Nature Search

Antitubercular Activity of Diphenyl Ethers and Related Compounds

VINCENT C. BARRY
L. O'ROURKE
D. TWOMEY
Research06 Dec 1947
Nature

Volume: 160, P: 800-801
Matrix directs trophoblast differentiation in a bioprinted organoid model of early placental development

The placenta plays vital roles in supporting fetal development. Here, Richards et al. develop a high-throughput bioprinted trophoblast organoid model to recapitulate the microenvironment of the early placenta, enabling investigation of placenta development and evaluation of therapeutics for placenta dysfunction disorders.

Claire Richards
Hao Chen
Lana McClements
ResearchOpen Access12 Sept 2025
Nature Communications

Volume: 16, P: 1-19
Anti-Tubercular Activity of Oxidation Products of Substituted o-Phenylene Diamines

VINCENT C. BARRY
J. G. BELTON
D. TWOMEY
Research16 Oct 1948
Nature

Volume: 162, P: 622-623
Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats

Christopher Dubay
Madeleine Vincent
G. Mark Lathrop
Research01 Apr 1993
Nature Genetics

Volume: 3, P: 354-357
Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer

Yew S. Ho
Lora Swenson
Zygmunt S. Derewenda
Research02 Jan 1997
Nature

Volume: 385, P: 89-93
Reducing the clustering challenge in the IoT using two disjoint convex hulls

Huxiong Li
Bahram Sadeghi Bigham
Yi Wan
ResearchOpen Access17 May 2025
Scientific Reports

Volume: 15, P: 1-10
Segmental Demyelination of Peripheral Nerves in Krabbe's Disease

B. D. LAKE
Research01 Jan 1968
Nature

Volume: 217, P: 171-172
Evidence that freshwater mussels attempt temporal partitioning of their host fishes

Stephanie L. Smodis
Todd J. Morris
Josef D. Ackerman
ResearchOpen Access02 Oct 2025
Scientific Reports

Volume: 15, P: 1-9
Arterial stiffness and vascular aging: mechanisms, prevention, and therapy

Maximilian Jonathan Herzog
Patrick Müller
Ruediger C. Braun-Dullaeus
ReviewsOpen Access01 Sept 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-33
Animal Joint Behaviour under Excessive Loading

E. L. RADIN
I. L. PAUL
D. POLLOCK
Research09 May 1970
Nature

Volume: 226, P: 554-555
Proximate Analysis of Marine Standing Crops

T. R. PARSONS
J. D. H. STRICKLAND
Research26 Dec 1959
Nature

Volume: 184, P: 2038-2039
Chromosome Number of Marsilea

P. N. MEHRA
D. S. LOYAL
Research22 Feb 1958
Nature

Volume: 181, P: 577
Selective collateral elimination in early postnatal development restricts cortical distribution of rat pyramidal tract neurones

Brent B. Stanfield
Dennis D. M. O'Leary
Carl Fricks
Research22 Jul 1982
Nature

Volume: 298, P: 371-373
Problems of Organic Growth

J. MAYER
Research09 Jul 1949
Nature

Volume: 164, P: 65
A core nucleosome surface crucial for transcriptional silencing

Jeong-Hyun Park
Michael S. Cosgrove
Jef D. Boeke
Research16 Sept 2002
Nature Genetics

Volume: 32, P: 273-279
Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies

In an analysis of long-term safety events in 783 patients treated with T cell therapy in 38 trials, 2.3% of patients developed second primary malignancies, and vector integration analyses revealed no pathological insertions.

Julie K. Jadlowsky
Elizabeth O. Hexner
Joseph A. Fraietta
Research20 Jan 2025
Nature Medicine

Volume: 31, P: 1134-1144
Protein tyrosine kinase PYK2 involved in Ca²⁺-induced regulation of ion channel and MAP kinase functions

S. Lev
H. Moreno
J. Schlessinger
Research31 Aug 1995
Nature

Volume: 376, P: 737-745
Analysis of short tandem repeat expansions and their methylation state with nanopore sequencing

Expansions of short tandem repeats linked to neuropsychiatric disorders are measured by single-molecule sequencing.

Pay Giesselmann
Björn Brändl
Franz-Josef Müller
Research18 Nov 2019
Nature Biotechnology

Volume: 37, P: 1478-1481
Effective treatment of malignant hypercalcaemia with a single intravenous infusion of clodronate

NP O'Rourke
EV McCloskey
JA Kanis
Research01 Mar 1993
British Journal of Cancer

Volume: 67, P: 560-563
Determinants of mean arterial pressure and pulse pressure in chronic haemodialysis patients

AB Abdelfatah
G Motte
JM Chalopin
Research30 Oct 2001
Journal of Human Hypertension

Volume: 15, P: 775-779
Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

Haematopoietic stem cells emerge from the haemogenic endothelium via an endothelial-to-haematopoietic transition. Here, the authors show using single cell functional and transcriptional analyses that haemogenic endothelial cells begin to lose their endothelial potential while still located within the haemogenic endothelium.

