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Showing 1–8 of 8 results
Advanced filters: Author: D. Taraborrelli Clear advanced filters
  • Patients with MMR-proficient, microsatellite stable (MSS) colorectal cancer (CRC) are highly resistant to immune-checkpoint inhibitors. Here the authors report that tumor intrinsic expression of the autophagy gene ATG16L1 is associated with resistance to anti-tumor immunity in preclinical CRC models and that elevated ATG16L1 expression predicts poor immunotherapy response in Kras-mutant CRC patients.

    • Lucia Taraborrelli
    • Yasin Şenbabaoğlu
    • Aditya Murthy
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17
  • The hydroxyl radical is a key oxidant in the Earth’s atmosphere. The inclusion in an atmospheric chemistry model of a detailed mechanism of isoprene oxidation, involving the buffering of hydroxyl radical concentrations, improves agreement between model simulations of hydroxyl radical levels and observations.

    • D. Taraborrelli
    • M. G. Lawrence
    • J. Lelieveld
    Research
    Nature Geoscience
    Volume: 5, P: 190-193
  • TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients are refractory to current anti-TNF therapeutics. Here the authors show induction of several death ligands, in addition to TNF is sufficient to cause fatal dermatitis in a LUBAC deficient murine model of disease.

    • Lucia Taraborrelli
    • Nieves Peltzer
    • Henning Walczak
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12
  • Aircraft measurements of atmospheric trace gases performed over the pristine Amazon forest find unexpectedly high hydroxyl radical concentrations. On the basis of a model study and the results of laboratory experiments, it is proposed that natural volatile organic compounds oxidation, notably of isoprene, recycles hydroxyl radical efficiently through reactions of organic peroxy radicals, which may be able to explain the high hydroxyl radical levels observed.

    • J. Lelieveld
    • T. M. Butler
    • J. Williams
    Research
    Nature
    Volume: 452, P: 737-740