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Showing 1–50 of 326 results

Advanced filters: Author: D. O'Shea Clear advanced filters

Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases

Francesco Colucci
Edina Schweighoffer
James P. Di Santo
Research11 Feb 2002
Nature Immunology

Volume: 3, P: 288-294
A unique geochemical record at the Permian/Triassic boundary

William T. Holser
Hans-Peter Schönlaub
Rupert Schmöller
Research05 Jan 1989
Nature

Volume: 337, P: 39-44
The p21 cyclin–dependent kinase inhibitor suppresses tumorigenicity in vivo

Zhi-Yong Yang
Neil D. Perkins
Gary J. Nabel
Research01 Oct 1995
Nature Medicine

Volume: 1, P: 1052-1056
Large-scale high-density brain-wide neural recording in nonhuman primates

Neuropixels 1.0 NHP is a 45-mm, high-density silicon probe capable of recording large numbers of neurons with single-neuron resolution from most areas in a macaque’s brain.

Eric M. Trautmann
Janis K. Hesse
Timothy Harris
ResearchOpen Access23 Jun 2025
Nature Neuroscience

Volume: 28, P: 1562-1575
Action of formamidine pesticides on octopamine receptors

Peter D. Evans
Julian D. Gee
Research04 Sept 1980
Nature

Volume: 287, P: 60-62
Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns

François Michel
Andrew D. Ellington
Jack W. Szostak
Research01 Oct 1990
Nature

Volume: 347, P: 578-580
Remodeling of Il4-Il13-Il5 locus underlies selective gene expression

O’Shea and colleagues examine the three-dimensional chromatin architecture of the type 2 cytokine locus and how it differs between innate ILC2 cells and adaptive T_H2 lymphocytes.

Hiroyuki Nagashima
Justin Shayne
John J. O’Shea
Research20 Nov 2024
Nature Immunology

Volume: 25, P: 2220-2233
Ethylmalonic/Adipic Aciduria: Effects of Oral Medium-Chain Triglycerides, Carnitine, and Glycine on Urinary Excretion of Organic Acids, Acylcarnitines, and Acylglycines

Piero Rinaldo
Roy D Welch
Arthur B Zinn
Research01 Sept 1991
Pediatric Research

Volume: 30, P: 216-221
Organic synthesis in the atmosphere of Titan

S. Gupta
E. Ochiai
C. Ponnamperuma
Research29 Oct 1981
Nature

Volume: 293, P: 725-727
Are buried salt bridges important for protein stability and conformational specificity?

Carey D. Waldburger
Joel F. Schildbach
Robert T. Sauer
Research01 Feb 1995
Nature Structural Biology

Volume: 2, P: 122-128
Chemical codes for the control of behaviour in arthropods

Gerd Bicker
Randolf Menzel
Reviews05 Jan 1989
Nature

Volume: 337, P: 33-39
The genetic architecture of protein interaction affinity and specificity

Here, the authors build a map of how mutations alter the binding of JUN to all 54 human bZIP proteins, revealing how affinity and specificity can be tuned and how determinants of specificity distribute in a protein interaction interface.

Alexandra M. Bendel
Andre J. Faure
Guillaume Diss
ResearchOpen Access14 Oct 2024
Nature Communications

Volume: 15, P: 1-20
Identification of small molecule dimethyoxyphenyl piperazine inhibitors of alpha-synuclein fibril growth

Helen Hwang
Dhruva D. Dhavale
Paul T. Kotzbauer
ResearchOpen Access26 Sept 2025
Scientific Reports

Volume: 15, P: 1-14
The patient-specific mouse model with Foxg1 frameshift mutation provides insights into the pathophysiology of FOXG1 syndrome

FOXG1 syndrome phenotypes depends largely on mutation type. Here authors generate a mouse model carrying the patient-specific Q84 mutation and report the N-terminal fragment produced, modifies the intracellular localization of FOXG1, and promotes radial glia identity while suppressing migration.

Shin Jeon
Jaein Park
Soo-Kyung Lee
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-19
Author Correction: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8⁺ T cells

Chen Yao
Guohua Lou
Tuoqi Wu
Amendments and Corrections03 Mar 2021
Nature Immunology

Volume: 22, P: 530
An engineered IL-2 partial agonist promotes CD8⁺ T cell stemness

H9T, an engineered IL-2 partial agonist, promotes the expansion of T cells while maintaining a stem-cell-like state, leading to improved efficacy of adoptive cell therapy in mouse models of melanoma and acute lymphoblastic leukaemia.

