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Showing 1–3 of 3 results

Advanced filters: Author: Daehyeon Seong Clear advanced filters

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

Receptor-interacting protein kinase 3 (RIPK3) is a key regulator of necroptosis. Seo et al. show that the E3 ligase CHIP mediates ubiquitylation and lysosomal degradation of RIPK3, thus regulating both necrosome formation and necroptosis.

Jinho Seo
Eun-Woo Lee
Jaewhan Song
Research22 Feb 2016
Nature Cell Biology

Volume: 18, P: 291-302
Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex

Jinho Seo
Daehyeon Seong
Jaewhan Song
ResearchOpen Access26 May 2020
Cell Death & Differentiation

Volume: 27, P: 3065-3081
K6 linked polyubiquitylation of FADD by CHIP prevents death inducing signaling complex formation suppressing cell death

Jinho Seo
Eun-Woo Lee
Jaewhan Song
Research23 May 2018
Oncogene

Volume: 37, P: 4994-5006