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Showing 1–2 of 2 results
Advanced filters: Author: D. Krokowski Clear advanced filters

  • A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 axis, enabling metabolic reprogramming.

    • Chien-Wen Chen
    • David Papadopoli
    • Maria Hatzoglou
    ResearchOpen Access
    Nature
    Volume: 641, P: 1319-1328

  • Blumental-Perry et al. find that exposure to cigarette smoke causes the redistribution of the mitochondria-encoded non-codling RNA, mito-ncR-805, from mitochondria to the nucleus in alveolar epithelial cells. This relocation event correlates with increased expression of nuclear genes involved in mitochondrial function, suggesting that this response has a protective role.

    • A. Blumental-Perry
    • R. Jobava
    • M. Hatzoglou
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-17