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Showing 1–2 of 2 results
Advanced filters: Author: D. Spencer Currle Clear advanced filters
  • Medulloblastomas are the most common malignant childhood brain tumours and are thought to arise from the cerebellum. There is substantial heterogeneity among medulloblastomas and some are thought to arise following aberrant Sonic Hedgehog pathway activation. It is now shown that a distinct subtype of medulloblastoma arises from the dorsal brainstem and is associated with altered WNT signalling. Distinct molecular and clinical profiles of the subtypes have implications for future treatment.

    • Paul Gibson
    • Yiai Tong
    • Richard J. Gilbertson
    Research
    Nature
    Volume: 468, P: 1095-1099
  • It is shown that the cell surface protein prominin 1 (also known as CD133) marks stem cells in the mouse intestine. Using lineage-tracing experiments, it is shown that intestinal tumours can originate in these cells when the Wnt signalling pathway is aberrantly activated.

    • Liqin Zhu
    • Paul Gibson
    • Richard J. Gilbertson
    Research
    Nature
    Volume: 457, P: 603-607