The MSL complex is conserved and in Drosophila melanogaster is involved in spreading of gene activation on the male X chromosome. Structural and functional analyses of the MSL3 chromodomain now indicate that DNA binding promotes methylated histone tail binding, suggesting coordinated binding that is here proposed to promote cross-nucleosome interaction in an array.
- Daesung Kim
- Bartlomiej J Blus
- Sepideh Khorasanizadeh
