Nature Search

The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor

Martin Steegmaler
Agneta Levinovitz
Dletmar Vestweber
Research16 Feb 1995
Nature

Volume: 373, P: 615-620
P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflamed tissues

Frank Austrup
Dietmar Vestweber
Alf Hamann
Research02 Jan 1997
Nature

Volume: 385, P: 81-83
A yeast mitochondrial outer membrane protein essential for protein import and cell viability

Kevin P. Baker
Angela Schaniel
Gottfried Schatz
Research13 Dec 1990
Nature

Volume: 348, P: 605-609
A protein of the endoplasmic reticulum involved early in polypeptide translocation

Dirk Görlich
Enno Hartmann
Tom A. Rapoport
Research07 May 1992
Nature

Volume: 357, P: 47-52
Binding Sites for Lewis Antigens Are Expressed by Human Colon Cancer Cells and Negatively Affect Their Migration

Axel Hittelet
Isabelle Camby
Paul Yeaton
Research01 Jun 2003
Laboratory Investigation

Volume: 83, P: 777-787
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

Pipsa Saharinen
Lauri Eklund
Kari Alitalo
Research20 Apr 2008
Nature Cell Biology

Volume: 10, P: 527-537
Proximity interactome of lymphatic VE-cadherin reveals mechanisms of junctional remodeling and reelin secretion

VE-cadherin is a cell adhesion and signaling molecule that regulates lymphatic cell behaviors. Here the authors show how the VE-cadherin interactome changes in response to junctional remodeling by adrenomedullin and identify mechanisms of VE-cadherin recycling and reelin secretion.

D. Stephen Serafin
Natalie R. Harris
Kathleen M. Caron
ResearchOpen Access04 Sept 2024
Nature Communications

Volume: 15, P: 1-18
Syndecan-2 selectively regulates VEGF-induced vascular permeability

Corti et al. show that the proteoglycan Syndecan-2 (Sdc2) regulates the interaction between phosphatase DEP1 and the vascular endothelial growth factor receptor VEGFR2. Depletion or antibody-mediated inhibition of Sdc2 causes compromised internalization of DEP1, and excessive expression of DEP1 in the membrane results in large dephosphorylation specifically of VEGFR2 Y951 residue, leading to reduced VEGF-mediated permeabilization without affecting other VEGF-mediated functions, with beneficial effects in animal models of skin edema and brain focal stroke.

F. Corti
E. Ristori
M. Simons
Research16 May 2022
Nature Cardiovascular Research

Volume: 1, P: 518-528
Spatial regulation of VEGF receptor endocytosis in angiogenesis

The sprouting activity of filopodia emerging from endothelial sprouting cells needs to be compensated for in mature stable vessels. Adams and colleagues find that sprouting cells in mouse retinal vasculature show high VEGF uptake and VEGF receptor turnover, both essential for sprouting. These are inhibited by an aPKC-mediated decrease in VEGF receptor endocytosis in mature vessels, through a mechanism implicating clathrin-associated proteins, the transmembrane protein ephrin-B2 and the polarity factor PAR-3.

Masanori Nakayama
Akiko Nakayama
Ralf H. Adams
Research27 Jan 2013
Nature Cell Biology

Volume: 15, P: 249-260
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice

A combination of single-cell approaches, lineage tracing and metabolomics is used to characterize the changes to intestinal stem cell function in the small intestine that underlie intestinal maladaptation in mice fed an obesogenic diet.

Alexandra Aliluev
Sophie Tritschler
Anika Böttcher
ResearchOpen Access22 Sept 2021
Nature Metabolism

Volume: 3, P: 1202-1216
Endomucin prevents leukocyte–endothelial cell adhesion and has a critical role under resting and inflammatory conditions

Endomucin is expressed by endothelial cells that line postcapillary venules—the site of leukocyte recruitment during inflammation. Zahr et al.show that endomucin is an anti-adhesive molecule that is downregulated by the cytokine TNF-a and thereby helps in the transition from a quiescent to a pro-adhesive inflamed endothelium.

