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Showing 1–2 of 2 results
Advanced filters: Author: Daan M. K. van Soest Clear advanced filters

  • Oxidative DNA damage is linked to cancer and aging, but its genomic effects remain hard to map. Here, authors develop a nanopore-based method using synthetic DNA and deep learning to detect 8- oxo-dG, revealing its distribution and interplay with DNA methylation.

    • Marc Pagès-Gallego
    • Daan M. K. van Soest
    • Jeroen de Ridder
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Nuclear DNA damage downstream of mitochondrial ROS is often cited to contribute to cancer initiation and aging. However, here the authors show that although H2O2 induces DNA mutations when produced near DNA, it does not when released by mitochondria.

    • Daan M. K. van Soest
    • Paulien E. Polderman
    • Tobias B. Dansen
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16