The authors review the fundamental roles of N6-methyl-adenine in bacteria. In γ-proteobacteria, Dam methylation facilitates DNA–protein interactions involved in chromosome segregation, mismatch repair, transposition, and the epigenetic control of gene expression. In α-proteobacteria, the CcrM methylase is an important cell-cycle regulator.
- Didier Wion
- Josep Casadesús