Alisar Zahr
Pilar Alcaide
Pablo Argüeso
ResearchOpen Access02 Feb 2016
Nature Communications

Volume: 7, P: 1-10
Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium

Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous remodelling of cellular overlaps that maintain vessel integrity.

Hans Schoofs
Nina Daubel
Taija Mäkinen
ResearchOpen Access19 Mar 2025
Nature

Volume: 641, P: 465-475
Glycolytic regulation of cell rearrangement in angiogenesis

Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing intercellular adhesion, and empirically validate this prediction.

Bert Cruys
Brian W. Wong
Peter Carmeliet
ResearchOpen Access20 Jul 2016
Nature Communications

Volume: 7, P: 1-15
Delayed recombination as a major source of the soft X-ray background

D. Breitschwerdt
T. Schmutzler
Research27 Oct 1994
Nature

Volume: 371, P: 774-777
Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation

Miles A. Whittington
Roger D. Traub
John G. R. Jefferys
Research16 Feb 1995
Nature

Volume: 373, P: 612-615
Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids

Robert W. Taylor
Patrick F. Chinnery
Robert N. Lightowlers
Research01 Feb 1997
Nature Genetics

Volume: 15, P: 212-215
Role of morphogenetic factors in metastasis of mammary carcinoma cells

Silke Meiners
Volker Brinkmann
Walter Birchmeier
Research21 Jan 1998
Oncogene

Volume: 16, P: 9-20
Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

Humphries and colleagues analyse proteomic data of integrin adhesion complexes to derive a consensus integrin adhesome and characterize the temporal dynamics of adhesome component recruitment during adhesion complex assembly and disassembly.

Edward R. Horton
Adam Byron
Martin J. Humphries
Research19 Oct 2015
Nature Cell Biology

Volume: 17, P: 1577-1587
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling

DLL4–Notch signalling suppresses endothelial sprouting and angiogenic growth through crosstalk with the vascular endothelial growth factor (VEGF) pathway; VEGF receptor 2 has been thought to have a crucial role in this crosstalk, but now VEGF receptor 3 is shown to be the more important modulator.

Rui Benedito
Susana F. Rocha
Ralf H. Adams
Research18 Mar 2012
Nature

Volume: 484, P: 110-114
AKAP12 regulates vascular integrity in zebrafish

Hyouk-Bum Kwon
Yoon Kyung Choi
Kyu-Won Kim
ResearchOpen Access22 Dec 2011
Experimental & Molecular Medicine

Volume: 44, P: 225-235
Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis

Jin and coauthors show that Yes-mediated tyrosine phosphorylation is critical for VE-cadherin’s constitutive internalization and junctional pliability in endothelial cells, but it is not required for the induction of vascular leakage.

Yi Jin
Yindi Ding
Lena Claesson-Welsh
ResearchOpen Access07 Dec 2022
Nature Cardiovascular Research

Volume: 1, P: 1156-1173
Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature

Sheikh et al. show that deficiency in the lysine acetyltransferase MOF causes aberrant accumulation of fatty acids in neural cells, which in turn triggers inflammation in nearby pericytes, resulting in brain haemorrhaging.

Bilal N. Sheikh
Sukanya Guhathakurta
Asifa Akhtar
Research15 Jun 2020
Nature Cell Biology

Volume: 22, P: 828-841
Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice

Yizhi Jiang
Yaqiong Tang
Lijun Xia
ResearchOpen Access15 May 2021
Cell Death & Differentiation

Volume: 28, P: 3009-3021
Integrin β1 controls VE-cadherin localization and blood vessel stability

The role of integrin β1 in angiogenesis is poorly understood. Here, the authors show that integrin β1 regulates murine angiogenesis and adherens junction integrity by controlling VE-cadherin localization, myosin light chain phosphorylation and the function of the Rap1/MRCK and Rho/Rho-kinase pathways.

