In this paper, the authors dissected the temporal sequence of three early events in diabetic retinopathy. They show that vascular degeneration is the initiating cellular change during the development of retinopathy in the diabetic Nile rat. Focusing on vascular events, they conducted a detailed longitudinal study and showed that the Nile rat exhibits a wide range of retinal lesions remarkably similar to the human condition.
- Huishi Toh
- Alexander Smolentsev
- James A. Thomson