Gemma Swiers
Claudia Baumann
Marella F. T. R. de Bruijn
Research11 Dec 2013
Nature Communications

Volume: 4, P: 1-10
Defining the extracellular matrix for targeted immunotherapy in adult and pediatric brain cancer

Zoe I. Day
Samuel Roberts-Thomson
Misty R. Jenkins
ResearchOpen Access14 Jun 2025
npj Precision Oncology

Volume: 9, P: 1-14
Activation of sodium–proton exchange is a prerequisite for Ca²⁺ mobilization in human platelets

W. Siffert
J. W. N. Akkerman
Research29 Jan 1987
Nature

Volume: 325, P: 456-458
Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death

Qiao Yan
Jeffrey Elliott
William D. Snider
Research31 Dec 1992
Nature

Volume: 360, P: 753-755
A new approach to protein fold recognition

D. T. Jones
W. R. Taylort
J. M. Thornton
Research02 Jul 1992
Nature

Volume: 358, P: 86-89
NINJ1 mediates plasma membrane rupture during lytic cell death

The small transmembrane protein NINJ1 promotes plasma membrane rupture in lytic cell death associated with pyroptosis, necrosis and apoptosis.

Nobuhiko Kayagaki
Opher S. Kornfeld
Vishva M. Dixit
Research20 Jan 2021
Nature

Volume: 591, P: 131-136
Io’s tidal response precludes a shallow magma ocean

By measuring the tidal deformation of Io as it orbits Jupiter using Juno Doppler and historically available data, the hypothesis of a shallow global magma ocean in Io is shown to be false.

R. S. Park
R. A. Jacobson
S. J. Bolton
ResearchOpen Access12 Dec 2024
Nature

Volume: 638, P: 69-73
JNK/SAPK activity contributes to TRAIL-induced apoptosis

Ingrid Herr
Dagmar Wilhelm
Klaus-Michael Debatin
Research28 Jan 1999
Cell Death & Differentiation

Volume: 6, P: 130-135
C9orf72 in myeloid cells suppresses STING-induced inflammation

Studies of mice and humans suggest a role for loss of the C9orf72 protein in some neurodegenerative disorders: with reduced C9orf72 levels, there is more inflammation mediated by the STING protein in immune and brain cells.

Madelyn E. McCauley
Jacqueline Gire O’Rourke
Robert H. Baloh
Research19 Aug 2020
Nature

Volume: 585, P: 96-101
Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog

Motoaki Yasuda
Cleta D'Sa-Eipper
G Chinnadurai
Research12 Oct 1998
Oncogene

Volume: 17, P: 2525-2530
Dose-response study of ibandronate in the treatment of cancer-associated hypercalcaemia

SH Ralston
D Thiébaud
JJ Body
Research01 Jan 1997
British Journal of Cancer

Volume: 75, P: 295-300
Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

A monoclonal antibody that binds NINJ1 and inhibits NINJ1 oligomerization prevents plasma membrane rupture in dying cells, resulting in decreased inflammation of surrounding tissue in mice.

Nobuhiko Kayagaki
Irma B. Stowe
Vishva M. Dixit
ResearchOpen Access17 May 2023
Nature

Volume: 618, P: 1072-1077
Drivers and implications of alternative routes to fuels decarbonization in net-zero energy systems

Assumptions about the use of biomass and CO₂ sequestration drive key differences in how emissions from remaining fuels are mitigated in net-zero energy systems, with potentially significant tradeoffs that will need to be evaluated and managed.

Bryan K. Mignone
Leon Clarke
Aranya Venkatesh
ResearchOpen Access10 May 2024
Nature Communications

Volume: 15, P: 1-14
Polygenic control of Caenorhabditis elegans fat storage

Ho Yi Mak
Laura S Nelson
Gary Ruvkun
Research05 Feb 2006
Nature Genetics

Volume: 38, P: 363-368
Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma

The mesothelium supports homeostasis and regeneration, yet its development origins remain unclear. Here, the authors uncovered the earliest mesothelium progenitor cells in zebrafish, linking Hand2 gene function to mesothelium formation and its re-activation to mesothelioma tumors.

Karin D. Prummel
Helena L. Crowell
Christian Mosimann
ResearchOpen Access30 Mar 2022
Nature Communications

Volume: 13, P: 1-21
The Philae lander reveals low-strength primitive ice inside cometary boulders

When the Philae lander bounced on the surface of comet 67P/Churyumov–Gerasimenko, it exposed primitive icy-dust material within cometary boulders; the intrinsic strength and porosity of this material is reported.

