Pathogenic autoantibodies trigger thromboses in antiphospholipid syndrome (APS), through several mechanisms that favor blood clotting and act in concert with inflammatory events. APS-associated fetal loss, however, is not fully explained by thrombogenic mechanisms, and other, direct actions of the autoantibodies are proposed. This Review summarizes the autoantibody-mediated pathways in APS, with a focus on the causes of pregnancy complications.
- Pier Luigi Meroni
- M. Orietta Borghi
- Francesco Tedesco
