Nature Search

Nature of the Scrapie Agent: Self-replication and Scrapie

J. S. GRIFFITH
Research02 Sept 1967
Nature

Volume: 215, P: 1043-1044
Nature of the Scrapie Agent

R. A. GIBBONS
G. D. HUNTER
Research02 Sept 1967
Nature

Volume: 215, P: 1041-1043
Evidence for differential intracellular localization of the Acanthamoeba myosin isoenzymes

Hana Gadasi
Edward D. Korn
Research31 Jul 1980
Nature

Volume: 286, P: 452-456
Genetic modifiers of APOE-ε4-associated cognitive decline

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Alex G. Contreras
Skylar Walters
Timothy J. Hohman
ResearchOpen Access20 Feb 2026
Nature Communications

P: 1-17
Discovery of NIRF theranostic probes targeting amyloid-β and cholinesterases in Alzheimer’s disease models

This study reports NIR probes targeting amyloid-β aggregates and cholinesterases for dual diagnostics and therapy. Lead probe I-43 detects Aβ in APP-PS1 mice, improves memory in a scopolamine model, and offers a template for future probe development.

Himanshu Rai
Rishabh Singh
Gyan Modi
ResearchOpen Access26 Jan 2026
Nature Communications

Volume: 17, P: 1-26
Further Studies of Electron Transport Components in a Series of Morris Hepatoma-Bearing Rats

S K Chattopadhyay
H D Brown
H P Morris
Research01 Feb 1972
British Journal of Cancer

Volume: 26, P: 3-5
Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases

Genome-wide association analyses using data from 19 biobanks identify variants influencing risk of thyroid diseases and yield polygenic risk scores associated with features of aggressive thyroid cancer.

Samantha L. White
Maizy S. Brasher
Nikita Pozdeyev
ResearchOpen Access05 Feb 2026
Nature Genetics

Volume: 58, P: 307-316
Neuronal type-specific modulation of cognition and AP-1 signaling by early-life rearing conditions

Early experiences shape cognition. Here, authors show that early environmental enrichment or deprivation alters cognition in mice, linked to gene expression and chromatin changes in hippocampal excitatory neurons, with AP-1 as a key regulator.

Marta Alaiz-Noya
Federico Miozzo
Angel Barco
ResearchOpen Access05 Nov 2025
Nature Communications

Volume: 16, P: 1-21
A Preliminary Report on the Thymidine Labeling Indices and Kinetics of Cell Proliferation in Selected Morris Hepatomas

W B Looney
A A Mayo
H P Morris
Research01 Dec 1970
British Journal of Cancer

Volume: 24, P: 826-832
Ecological control on micro-ornamentation of conodont elements

Andrey Zhuravlev Dr.
ResearchOpen Access09 Aug 2007
Nature Precedings

P: 1
Extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents

In a study of four brain-dead human decedents, extracorporeal liver cross-circulation using genetically modified pig livers provides essential hepatic functions, supporting the feasibility of this approach for temporary liver support as a bridge to organ transplantation.

Abraham Shaked
Alex Sagar
Peter Friend
Research09 Feb 2026
Nature Medicine

P: 1-11
Natural and inducible T_H17 cells are regulated differently by Akt and mTOR pathways

The Akt-mTOR axis influences cell activation, differentiation and metabolism. Jordan and colleagues show that thymic and inducible T_H17 cells exhibit different requirements for mTORC1 and mTORC2 as well as Akt isoforms.

Jiyeon S Kim
Tammarah Sklarz
Gary A Koretzky
Research05 May 2013
Nature Immunology

Volume: 14, P: 611-618
Pathogenic variants in SMARCA1 cause an X-linked neurodevelopmental disorder modulated by NURF complex composition

The authors identify pathogenic variants in the SMARCA1 gene as the cause of a variable neurodevelopmental disorder. Mouse studies suggest diverse genetic mechanisms related to NURF complex composition mediate the phenotype.

Ghayda M. Mirzaa
Keqin Yan
David J. Picketts
ResearchOpen Access10 Nov 2025
Nature Communications

Volume: 16, P: 1-21
Author Correction: Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire

Brian D. Stadinski
Elizabeth A. Mills
Wan-Lin Lo
Amendments and CorrectionsOpen Access19 Feb 2026
Nature Immunology

P: 1
Potent and dose-sparing next-generation SARS-CoV-2 vaccine, mRNA-1283, induces polyfunctional and durable T cell immunity

Yamuna D. Paila
Rolando Pajon
Robert Paris
ResearchOpen Access19 Feb 2026
npj Vaccines

P: 1-15
Predicting multiphase flow and tracer transport for an underground chemical explosive test

John P. Ortiz
Dolan D. Lucero
Cleat Zeiler
ResearchOpen Access17 Feb 2026
Scientific Reports

P: 1-13
Annual Rhythm of Wool Growth

J. W. BENNETT
J. C. D. HUTCHINSON
MANIKA WODZICKA-TOMASZEWSKA
Research19 May 1962
Nature

Volume: 194, P: 651-652
APOE4 to APOE2 allelic switching in mice improves Alzheimer’s disease-related metabolic signatures, neuropathology and cognition

Using a mouse model enabling an inducible ‘switch’, Golden et al. show that an astrocyte-specific replacement of the Alzheimer’s risk gene APOE4 with protective APOE2 alters metabolism and gene expression, reducing amyloid pathology and gliosis.

