Thalamocortical axonal inputs to the neocortex terminate in the cortical layer 4, whereas corticobulbar and corticospinal output from the cortex mostly originate from layer 5B pyramidal neurons. This study utilizes a novel in vivo gene expression system in postmitotic neurons and demonstrates the reprogramming of layer 4 input-receiver neurons in postnatal mice into layer 5B–like cortical output neurons using the expression of the transcription factor Fezf2.
- Andres De la Rossa
- Camilla Bellone
- Denis Jabaudon