Fei Mo
Zhiya Yu
Warren J. Leonard
Research15 Sept 2021
Nature

Volume: 597, P: 544-548
An octopaminergic neurone modulates neuromuscular transmission in the locust

PETER D. EVANS
MICHAEL O'SHEA
Research17 Nov 1977
Nature

Volume: 270, P: 257-259
HIV clearance in an infant?

M. O. McClure
P. D. Bieniasz
E. C. Holmes
Research22 Jun 1995
Nature

Volume: 375, P: 637
Observation of acceleration and deceleration in gigaelectron-volt-per-metre gradient dielectric wakefield accelerators

Wakefield accelerators are a cheaper and compact alternative to conventional particle accelerators for high-energy physics and coherent x-ray sources. Here, the authors demonstrate a field gradient in excess of a gigaelectron-volt-per-metre using a terahertz-frequency wakefield supported by a dielectric lined-waveguide.

B. D. O’Shea
G. Andonian
J. B. Rosenzweig
ResearchOpen Access14 Sept 2016
Nature Communications

Volume: 7, P: 1-7
From primordial clocks to circadian oscillators

X-ray, cryo-EM and kinetic studies of the circadian oscillator KaiBC from the photosynthetic bacterium Rhodobacter sphaeroides shed light on the evolution of self-regulating oscillators.

Warintra Pitsawong
Ricardo A. P. Pádua
Dorothee Kern
ResearchOpen Access22 Mar 2023
Nature

Volume: 616, P: 183-189
Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

The accumulation of alpha-synuclein fibrils within neurons is the defining feature of Lewy body dementia (LBD). Here the authors report a method to produce large quantities of alpha-synuclein fibrils that reproduce the complex structure of the fibrils that accumulate in LBD brain tissue.

Dhruva D. Dhavale
Alexander M. Barclay
Paul T. Kotzbauer
ResearchOpen Access29 Mar 2024
Nature Communications

Volume: 15, P: 1-18
Making the Most of Life

W. D. H.
Books & Arts12 Aug 1915
Nature

Volume: 95, P: 643
Discovery of a structural class of antibiotics with explainable deep learning

An explainable deep learning model using a chemical substructure-based approach for the exploration of chemical compound libraries identified structural classes of compounds with antibiotic activity and low toxicity.

Felix Wong
Erica J. Zheng
James J. Collins
Research20 Dec 2023
Nature

Volume: 626, P: 177-185
Leucine-zipper motif update

MARTYN K. WHITE
MICHAEL J. WEBER
Research13 Jul 1989
Nature

Volume: 340, P: 103-104
How many NMDA receptors?

BERTRAND LAMBOLEZ
PASCALE CURUTCHET
LIA PRADO DE CARVALHO
Research06 Sept 1990
Nature

Volume: 347, P: 26
Mortality before and after HIV infection in the complete UK population of haemophiliacs

Sarah C. Darby
David W. Ewart
Charles R. Rizza
Research07 Sept 1995
Nature

Volume: 377, P: 79-82
Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation

D. C. Kaluarachchi
V. Y. Chock
G. Natarajan
ResearchOpen Access23 Sept 2025
Journal of Perinatology

P: 1-7
Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster

Duncan Byers
Ronald L. Davis
John A. Kiger Jr
Research01 Jan 1981
Nature

Volume: 289, P: 79-81
A role for glucagon-like peptide-1 in the central regulation of feeding

M. D. Turton
D. O'Shea
S. R Bloom
Research04 Jan 1996
Nature

Volume: 379, P: 69-72
Two-colour pump–probe experiments with a twin-pulse-seed extreme ultraviolet free-electron laser

Free-electron lasers are a powerful new tool for studying properties and transient states of matter. Here, the authors use a novel seed scheme for generation of two XUV laser pulses of controlled wavelength and time separation that enables access to ultrafast phenomena with elemental sensitivity.

E. Allaria
F. Bencivenga
M. Zangrando
ResearchOpen Access18 Sept 2013
Nature Communications

Volume: 4, P: 1-7
Pulsatile inputs achieve tunable attenuation of gene expression variability and graded multi-gene regulation

Natural transcription factors are often regulated in a pulsatile fashion unlike many synthetic systems. Here the authors show that dynamic pulsatile signals reduce cell-to-cell gene expression variability in an optogenetic construct.