Lesley R. Golden
Dahlia S. Siano
Lance A. Johnson
ResearchOpen Access11 Nov 2025
Nature Neuroscience

Volume: 28, P: 2461-2475
Interstellar extinction in the Large Magellanic Cloud

K. Nandy
D. H. Morgan
L. Houziaux
Research21 Feb 1980
Nature

Volume: 283, P: 725-729
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
A framework for integrating genomics, microbial traits, and ecosystem biogeochemistry

Microbes drive the Earth’s biogeochemical cycles. Here, Li et al. present a framework for integrating genome-inferred microbial kinetic traits into ecosystem mechanistic models, and use it to benchmark predictions against observed greenhouse gas emissions at an Arctic wetland.

Zhen Li
William J. Riley
Eoin L. Brodie
ResearchOpen Access04 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Full-spectrum extract from Cannabis sativa DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial

A phase 3 trial found that VER-01, a full-spectrum cannabis extract, reduces chronic low back pain, improves physical function and sleep and shows no signs of dependence or withdrawal.

Matthias Karst
Winfried Meissner
Winfried Häuser
ResearchOpen Access29 Sept 2025
Nature Medicine

Volume: 31, P: 4189-4196
Neuroprotective effects of hyperbaric oxygen therapy on vascular cognitive impairment in hypoperfused mice via miR-137-3p/TRAF3 pathway

Lu Yang
Hou-Ze Zhu
Zhe Li
ResearchOpen Access29 Nov 2025
Translational Psychiatry

Volume: 15, P: 1-15
An advanced approach for the electrical responses of discrete fractional-order biophysical neural network models and their dynamical responses

Yu-Ming Chu
Taher Alzahrani
Mohammad Alkhatib
ResearchOpen Access24 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
Observations at 610 Megacycles/Sec of the Radiation from Jupiter

D. BARBER
G. L. MOULE
Research08 Jun 1963
Nature

Volume: 198, P: 947-948
A systematic review and meta-analysis of Zika virus epidemiology

A systematic review including 574 studies extracts information about transmissibility, epidemiological delays and outbreaks for Zika virus disease at global scale.

Kelly McCain
Anna Vicco
Ilaria Dorigatti
ResearchOpen Access13 Feb 2026
Nature Health

P: 1-13
Estimation of Electron Affinities of Oxygen by Extrapolations of Ionization Potentials

D. F. C. MORRIS
H. N. SCHMEISING
Research15 Feb 1958
Nature

Volume: 181, P: 469-470
Mrc1 (MMR, CD206) controls the blood proteome in reducing inflammation, age-associated organ dysfunction and mortality in sepsis

With increasing river flow, sand dunes on the riverbed initially grow and eventually flatten out. However, flume experiments show that dune height distributions under high flow are bimodal, suggesting flickering between high and low dune heights.

Damien Restagno
Mayank Saraswat
Jamey D. Marth
ResearchOpen Access07 Jul 2025
Nature Communications

Volume: 16, P: 1-13
Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer’s disease-relevant brain circuits

This latest research reveals that changes in PSEN2 expression accelerate amyloid build-up, disrupt lysosomal function, and weaken synaptic connections. These findings spotlight PSEN2 as a powerful target for early Alzheimer’s disease intervention.

Anika Perdok
Zoë P. Van Acker
Wim Annaert
ResearchOpen Access29 Nov 2024
Nature Communications

Volume: 15, P: 1-20
Age differences in endocannabinoid tone are ameliorated after recent cannabis use

Alan W. J. Morris
Raeghan L. Mueller
Kent E. Hutchison
ResearchOpen Access24 Jan 2026
Scientific Reports

Volume: 16, P: 1-9
The Born-Fajans-Haber Correlation

D. F. C. MORRIS
E. L. SHORT
Research06 Dec 1969
Nature

Volume: 224, P: 950-952
Mapping the genetic landscape across 14 psychiatric disorders

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

Andrew D. Grotzinger
Josefin Werme
Jordan W. Smoller
ResearchOpen Access10 Dec 2025
Nature

Volume: 649, P: 406-415
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

Henriette van Praag
Gerd Kempermann
Fred H. Gage
Research01 Mar 1999
Nature Neuroscience

Volume: 2, P: 266-270
What's in a Virus Name?