Laurence O’Rourke
Philip Heinisch
Holger Sierks
Research28 Oct 2020
Nature

Volume: 586, P: 697-701
Opsonization of Salmonella enteriditis Lipopolysaccharide in Sickle Cell Disease

Ronald J Field
Gary D Overturf
Robert Strunk
Research01 Feb 1981
Pediatric Research

Volume: 15, P: 107-111
Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study

Results from the LAVENDER phase 3 study demonstrate that trofinetide, a synthetic analog of glycine–proline–glutamate, provides significant therapeutic benefits in the core symptoms of Rett syndrome

Jeffrey L. Neul
Alan K. Percy
James M. Youakim
ResearchOpen Access08 Jun 2023
Nature Medicine

Volume: 29, P: 1468-1475
Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis

N Droin
L Dubrez
E Solary
Research09 Jun 1998
Oncogene

Volume: 16, P: 2885-2894
Erratum: Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Ingrid E. Wertz
Saritha Kusam
Vishva M. Dixit
Amendments and Corrections15 Jun 2011
Nature

Volume: 475, P: 122
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Ingrid E. Wertz
Saritha Kusam
Vishva M. Dixit
Research02 Mar 2011
Nature

Volume: 471, P: 110-114
A new antibiotic selectively kills Gram-negative pathogens

Bacterial symbionts of animals may contain antibiotics that are particularly suitable for development into therapeutics; one such compound, darobactin, is active against important Gram-negative pathogens both in vitro and in animal models of infection.

Yu Imai
Kirsten J. Meyer
Kim Lewis
Research20 Nov 2019
Nature

Volume: 576, P: 459-464
Relationships between hydrophobicity, reactivity, accumulation and peripheral nerve toxicity of a series of platinum drugs

D Screnci
M J McKeage
B C Baguley
ResearchOpen Access20 Jan 2000
British Journal of Cancer

Volume: 82, P: 966-972
The art and design of genetic screens: RNA interference

RNAi, a common gene knockdown technique, has been widely used in a variety of genetic screens. As part of our 'art and design of genetic screens' series, the authors discuss RNAi assay design and analytical approaches for large-scale screening experiments in cells and whole-animal experiments.

Michael Boutros
Julie Ahringer
Reviews03 Jun 2008
Nature Reviews Genetics

Volume: 9, P: 554-566
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

BET-bromodomain inhibitors could be used to treat medulloblastoma tumors with Myc amplifications. Here, the authors show that both the response and resistance to BET inhibitors in mice is mediated by bHLH/homeobox transcription factors.

Pratiti Bandopadhayay
Federica Piccioni
Rameen Beroukhim
ResearchOpen Access03 Jun 2019
Nature Communications

Volume: 10, P: 1-16
Assembly of functionally integrated human forebrain spheroids

Human pluripotent stem cells were used to develop dorsal and ventral forebrain 3D spheroids, which can be assembled to study interneuron migration and to derive a functionally integrated forebrain system with cortical interneurons and glutamatergic neurons.

Fikri Birey
Jimena Andersen
Sergiu P. Paşca
Research26 Apr 2017
Nature

Volume: 545, P: 54-59
A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer

Cox and colleagues develop PXS-5505, a first-in-class selective pan-lysyl oxidase inhibitor and show that it reduces chemotherapy-induced desmoplasia and stiffness, thereby improving chemotherapy response and survival in pancreatic cancer models.

Jessica L. Chitty
Michelle Yam
Thomas R. Cox
ResearchOpen Access28 Aug 2023
Nature Cancer

Volume: 4, P: 1326-1344
Abnormal Heart Rate Characteristics Preceding Neonatal Sepsis and Sepsis-Like Illness

M Pamela Griffin
T Michael O'Shea
J Randall Moorman
Research01 Jun 2003
Pediatric Research

Volume: 53, P: 920-926
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

Thimo Kurz
Nurhan Özlü
Matthias Peter
Research30 Jun 2005
Nature

Volume: 435, P: 1257-1261
The radiogenomic and spatiogenomic landscapes of glioblastoma and their relationship to oncogenic drivers

Kazerooni et al. explore the associations between tumor imaging and spatial characteristics with cancer gene mutations and the inferred sequence of mutational events. Radiogenomics reflects glioblastoma's molecular heterogeneity and imaging biomarkers and spatial patterns can reveal key oncogenic drivers.

Anahita Fathi Kazerooni
Hamed Akbari
Christos Davatzikos
ResearchOpen Access01 Mar 2025
Communications Medicine

Volume: 5, P: 1-15

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