Dirk Benzinger
Mustafa Khammash
ResearchOpen Access30 Aug 2018
Nature Communications

Volume: 9, P: 1-10
Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain

Adrian R. Ferré-D'Amaré
George C. Prendergast
Stephen K. Burley
Research06 May 1993
Nature

Volume: 363, P: 38-45
Systems biology of energetic and atomic costs in the yeast transcriptome, proteome, and metabolome

Michael Barton
Balazs Papp
Casey Bergman
ResearchOpen Access29 Apr 2008
Nature Precedings

P: 1
DNA sequence and expression of the B95-8 Epstein—Barr virus genome

R. Baer
A. T. Bankier
B. G. Barrell
Research19 Jul 1984
Nature

Volume: 310, P: 207-211
Systems biology of energetic and atomic costs in the yeast transcriptome, proteome, and metabolome

Michael Barton
Balazs Papp
Casey Bergman
ResearchOpen Access22 Jul 2008
Nature Precedings

P: 1
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

Shih-Feng Tsai
David I. K. Martin
Stuart H. Orkin
Research08 Jun 1989
Nature

Volume: 339, P: 446-451
Stereochemistry in the disorder–order continuum of protein interactions

Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.

Estella A. Newcombe
Amanda D. Due
Birthe B. Kragelund
ResearchOpen Access27 Nov 2024
Nature

Volume: 636, P: 762-768
Design and synthesis of multi-haem proteins

Dan E. Robertson
Ramy S. Farid
P. Leslie Dutton
Research31 Mar 1994
Nature

Volume: 368, P: 425-432
Habenula contributions to negative self-cognitions

Self-related cognitions are central to identity and wellbeing. Using 7-Tesla MRI, Kung et al map a dynamic network centred on the habenula demonstrating its role in encoding self-directed thinking and adaptive responses to negative self-cognitions.

Po-Han Kung
Matthew D. Greaves
Trevor Steward
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-15
The Body in Health

W. D. H.
Books & Arts03 Jun 1915
Nature

Volume: 95, P: 370
Stress-induced phase separation in plastics drives the release of amorphous polymer micropollutants into water

Residual stresses are pervasive in most modern plastics. Here, the authors show that they promote the migration of low-molecular-weight amorphous polymer and additives from bulk plastics and release micropollutants into water.

Dunzhu Li
Peijing Li
John J. Boland
ResearchOpen Access23 Apr 2025
Nature Communications

Volume: 16, P: 1-12
Analysis of the variations in IL-28RA gene and their association with allergic rhinitis

Soo-Cheon Chae
Young-Ran Park
Hun-Taeg Chung
ResearchOpen Access01 Jun 2006
Experimental & Molecular Medicine

Volume: 38, P: 302-309
Microencapsulation of human cells: Its effects on growth of normal and tumour cells in vitro

SM Shimi
D Hopwood
A Cuschieri
Research01 May 1991
British Journal of Cancer

Volume: 63, P: 675-680
A new subunit of the human T-cell antigen receptor complex

Allan M. Weissman
Lawrence E. Samelson
Richard D. Klausner
Research04 Dec 1986
Nature

Volume: 324, P: 480-482
Cortical preparatory activity indexes learned motor memories

In rhesus monkeys, learning of a motor task is accompanied by uniform changes in preparatory activity in motor cortex that are orthogonal to the force-predictive neural state subspace.

Xulu Sun
Daniel J. O’Shea
Krishna V. Shenoy
Research26 Jan 2022
Nature

Volume: 602, P: 274-279
Dissociation of phosphoinositide hydrolysis and Ca²⁺ fluxes from the biological responses of a T-cell hybridoma

Jeffrey J. Sussman
Mladen Mercép
Jonathan D. Ashwell
Research18 Aug 1988
Nature

Volume: 334, P: 625-628
Neuronal correlates of sleep, wakefulness and arousal in a diurnal insect

Walter Kaiser
Jana Steiner-Kaiser
Research24 Feb 1983
Nature

Volume: 301, P: 707-709
Targets of the cyclin-dependent kinase Cdk1

Jeffrey A. Ubersax
Erika L. Woodbury
David O. Morgan
Research23 Oct 2003
Nature

Volume: 425, P: 859-864
Observation of quantum entanglement with top quarks at the ATLAS detector

Entanglement was observed in top–antitop quark events by the ATLAS experiment produced at the Large Hadron Collider at CERN using a proton–proton collision dataset with a centre-of-mass energy of √s = 13 TeV and an integrated luminosity of 140 fb⁻¹.

G. Aad
B. Abbott
L. Zwalinski
ResearchOpen Access18 Sept 2024
Nature

Volume: 633, P: 542-547
The Enzymatic Basis for the Dehydrogenation of 3-Phenylpropionic Acid: In Vitro Reaction of 3- Phenylpropionyl-CoA with Various Acyl-CoA Dehydrogenases

Piero Rinaldo
John J O'Shea
Kay Tanaka
Research01 May 1990
Pediatric Research

Volume: 27, P: 501-507

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