A. J. GIBBS
B. D. HARRISON
P. WILDY
Research29 Jan 1966
Nature

Volume: 209, P: 450-454
Ultrasonic borehole televiewer investigation of oceanic crustal layer 2A, Costa Rica Rift

Mark D. Zoback
Roger N. Anderson
Research04 Feb 1982
Nature

Volume: 295, P: 375-379
Use of Ultra-violet-irradiated Sea Water in the Preparation of Culture Media

R. D. HAMILTON
A. F. CARLUCCI
Research30 Jul 1966
Nature

Volume: 211, P: 483-484
Synthesis of growth hormone by bacteria

P. H. Seeburg
J. Shine
H. M. Goodman
Research01 Dec 1978
Nature

Volume: 276, P: 795-798
D-aspartate exerts an opposing role upon age-dependent NMDAR-related synaptic plasticity and memory decay

Francesco Errico
Robert Nistico’
Alessandro Usiello
ResearchOpen Access15 May 2008
Nature Precedings

P: 1
Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent T_reg–microglia crosstalk

Nasal anti-CD3 therapy shows promise for treating traumatic brain injury by reducing neuroinflammation and aiding recovery in mice. It induces interleukin-10-producing regulatory T cells that enhance microglial phagocytic activity and reduce chronic inflammation, potentially aiding brain repair.

Saef Izzy
Taha Yahya
Howard L. Weiner
ResearchOpen Access27 Feb 2025
Nature Neuroscience

Volume: 28, P: 499-516
Multi-generational koala pedigree analysis reveals rapid changes in heritable provirus load associated with life history traits

Koala retroviruses are models of transposable element colonization of germlines. By mapping their integration sites in koala pedigrees, this study provides genetic risk scoring for breeding decisions and documents rates of acquisition and loss of retroviral integrations across generations.

Guilherme B. Neumann
Rachael Tarlinton
Alex D. Greenwood
ResearchOpen Access09 Jan 2026
Nature Communications

Volume: 17, P: 1-13
The MEK–RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers

Haines et al. developed an MEK–RAF molecular glue called IK-595 that blocks MAPK pathway activation in RAS-mutant and BRAF-mutant cancer cells. IK-595 exhibited high tolerability and strong antitumor effects in preclinical models across cancer types.

Eric Haines
Michael Burke
Sabine K. Ruppel
Research02 Jan 2026
Nature Cancer

Volume: 7, P: 116-130
High-resolution VLA images of the Galactic Centre at 2-cm wavelength with large dynamic range

Jun-Hui Zhao
W. M. Goss
R. D. Ekers
Research07 Nov 1991
Nature

Volume: 354, P: 46-48
Remembering landmarks

Andrew T. D. Bennett
Research22 Jul 1993
Nature

Volume: 364, P: 293-294
The SK2-long isoform directs synaptic localization and function of SK2-containing channels

SK2-containing channels are expressed on dendritic spines of mouse CA1 pyramidal neurons and influence synaptic responses, plasticity and learning. Allen et al. find that the long isoform of SK2 directs synaptic SK2-containing channel expression, mediating synaptic and behavioral effects.

Duane Allen
Chris T Bond
John P Adelman
Research22 May 2011
Nature Neuroscience

Volume: 14, P: 744-749
Determination of the spin and parity of all-charm tetraquarks

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

A. Hayrapetyan
V. Makarenko
A. Snigirev
ResearchOpen Access03 Dec 2025
Nature

Volume: 648, P: 58-63
Natural variation in a homolog of Antirrhinum CENTRORADIALIS contributed to spring growth habit and environmental adaptation in cultivated barley

Robbie Waugh and colleagues report that the EARLINESS PER SE (EPS2) locus is associated with spring growth habit and environmental adaptation in barley. Resequencing the barley homolog of CENTRORADIALIS, located within the EPS2 locus, in 216 spring and 207 winter barley accessions identified haplotypes at HvCEN that correspond with winter or spring growth habit.

Jordi Comadran
Benjamin Kilian
Robbie Waugh
Research18 Nov 2012
Nature Genetics

Volume: 44, P: 1388-1392
Leucoanthocyanins from the Leaves of European Larch (Larix decidua, Mill)

H. G. C. KING
Research27 Aug 1966
Nature

Volume: 211, P: 944-945
A highly conserved neuronal microexon in DAAM1 controls actin dynamics, RHOA/ROCK signaling, and memory formation

Actin is crucial for nervous system function yet the role of microexons in its modulation is unclear. Here, the authors show that a microexon in DAAM1 has a role in actin dynamics, neuronal function and memory formation in mice.

Patryk Poliński
Marta Miret Cuesta
Manuel Irimia
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-21
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Identification of 1,25-Dihydroxycholecalciferol, a New Kidney Hormone controlling Calcium Metabolism

D. E. M. LAWSON
D. R. FRASER
DUDLEY H. WILLIAMS
Research26 Mar 1971
Nature

Volume: 230, P: 228-230

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