bound degrons.

Veronika Csizmok
Stephen Orlicky
Julie D. Forman-Kay
ResearchOpen Access03 Jan 2017
Nature Communications

Volume: 8, P: 1-14
Cabozantinib and nivolumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial

In a randomized phase 1 trial, the addition of a live Clostridium species-containing product to a tyrosine kinase inhibitor and anti-programmed cell death protein 1 treatment combination did not increase bacterial abundance of Bifidobacterium spp. but enhanced clinical responses in participants with metastatic renal cell carcinoma.

Hedyeh Ebrahimi
Nazli Dizman
Sumanta K. Pal
ResearchOpen Access28 Jun 2024
Nature Medicine

Volume: 30, P: 2576-2585

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