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Showing 51–100 of 160 results

Advanced filters: Author: DAVID L MACINTOSH Clear advanced filters

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation

The molecular mechanisms underlying vascular inflammation are unclear. Here the authors show that pro-inflammatory stimuli lead to endothelial inflammation by increasing adenosine kinase expression, and that its knockdown in endothelial cells inhibits atherosclerosis and cerebral ischemic injury in mice.

Yiming Xu
Yong Wang
Yuqing Huo
ResearchOpen Access16 Oct 2017
Nature Communications

Volume: 8, P: 1-16
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes

Nicole Frahm
Photini Kiepiela
Christian Brander
Research20 Dec 2005
Nature Immunology

Volume: 7, P: 173-178
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

Holt et al. describe an anti-HIV strategy in which human hematopoietic stem/progenitor cells are modified with zinc-finger nucleases to knock out the viral co-receptor CCR5. Transplantation of these cells into mice confers resistance to HIV, as shown by higher human T-cell counts and lower viral loads compared with animals that received unmodified cells.

Nathalia Holt
Jianbin Wang
Paula M Cannon
Research02 Jul 2010
Nature Biotechnology

Volume: 28, P: 839-847
Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia

Cornelius F. Boerkoel
Hiroshi Takashima
David W. Stockton
Research22 Jan 2002
Nature Genetics

Volume: 30, P: 215-220
The use of tolerance for transplantation across xenogeneic barriers

Julia L. Greenstein
David H. Sachs
Reviews01 Mar 1997
Nature Biotechnology

Volume: 15, P: 235-238
Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel

Max L. Schiff
David P. Siderovski
María Diversé-Pierluissi
Research07 Dec 2000
Nature

Volume: 408, P: 723-727
Channel opening locks agonist onto the GABA_C receptor

Yongchang Chang
David S. Weiss
Research01 Mar 1999
Nature Neuroscience

Volume: 2, P: 219-225
Effect of extrinsic mortality on the evolution of senescence in guppies

David N. Reznick
Michael J. Bryant
Dionna E. Ghalambor
Research28 Oct 2004
Nature

Volume: 431, P: 1095-1099
Three-dimensional ultrasound imaging of the eye

Dónal B Downey
David A Nicolle
Aaron Fenster
Research01 Jan 1996
Eye

Volume: 10, P: 75-81
The complete genome of the hyperthermophilic bacterium Aquifex aeolicus

Gerard Deckert
Patrick V. Warren
Ronald V. Swanson
Research26 Mar 1998
Nature

Volume: 392, P: 353-358
Image analysis-based tumor infiltrating lymphocytes measurement predicts breast cancer pathologic complete response in SWOG S0800 neoadjuvant chemotherapy trial

Kristina A. Fanucci
Yalai Bai
Kim R. M. Blenman
ResearchOpen Access13 May 2023
npj Breast Cancer

Volume: 9, P: 1-7
A Bacillus thuringiensis δ-endotoxin induces programmed cell death in mosquito larvae

David Smouse
James Nishiura
Research01 Oct 1997
Cell Death & Differentiation

Volume: 4, P: 560-569
Unrelated helpers in a social insect

David C. Queller
Francesca Zacchi
Joan E. Strassmann
Research15 Jun 2000
Nature

Volume: 405, P: 784-787
Visualization of image data from cells to organisms

Thomas Walter
David W Shattuck
Jean-Karim Hériché
Reviews01 Mar 2010
Nature Methods

Volume: 7, P: S26-S41
The benefits of whole-house in-duct air cleaning in reducing exposures to fine particulate matter of outdoor origin: A modeling analysis

David L MacIntosh
Taeko Minegishi
Theodore A Myatt
Research25 Mar 2009
Journal of Exposure Science & Environmental Epidemiology

Volume: 20, P: 213-224
Human/mouse radiation chimera generated from PBMC of B chronic lymphocytic leukemia patients with autoimmune hemolytic anemia produce anti-human red cell antibodies

H Marcus
A Shimoni
A Berrebi
Research01 May 1997
Leukemia

Volume: 11, P: 687-693
The complex evolution of the metazoan HSP70 gene family

Er-meng Yu
Tatsuki Yoshinaga
Gen Kaneko
ResearchOpen Access07 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
Very low embryonic crude oil exposures cause lasting cardiac defects in salmon and herring

John P. Incardona
Mark G. Carls
Nathaniel L. Scholz
ResearchOpen Access08 Sept 2015
Scientific Reports

Volume: 5, P: 1-13
Reproducible molecular networking of untargeted mass spectrometry data using GNPS

Global Natural Product Social Molecular Networking (GNPS) is an online tandem mass spectrometry (MS²) data curation and analysis infrastructure. This protocol describes how to use GNPS to explore uploaded metabolomics data.