Hiroyuki Yamamoto
Manuel Ehling
Ralf H. Adams
Research10 Mar 2015
Nature Communications

Volume: 6, P: 1-14
A new player in lymphocyte homing

The homing of lymphocytes to secondary lymphoid organs occurs at specialized blood vessels, the high endothelial venules. Autotaxin, a phospholipid-producing enzyme secreted by high endothelial venule endothelium, is a new participant found to facilitate the entry of lymphocytes into secondary lymphoid organs.

Dietmar Vestweber
Martin K Wild
News & Views01 Apr 2008
Nature Immunology

Volume: 9, P: 347-348
An evolutionary history of the selectin gene cluster in humans

M Fumagalli
M Fracassetti
M Sironi
Research02 May 2012
Heredity

Volume: 109, P: 117-126
Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours

C Scotton
D Milliken
F Balkwill
ResearchOpen Access11 Sept 2001
British Journal of Cancer

Volume: 85, P: 891-897
Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling

Cindy Park-Windhol
Yin Shan Ng
Patricia A. D’Amore
ResearchOpen Access07 Dec 2017
Scientific Reports

Volume: 7, P: 1-13
Peptide nucleic acid delivery to human mitochondria

P F Chinnery
R W Taylor
R N Lightowlers
Research05 Jan 2000
Gene Therapy

Volume: 6, P: 1919-1928
How leukocytes cross the vascular endothelium

Reciprocal interactions between leukocytes and endothelial cells enable leukocytes to recognize the blood vessel endothelium in areas of inflammation and transmigrate across the endothelial barrier to mount an immune response in infected and/or damaged tissues.

Dietmar Vestweber
Reviews16 Oct 2015
Nature Reviews Immunology

Volume: 15, P: 692-704
An agonistic anti-Tie2 antibody suppresses the normal-to-tumor vascular transition in the glioblastoma invasion zone

Eunhyeong Lee
Eun-Ah Lee
Injune Kim
ResearchOpen Access24 Feb 2023
Experimental & Molecular Medicine

Volume: 55, P: 470-484
Regulation of transendothelial migration of colon cancer cells by E-selectin-mediated activation of p38 and ERK MAP kinases

P-L Tremblay
F A Auger
J Huot
Research22 May 2006
Oncogene

Volume: 25, P: 6563-6573
CD3 directed bispecific antibodies induce increased lymphocyte–endothelial cell interactions in vitro

G Molema
J W Cohen Tervaert
L F M H de Leij
ResearchOpen Access17 Dec 1999
British Journal of Cancer

Volume: 82, P: 472-479
In vivo evaluation of the early events associated with liver metastasis of circulating cancer cells

L Ding
M Sunamura
S Matsuno
ResearchOpen Access31 Jul 2001
British Journal of Cancer

Volume: 85, P: 431-438
Identification of genes involved in VEGF-mediated vascular morphogenesis using embryonic stem cell-derived cystic embryoid bodies

Yin-Shan Ng
Markus Ramsauer
Patricia A D'Amore
Research28 Jun 2004
Laboratory Investigation

Volume: 84, P: 1209-1218
Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin secretion and actomyosin contractility

Alexander García Ponce
Alí F. Citalán Madrid
Michael Schnoor
ResearchOpen Access30 Jun 2016
Scientific Reports

Volume: 6, P: 1-13
The impact of the extracellular matrix on inflammation

The extracellular matrix (ECM) has crucial, though often overlooked, roles during the development of an inflammatory response. Lydia Sorokin describes the interactions that occur between leukocytes and the ECM and discusses how aberrant regulation of ECM components may promote chronic inflammation.

Lydia Sorokin
Reviews24 Sept 2010
Nature Reviews Immunology

Volume: 10, P: 712-723
Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease

G Jurisic
J P Sundberg
M Detmar
Research11 Mar 2010
Genes & Immunity

Volume: 11, P: 219-231
Apoptosis induced by disruption of the actin cytoskeleton is mediated via activation of CD95 (Fas/APO-1)

D Kulms
H Düßmann
T Schwarz
Research24 May 2002
Cell Death & Differentiation

Volume: 9, P: 598-608

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