Allegra T. Aron
Emily C. Gentry
Pieter C. Dorrestein
Protocols13 May 2020
Nature Protocols

Volume: 15, P: 1954-1991
The present and future role of microfluidics in biomedical research

Recent progress in the various lab-on-a-chip microtechnologies is reviewed and the clinical and research areas in which they have made the greatest impact are discussed.

Eric K. Sackmann
Anna L. Fulton
David J. Beebe
Reviews12 Mar 2014
Nature

Volume: 507, P: 181-189
Computational protein–ligand docking and virtual drug screening with the AutoDock suite

This protocol describes the use of the AutoDock suite for computational docking in the study of protein–ligand interactions. A number of methods are described ranging from basic docking of drug molecules to virtual screening using a large ligand library of chemical compounds.

Stefano Forli
Ruth Huey
Arthur J Olson
Protocols14 Apr 2016
Nature Protocols

Volume: 11, P: 905-919
In Utero Ventilation Augments the Left Ventricular Response to Isoproterenol and Volume Loading in Fetal Sheep

David F Teitel
Michiel Dalinghaus
Abraham M Rudolph
Research01 May 1991
Pediatric Research

Volume: 29, P: 466-472
Hydroxyurea blunts mitochondrial energy metabolism and osteoblast and osteoclast differentiation exacerbating trabecular bone loss in sickle cell mice

Ashish Kumar Tripathi
Sadaf Dabeer
M. Neale Weitzmann
ResearchOpen Access18 Dec 2024
Cell Death & Disease

Volume: 15, P: 1-14
Up-Regulation of IL-18 and IL-12 in the Ileum of Neonatal Rats with Necrotizing Enterocolitis

Melissa D Halpern
Hana Holubec
Bohuslav Dvorak
Research01 Jun 2002
Pediatric Research

Volume: 51, P: 733-739
Rational design of anti-GITR-based combination immunotherapy

GITR agonism can be exploited in combination with checkpoint blockade to overcome immune refractoriness in solid tumors.

Roberta Zappasodi
Cynthia Sirard
Taha Merghoub
Research29 Apr 2019
Nature Medicine

Volume: 25, P: 759-766
Rethinking forest carbon assessments to account for policy institutions

The relative climate benefits of sustainable forest use versus conservation are much debated. Consequential life-cycle assessment is typically employed to answer this question but results are sensitive to contextual factors including policy institutions.

Andrew Macintosh
Heather Keith
David Lindenmayer
Research29 Jun 2015
Nature Climate Change

Volume: 5, P: 946-949
The End-Systolic Pressure-Volume Relationship in the Newborn Lamb: Effects of Loading and Inotropic Interventions

David F Teitel
R Klautz
J Baan
Research01 May 1991
Pediatric Research

Volume: 29, P: 473-482
Alteration of a brain network with stable and strong functional connections in subjects with schizophrenia

Liu Yuan
Xiaoqian Ma
Xiaogang Chen
ResearchOpen Access04 Nov 2022
Schizophrenia

Volume: 8, P: 1-10
Amplification of a Chimeric Bacillus Gene in Chloroplasts Leads to an Extraordinary Level of an Insecticidal Protein in Tobacco

Kevin E. McBride
Zora Svab
Pal Maliga
Research01 Apr 1995
Bio/Technology

Volume: 13, P: 362-365
STAT3 signaling controls satellite cell expansion and skeletal muscle repair

In two new reports, STAT3 signaling is shown to be increased in adult muscle satellite cells, and its inhibition improves muscle regeneration.

Matthew Timothy Tierney
Tufan Aydogdu
Alessandra Sacco
Research07 Sept 2014
Nature Medicine

Volume: 20, P: 1182-1186
jModelTest 2: more models, new heuristics and parallel computing

Diego Darriba
Guillermo L Taboada
David Posada
Correspondence30 Jul 2012
Nature Methods

Volume: 9, P: 772
Effects of Substance P in the Amygdala, Ventromedial Hypothalamus, and Periaqueductal Gray on Fear-Potentiated Startle

Zuowei Zhao
Yong Yang
Michael Davis
Research16 Apr 2008
Neuropsychopharmacology

Volume: 34, P: 331-340
Characterization of the Coleopteran–Specific Protein Gene of Bacillus thuringiensis Var. tenebrionis

Sylvia A. McPherson
Frederick J. Perlak
David A. Fischhoff
Research01 Jan 1988
Bio/Technology

Volume: 6, P: 61-66
Using transmission electron microscopy and 3View to determine collagen fibril size and three-dimensional organization

Tobias Starborg
Nicholas S Kalson
Karl E Kadler
Protocols27 Jun 2013
Nature Protocols

Volume: 8, P: 1433-1448
Assessing exposure to granite countertops—part 2: Radon

Joseph G Allen
Taeko Minegishi
David L Macintosh
Research26 Aug 2009
Journal of Exposure Science & Environmental Epidemiology

Volume: 20, P: 263-272
Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization

Until now, no tools existed to selectively manipulate the small number of sparsely distributed neurons activated during a drug-related learned behavior. Here the authors describe a new method for selectively inactivating only those neurons activated by cocaine in an environment repeatedly paired with drug injections.

Eisuke Koya
Sam A Golden
Bruce T Hope
Research20 Jul 2009
Nature Neuroscience

Volume: 12, P: 1069-1073
Andy’s Algorithms: new automated digital image analysis pipelines for FIJI

Andrew M. K. Law
Julia X. M. Yin
Samantha R. Oakes
ResearchOpen Access16 Nov 2017
Scientific Reports

Volume: 7, P: 1-11
Congenital Chylothorax in Neonatal Thyrotoxicosis

Hassan Ibrahim
Alexander Asamoah
Arun K Pramanik
Research01 Sept 1999
Journal of Perinatology

Volume: 19, P: 68-71
Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression

James M. Brimson
Kiran K. Akula
Stephen T. Safrany
ResearchOpen Access08 Jun 2020
Scientific Reports

Volume: 10, P: 1-13
Metabotropic glutamate receptor-1 regulates inflammation in triple negative breast cancer

Rachel E. Sexton
Ali H. Hachem
Cecilia L. Speyer
ResearchOpen Access30 Oct 2018
Scientific Reports

Volume: 8, P: 1-11
Quinolinate in Brain and Cerebrospinal Fluid in Rat Models of Congenital Hyperammonemia

Michael B Robinson
Melvyn P Heyes
Mark L Batshaw
Research01 Oct 1992
Pediatric Research

Volume: 32, P: 483-488
Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data

This work compares several ML and calibration algorithms for classifying tumor DNA methylation profiles. The resulting protocol provides workflows for selecting, training and calibrating ML algorithms to generate well-calibrated multiclass probability estimates.

Máté E. Maros
David Capper
Martin Sill
Protocols13 Jan 2020
Nature Protocols

Volume: 15, P: 479-512
Corresponding morphological and molecular indicators of crude oil toxicity to the developing hearts of mahi mahi

Richard C. Edmunds
J. A. Gill
John P. Incardona
ResearchOpen Access10 Dec 2015
Scientific Reports

Volume: 5, P: 1-18
Δ⁹-Tetrahydrocannabinol Increases Prefrontal Cortical Catecholaminergic Utilization and Impairs Spatial Working Memory in the Rat: Blockade of Dopaminergic Effects with HA966

J David Jentsch
Ericka Andrusiak
Robert H Roth
Research01 Jun 1997
Neuropsychopharmacology

Volume: 16, P: 426-432
The Conductance Volume Catheter Technique for Measurement of Left Ventricular Volume in Young Piglets

Steven C Cassidy
David F Teitel
Research01 Jan 1992
Pediatric Research

Volume: 31, P: 85-90
KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden

Tenielle Porter
Samantha C. Burnham
Simon M. Laws
ResearchOpen Access01 Feb 2018
Scientific Reports

Volume: 8, P: 1-9
Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite’s food vacuole and alter drug sensitivities

Serena Pulcini
Henry M. Staines
Sanjeev Krishna
ResearchOpen Access30 Sept 2015
Scientific Reports

Volume: 5, P: 1-16
Low dietary inclusion of nutraceuticals from microalgae improves feed efficiency and modifies intermediary metabolisms in gilthead sea bream (Sparus aurata)

Erick Perera
David Sánchez-Ruiz
Juan Antonio Martos-Sitcha
ResearchOpen Access29 Oct 2020
Scientific Reports

Volume: 10, P: 1-14
DOC-2/hDab2, a candidate tumor suppressor gene involved in the development of gestational trophoblastic diseases

Vilmos Fulop
Cristiano V Colitti
Samuel C Mok
Research03 Aug 1998
Oncogene

Volume: 17, P: 419-424
Mitochondrial genome size variation in New World and Old World populations of Drosophila melanogaster

J P Townsend
D M Rand
Research12 May 2004
Heredity

Volume: 93, P: 98-103

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